 |
Eli Lilly and Company
LLY
|
$ 1 082.94
|
975 B
|
$ 2.37 B
|
78.3
|
19.0
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 208.0
|
501 B
|
$ 9.42 B
|
20.5
|
5.4
|
$ 10.1
|
 |
 |
AbbVie
ABBV
|
$ 230.75
|
408 B
|
$ 15.1 B
|
103.5
|
6.9
|
$ 2.2
|
 |
 |
Merck & Co.
MRK
|
$ 106.87
|
271 B
|
$ 2.86 B
|
14.5
|
4.1
|
$ 7.3
|
 |
 |
Novartis AG
NVS
|
$ 138.94
|
227 B
|
$ 10.7 B
|
23.9
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 330.28
|
177 B
|
$ 12.4 B
|
25.1
|
6.7
|
$ 13.2
|
 |
 |
Gilead Sciences
GILD
|
$ 124.55
|
155 B
|
$ 9.3 B
|
20.5
|
5.4
|
$ 6.1
|
 |
 |
Pfizer
PFE
|
$ 25.08
|
142 B
|
$ 6.66 B
|
10.3
|
2.3
|
$ 2.4
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 459.21
|
118 B
|
$ 4.29 B
|
31.2
|
10.3
|
$ 14.8
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 54.23
|
110 B
|
$ 11 B
|
16.6
|
2.3
|
$ 3.3
|
 |
 |
AstraZeneca PLC
AZN
|
$ 92.68
|
96.9 B
|
$ 3.67 B
|
68.2
|
3.8
|
$ 1.4
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 780.06
|
84.2 B
|
$ 4.1 B
|
16.8
|
6.0
|
$ 46.5
|
 |
 |
Zoetis
ZTS
|
$ 126.33
|
57.4 B
|
$ 487 M
|
20.5
|
6.0
|
$ 6.2
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 398.73
|
50.9 B
|
$ -361 M
|
-204.9
|
20.2
|
$ -2.0
|
 |
 |
Axon Enterprise
AXON
|
$ 583.1
|
44.2 B
|
$ 89.9 M
|
151.1
|
23.9
|
$ 3.9
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 31.53
|
35.7 B
|
$ 2.81 B
|
74.0
|
2.1
|
$ 0.4
|
 |
 |
Insmed Incorporated
INSM
|
$ 176.0
|
28.9 B
|
$ -1.06 B
|
-28.1
|
76.0
|
$ -6.3
|
 |
 |
Biogen
BIIB
|
$ 177.51
|
25.8 B
|
$ 2.03 B
|
13.9
|
2.6
|
$ 12.7
|
 |
 |
argenx SE
ARGX
|
$ 838.95
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
United Therapeutics Corporation
UTHR
|
$ 501.7
|
22.7 B
|
$ 1.42 B
|
18.6
|
7.5
|
$ 27.2
|
 |
 |
Incyte Corporation
INCY
|
$ 98.93
|
20.5 B
|
$ 573 M
|
70.4
|
4.6
|
$ 1.4
|
 |
 |
Legend Biotech Corporation
LEGN
|
$ 21.91
|
18.7 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Zai Lab Limited
ZLAB
|
$ 17.79
|
17.6 B
|
$ -218 M
|
-122.7
|
41.9
|
$ -0.2
|
 |
 |
Royalty Pharma plc
RPRX
|
$ 39.13
|
17.5 B
|
$ 1.1 B
|
15.6
|
7.6
|
$ 2.5
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 143.62
|
14.4 B
|
$ 124 M
|
46.9
|
5.9
|
$ 3.1
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 75.22
|
14 B
|
$ -603 M
|
-24.6
|
60.8
|
$ -3.1
|
 |
 |
Revolution Medicines
RVMD
|
$ 80.35
|
13.5 B
|
$ -989 M
|
-16.2
|
580.9
|
$ -5.0
|
 |
 |
Exelixis
EXEL
|
$ 45.35
|
13.2 B
|
$ 363 M
|
19.4
|
5.9
|
$ 2.4
|
 |
 |
Summit Therapeutics
SMMT
|
$ 17.81
|
12.8 B
|
$ -609 M
|
-14.6
|
6461.2
|
$ -1.2
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 589.59
|
12.5 B
|
$ -389 M
|
-39.3
|
18.2
|
$ -15.2
|
 |
 |
Mesoblast Limited
MESO
|
$ 18.99
|
12.3 B
|
∙ |
-2.6
|
1277.8
|
$ -7.6
|
 |
 |
Moderna
MRNA
|
$ 31.13
|
12 B
|
$ -2.09 B
|
-6.1
|
3.8
|
$ -5.1
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 79.67
|
11.9 B
|
$ -451 M
|
-51.7
|
12.7
|
$ -1.6
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 60.08
|
11.4 B
|
$ 790 M
|
17.9
|
3.8
|
$ 3.3
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 13.26
|
11.3 B
|
$ -59 M
|
-274.0
|
112.1
|
$ -0.0
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 171.06
|
10.6 B
|
$ 73.8 M
|
-30.4
|
2.6
|
$ -5.6
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 59.05
|
9.3 B
|
$ 292 M
|
72.1
|
7.8
|
$ 0.8
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 69.22
|
9.26 B
|
$ -610 M
|
-13.9
|
189.4
|
$ -5.0
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 69.05
|
8.76 B
|
$ 736 M
|
14.1
|
7.1
|
$ 4.9
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 80.0
|
8.26 B
|
$ 80.9 M
|
71.4
|
11.5
|
$ 1.2
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 42.82
|
8.14 B
|
$ -373 M
|
-0.1
|
85.6
|
$ -791.5
|
 |
 |
Pulmatrix
PULM
|
$ 2.22
|
8.11 B
|
$ -13.2 M
|
-2.7
|
886.6
|
$ -0.9
|
 |
 |
Avidity Biosciences
RNA
|
$ 72.15
|
8.05 B
|
$ -586 M
|
-17.9
|
397.9
|
$ -4.0
|
 |
 |
Krystal Biotech
KRYS
|
$ 253.05
|
7.24 B
|
$ 145 M
|
40.3
|
19.7
|
$ 6.3
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 150.47
|
7.21 B
|
$ -197 M
|
-34.0
|
13.3
|
$ -4.5
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 111.83
|
6.82 B
|
$ -189 M
|
-35.7
|
40.9
|
$ -3.1
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 79.66
|
5.98 B
|
$ -316 M
|
-23.1
|
152.8
|
$ -3.5
|
 |
 |
PTC Therapeutics
PTCT
|
$ 77.41
|
5.95 B
|
$ 906 M
|
8.7
|
3.4
|
$ 9.1
|
 |
 |
Merus N.V.
MRUS
|
$ 91.9
|
5.9 B
|
$ -205 M
|
-15.3
|
105.1
|
$ -6.4
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 14.1
|
5.75 B
|
$ -48.8 M
|
-94.4
|
25.7
|
$ -0.2
|
 |
 |
Vaxcyte
PCVX
|
$ 46.25
|
5.64 B
|
$ -581 M
|
-10.2
|
∙ |
$ -4.6
|
 |
 |
Protagonist Therapeutics
PTGX
|
$ 87.51
|
5.39 B
|
$ 120 M
|
-47.0
|
127.2
|
$ -1.9
|
 |
 |
Praxis Precision Medicines
PRAX
|
$ 299.36
|
5.36 B
|
$ -198 M
|
-21.4
|
3124.0
|
$ -12.7
|
 |
 |
Longeveron
LGVN
|
$ 0.51
|
4.8 B
|
$ -21.7 M
|
-0.4
|
3103.9
|
$ -1.4
|
 |
 |
Alkermes plc
ALKS
|
$ 28.04
|
4.64 B
|
$ 287 M
|
16.0
|
3.2
|
$ 1.8
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 53.93
|
4.55 B
|
$ -601 M
|
-9.0
|
1432.4
|
$ -6.2
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 27.26
|
4.52 B
|
$ -213 M
|
-19.0
|
9.2
|
$ -1.4
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 44.96
|
4.49 B
|
$ -216 M
|
-14.3
|
43.6
|
$ -3.2
|
 |
 |
TG Therapeutics
TGTX
|
$ 30.47
|
4.43 B
|
$ -72.3 M
|
10.5
|
8.8
|
$ 2.9
|
 |
 |
Amicus Therapeutics
FOLD
|
$ 14.25
|
4.34 B
|
$ 46.2 M
|
-129.6
|
7.4
|
$ -0.1
|
 |
 |
ADMA Biologics
ADMA
|
$ 19.12
|
4.28 B
|
$ 176 M
|
35.1
|
8.8
|
$ 0.6
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 12.95
|
4 B
|
$ 545 M
|
92.8
|
1.4
|
$ 0.1
|
 |
 |
Viking Therapeutics
VKTX
|
$ 36.26
|
3.95 B
|
$ -201 M
|
-26.4
|
∙ |
$ -1.4
|
 |
 |
Immunovant
IMVT
|
$ 25.53
|
3.87 B
|
$ 324 K
|
-8.9
|
∙ |
$ -2.9
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 47.28
|
3.82 B
|
$ -274 M
|
-10.5
|
2017.1
|
$ -4.6
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 79.85
|
3.79 B
|
$ -6.4 M
|
-119.6
|
8.1
|
$ -0.7
|
 |
 |
Inhibrx
INBX
|
$ 79.04
|
3.73 B
|
$ -160 M
|
-19.2
|
8538.6
|
$ -4.2
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 194.83
|
3.56 B
|
$ 60.8 M
|
54.0
|
13.8
|
$ 3.6
|
 |
 |
Mersana Therapeutics
MRSN
|
$ 28.58
|
3.5 B
|
$ 1.7 M
|
-3.3
|
121.0
|
$ -8.9
|
 |
 |
Spruce Biosciences
SPRB
|
$ 84.73
|
3.5 B
|
$ -51.8 M
|
-2.5
|
482.3
|
$ -34.2
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 44.53
|
3.47 B
|
$ -216 M
|
-11.6
|
205.8
|
$ -3.9
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 28.34
|
3.43 B
|
$ -142 M
|
-26.8
|
15.7
|
$ -1.1
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 25.14
|
3.11 B
|
$ -471 M
|
-13.6
|
4.2
|
$ -1.8
|
 |
 |
Veracyte
VCYT
|
$ 42.75
|
3.11 B
|
$ 48.4 M
|
81.9
|
6.3
|
$ 0.5
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 81.44
|
3.06 B
|
$ -87.3 M
|
-40.3
|
8.8
|
$ -2.0
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 41.17
|
2.94 B
|
$ 24.2 M
|
351.2
|
5.8
|
$ 0.1
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 24.05
|
2.85 B
|
$ 152 M
|
14.3
|
5.1
|
$ 1.7
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 51.25
|
2.82 B
|
$ 4.48 M
|
572.9
|
4.2
|
$ 0.1
|
 |
 |
IDEAYA Biosciences
IDYA
|
$ 34.56
|
2.82 B
|
$ -129 M
|
-37.0
|
12.6
|
$ -1.0
|
 |
 |
Denali Therapeutics
DNLI
|
$ 16.45
|
2.71 B
|
$ -471 M
|
-5.9
|
8.3
|
$ -2.9
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 31.34
|
2.54 B
|
$ -251 M
|
-7.9
|
36.6
|
$ -4.0
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 17.74
|
2.45 B
|
$ -145 M
|
-12.8
|
49.1
|
$ -1.4
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 16.55
|
2.43 B
|
$ -60.1 M
|
-31.5
|
9.8
|
$ -0.5
|
 |
 |
Beam Therapeutics
BEAM
|
$ 27.61
|
2.27 B
|
$ -451 M
|
-6.2
|
57.7
|
$ -4.5
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 15.86
|
2.27 B
|
$ 60.9 M
|
31.9
|
8.7
|
$ 0.5
|
 |
 |
Liquidia Corporation
LQDA
|
$ 34.35
|
2.23 B
|
$ -99.1 M
|
-25.2
|
31.9
|
$ -1.4
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 37.79
|
2.15 B
|
$ 250 M
|
12.1
|
2.7
|
$ 3.2
|
 |
 |
Arcus Biosciences
RCUS
|
$ 23.14
|
2.08 B
|
$ -281 M
|
-7.2
|
7.6
|
$ -3.2
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 21.67
|
2.06 B
|
$ -254 M
|
-5.5
|
1.0
|
$ -4.0
|
 |
 |
Dynavax Technologies Corporation
DVAX
|
$ 15.37
|
2 B
|
$ -3.96 M
|
-61.6
|
5.9
|
$ -0.2
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 12.39
|
1.96 B
|
$ -136 M
|
-9.2
|
36.6
|
$ -1.4
|
 |
 |
Seres Therapeutics
MCRB
|
$ 14.73
|
1.89 B
|
$ -99.2 M
|
1.1
|
15.4
|
$ 14.1
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 19.32
|
1.87 B
|
$ -83 M
|
-15.5
|
415.6
|
$ -1.2
|
 |
 |
Vericel Corporation
VCEL
|
$ 37.5
|
1.83 B
|
$ -4.45 M
|
-236.7
|
7.7
|
$ -0.2
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 21.0
|
1.8 B
|
$ -130 M
|
-6.1
|
15.6
|
$ -3.5
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 19.7
|
1.78 B
|
$ -664 M
|
-5.7
|
8.9
|
$ -6.0
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 7.7
|
1.59 B
|
$ -37 M
|
-152.8
|
2.7
|
$ -0.0
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 49.56
|
1.59 B
|
$ 158 M
|
28.5
|
2.2
|
$ 1.8
|
 |
 |
MannKind Corporation
MNKD
|
$ 5.76
|
1.58 B
|
$ 67.5 M
|
58.0
|
5.2
|
$ 0.1
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 81.09
|
1.57 B
|
$ 140 M
|
83.4
|
2.0
|
$ 1.0
|
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 27.18
|
1.54 B
|
$ -381 M
|
2.4
|
41.1
|
$ 11.5
|
 |
 |
Kodiak Sciences
KOD
|
$ 29.09
|
1.52 B
|
$ -244 M
|
-7.2
|
∙ |
$ -4.1
|
 |
 |
Burford Capital Limited
BUR
|
$ 9.25
|
1.49 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
RAPT Therapeutics
RAPT
|
$ 35.89
|
1.46 B
|
$ -77 M
|
-6.8
|
357.4
|
$ -5.2
|
 |
 |
AnaptysBio
ANAB
|
$ 51.33
|
1.46 B
|
$ -143 M
|
-15.5
|
9.1
|
$ -3.2
|
 |
 |
Certara
CERT
|
$ 8.85
|
1.42 B
|
$ 65.2 M
|
445.0
|
3.5
|
$ 0.0
|
 |
 |
Stoke Therapeutics
STOK
|
$ 31.97
|
1.41 B
|
$ 33.6 M
|
73.8
|
7.4
|
$ 0.4
|
 |
 |
Taysha Gene Therapies
TSHA
|
$ 5.62
|
1.41 B
|
$ -107 M
|
-16.2
|
202.5
|
$ -0.4
|
 |
 |
Cidara Therapeutics
CDTX
|
$ 220.61
|
1.4 B
|
$ -15.9 M
|
-24.9
|
90.0
|
$ -8.9
|
 |
 |
Zymeworks
ZYME
|
$ 26.62
|
1.37 B
|
$ -268 M
|
-5.8
|
159.0
|
$ -4.6
|
 |
 |
Ardelyx
ARDX
|
$ 5.71
|
1.34 B
|
$ -107 M
|
-13.4
|
4.0
|
$ -0.4
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 26.86
|
1.3 B
|
$ 211 M
|
11.3
|
1.8
|
$ 2.4
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 19.13
|
1.28 B
|
$ -190 M
|
-6.7
|
15.6
|
$ -2.9
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 12.75
|
1.26 B
|
$ -39.2 M
|
-32.8
|
∙ |
$ -0.4
|
 |
 |
Innoviva
INVA
|
$ 19.68
|
1.23 B
|
$ 194 M
|
12.5
|
3.2
|
$ 1.6
|
 |
 |
uniQure N.V.
QURE
|
$ 24.47
|
1.19 B
|
$ -211 M
|
-6.6
|
94.8
|
$ -3.8
|
 |
 |
Relay Therapeutics
RLAY
|
$ 8.3
|
1.19 B
|
$ -356 M
|
-4.4
|
28.0
|
$ -1.9
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 41.95
|
1.17 B
|
$ -28.2 M
|
32.6
|
117.4
|
$ 1.3
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 25.54
|
1.16 B
|
$ -121 M
|
-13.4
|
∙ |
$ -2.0
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 7.4
|
1.09 B
|
$ 3.68 M
|
-26.6
|
4.2
|
$ -0.3
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 17.11
|
1.08 B
|
$ -296 M
|
-3.3
|
12.1
|
$ -5.2
|
 |
 |
Precigen
PGEN
|
$ 4.42
|
1.08 B
|
$ 14.9 M
|
-2.9
|
43.6
|
$ -1.4
|
 |
 |
Savara
SVRA
|
$ 6.34
|
1.05 B
|
$ -116 M
|
-12.7
|
1348.6
|
$ -0.5
|
 |
 |
Novavax
NVAX
|
$ 6.83
|
1.04 B
|
$ -17.9 M
|
3.6
|
1.0
|
$ 1.9
|
 |
 |
AbCellera Biologics
ABCL
|
$ 3.46
|
1.02 B
|
$ -229 M
|
-5.7
|
28.8
|
$ -0.6
|
 |
 |
Xencor
XNCR
|
$ 15.03
|
978 M
|
$ -169 M
|
-8.2
|
8.6
|
$ -1.9
|
 |
 |
Omeros Corporation
OMER
|
$ 16.5
|
960 M
|
$ -128 M
|
-7.8
|
10.2
|
$ -2.0
|
 |
 |
Theravance Biopharma
TBPH
|
$ 18.7
|
913 M
|
$ -131 M
|
33.8
|
12.0
|
$ 0.6
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 2.96
|
908 M
|
$ -24.3 M
|
-22.5
|
∙ |
$ -0.1
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 9.14
|
903 M
|
$ -477 M
|
-2.2
|
17.3
|
$ -4.3
|
 |
 |
Kura Oncology
KURA
|
$ 10.29
|
887 M
|
$ -118 M
|
-3.7
|
18.2
|
$ -2.9
|
 |
 |
FibroGen
FGEN
|
$ 8.76
|
852 M
|
$ -263 M
|
0.2
|
240.7
|
$ 39.6
|
 |
 |
Arvinas
ARVN
|
$ 11.79
|
848 M
|
$ -101 M
|
-14.1
|
2.4
|
$ -0.9
|
 |
 |
Galecto
GLTO
|
$ 31.14
|
827 M
|
$ -13 M
|
-3.4
|
∙ |
$ -10.3
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 30.09
|
806 M
|
$ -90.2 M
|
-14.6
|
45.6
|
$ -2.0
|
 |
 |
Sana Biotechnology
SANA
|
$ 4.14
|
805 M
|
$ -237 M
|
-4.4
|
∙ |
$ -1.0
|
 |
 |
Vir Biotechnology
VIR
|
$ 5.95
|
798 M
|
$ -669 M
|
-1.3
|
116.7
|
$ -4.6
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 12.12
|
798 M
|
$ 16.5 M
|
102.8
|
7.7
|
$ 0.1
|
 |
 |
Replimune Group
REPL
|
$ 9.84
|
793 M
|
$ -296 M
|
-3.0
|
∙ |
$ -3.3
|
 |
 |
Geron Corporation
GERN
|
$ 1.37
|
782 M
|
$ -152 M
|
-11.5
|
4.8
|
$ -0.1
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.71
|
782 M
|
$ -78.1 M
|
-18.4
|
55.2
|
$ -0.3
|
 |
 |
Keros Therapeutics
KROS
|
$ 20.7
|
775 M
|
$ 38 M
|
16.0
|
3.2
|
$ 1.3
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 4.34
|
772 M
|
$ -9.29 M
|
-0.5
|
163.6
|
$ -9.6
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 15.18
|
754 M
|
$ -159 M
|
-4.0
|
17.2
|
$ -3.8
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 42.47
|
747 M
|
$ 119 M
|
7.0
|
2.8
|
$ 6.2
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 11.43
|
739 M
|
$ -651 M
|
-0.7
|
1.2
|
$ -15.0
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 3.89
|
728 M
|
$ -164 M
|
-7.0
|
2.6
|
$ -0.6
|
 |
 |
Annexon
ANNX
|
$ 5.01
|
688 M
|
$ -180 M
|
-4.3
|
∙ |
$ -1.2
|
 |
 |
Sutro Biopharma
STRO
|
$ 11.08
|
667 M
|
$ -179 M
|
-4.9
|
6.8
|
$ -2.3
|
 |
 |
Passage Bio
PASG
|
$ 11.03
|
666 M
|
$ -54.7 M
|
-0.9
|
∙ |
$ -11.8
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 22.94
|
661 M
|
$ -112 M
|
-7.5
|
6.7
|
$ -3.1
|
 |
 |
CorMedix
CRMD
|
$ 12.72
|
647 M
|
$ 47.5 M
|
6.3
|
3.3
|
$ 2.0
|
 |
 |
REGENXBIO
RGNX
|
$ 14.14
|
618 M
|
$ -246 M
|
-2.9
|
6.3
|
$ -4.8
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 9.45
|
607 M
|
$ -85.3 M
|
-4.0
|
196.7
|
$ -2.5
|
 |
 |
Cullinan Management
CGEM
|
$ 10.07
|
589 M
|
$ -190 M
|
-3.2
|
31.3
|
$ -3.2
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 8.32
|
580 M
|
$ -112 M
|
-4.8
|
∙ |
$ -1.7
|
 |
 |
Aquestive Therapeutics
AQST
|
$ 6.42
|
557 M
|
$ -30.5 M
|
-13.5
|
9.1
|
$ -0.4
|
 |
 |
Benitec Biopharma
BNTC
|
$ 13.38
|
551 M
|
$ -34.3 M
|
-13.5
|
4135.1
|
$ -1.0
|
 |
 |
Ironwood Pharmaceuticals
IRWD
|
$ 3.21
|
511 M
|
$ 113 M
|
16.8
|
1.5
|
$ 0.2
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 9.35
|
503 M
|
$ -256 M
|
-1.8
|
48.2
|
$ -5.2
|
 |
 |
Gossamer Bio
GOSS
|
$ 3.22
|
491 M
|
$ -59.8 M
|
-4.7
|
11.1
|
$ -0.7
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.87
|
477 M
|
$ -258 M
|
-1.6
|
6.9
|
$ -1.0
|
 |
 |
Kezar Life Sciences
KZR
|
$ 6.32
|
459 M
|
$ -64.9 M
|
-0.8
|
65.7
|
$ -8.4
|
 |
 |
SIGA Technologies
SIGA
|
$ 6.25
|
446 M
|
$ 50.6 M
|
15.0
|
4.5
|
$ 0.4
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 3.36
|
443 M
|
$ -264 M
|
-2.7
|
1.9
|
$ -1.2
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 0.68
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 7.75
|
438 M
|
$ -160 M
|
-3.7
|
29.4
|
$ -2.2
|
 |
 |
Ocugen
OCGN
|
$ 1.49
|
434 M
|
$ -74.6 M
|
-5.6
|
71.6
|
$ -0.2
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 16.8
|
431 M
|
$ -2.42 M
|
-80.5
|
6.3
|
$ -0.2
|
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 1.09
|
428 M
|
$ -59.3 M
|
6.0
|
9.2
|
$ 0.2
|
 |
 |
Immunome
IMNM
|
$ 21.41
|
425 M
|
$ -154 M
|
-8.6
|
41.7
|
$ -2.5
|
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 7.27
|
423 M
|
$ -95.2 M
|
-6.2
|
2.0
|
$ -1.1
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 6.78
|
395 M
|
$ -260 M
|
-1.9
|
16.0
|
$ -3.5
|
 |
 |
Cerus Corporation
CERS
|
$ 2.06
|
380 M
|
$ -31.5 M
|
-17.1
|
7.4
|
$ -0.1
|
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.17
|
374 M
|
$ -124 M
|
-4.4
|
8.6
|
$ -0.3
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 8.16
|
370 M
|
$ -25.5 M
|
-1.6
|
12.9
|
$ -5.0
|
 |
 |
Can-Fite BioPharma Ltd.
CANF
|
$ 0.17
|
370 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
NextCure
NXTC
|
$ 13.2
|
369 M
|
$ -76.6 M
|
-0.6
|
5.2
|
$ -19.8
|
 |
 |
Generation Bio Co.
GBIO
|
$ 5.55
|
358 M
|
$ -59.2 M
|
-0.9
|
19.4
|
$ -6.4
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 7.42
|
356 M
|
$ -37.9 M
|
-12.6
|
∙ |
$ -0.6
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 4.22
|
356 M
|
$ -53.6 M
|
62.7
|
4.5
|
$ 0.1
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 3.47
|
329 M
|
$ -251 M
|
-1.5
|
∙ |
$ -2.3
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 5.14
|
328 M
|
$ -24.4 M
|
-3.8
|
951.2
|
$ -1.3
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 24.62
|
320 M
|
$ -14.2 M
|
-20.3
|
∙ |
$ -1.0
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 3.66
|
312 M
|
$ -51.1 M
|
-6.4
|
∙ |
$ -0.6
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 5.16
|
307 M
|
$ -51 M
|
-7.5
|
∙ |
$ -0.7
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.63
|
306 M
|
$ -3.97 M
|
-8.3
|
1.4
|
$ -0.2
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 3.62
|
305 M
|
$ -166 M
|
-2.1
|
1.9
|
$ -1.7
|
 |
 |
Puma Biotechnology
PBYI
|
$ 6.16
|
300 M
|
$ 45.4 M
|
7.9
|
1.3
|
$ 0.8
|
 |
 |
Athira Pharma
ATHA
|
$ 7.57
|
291 M
|
$ -52.5 M
|
-0.8
|
∙ |
$ -9.6
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 5.2
|
285 M
|
$ -83 M
|
-4.7
|
10.0
|
$ -1.1
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.63
|
281 M
|
$ -33.3 M
|
-5.5
|
24.3
|
$ -0.3
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 16.38
|
279 M
|
$ -91.1 M
|
-0.5
|
26.2
|
$ -33.0
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 8.2
|
267 M
|
$ -22.5 M
|
-12.1
|
535.4
|
$ -0.7
|
 |
 |
Altimmune
ALT
|
$ 3.69
|
262 M
|
$ -95.3 M
|
-3.6
|
13739.2
|
$ -1.1
|
 |
 |
Kamada Ltd.
KMDA
|
$ 7.04
|
260 M
|
$ 6.96 M
|
54.3
|
4.5
|
$ 0.1
|
 |
 |
Galectin Therapeutics
GALT
|
$ 4.09
|
255 M
|
$ -36 M
|
-6.9
|
-637.5
|
$ -0.6
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 66.07
|
250 M
|
$ -12.1 M
|
-43.6
|
∙ |
$ -1.6
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 6.45
|
233 M
|
$ -31.2 M
|
-4.2
|
7506.0
|
$ -1.5
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 3.0
|
232 M
|
$ -63.6 M
|
-6.3
|
21.5
|
$ -0.5
|
 |
 |
Sensei Biotherapeutics
SNSE
|
$ 9.0
|
226 M
|
$ -31.2 M
|
-0.7
|
∙ |
$ -13.6
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 1.36
|
213 M
|
$ -295 M
|
-1.4
|
2272.2
|
$ -1.0
|
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 7.74
|
206 M
|
$ -20.6 M
|
-20.8
|
5.5
|
$ -0.4
|
 |
 |
Heron Therapeutics
HRTX
|
$ 1.31
|
200 M
|
$ -72.5 M
|
-9.8
|
1.3
|
$ -0.1
|
 |
 |
Rezolute
RZLT
|
$ 2.42
|
184 M
|
$ -67 M
|
-3.0
|
∙ |
$ -0.9
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 2.92
|
176 M
|
$ -126 M
|
-1.6
|
15.6
|
$ -1.5
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 3.96
|
174 M
|
$ -63.6 M
|
-2.3
|
∙ |
$ -1.7
|
 |
 |
Voyager Therapeutics
VYGR
|
$ 4.04
|
174 M
|
$ 95.1 M
|
-2.4
|
3.5
|
$ -1.7
|
 |
 |
Verastem
VSTM
|
$ 7.71
|
170 M
|
$ -109 M
|
-2.4
|
6.8
|
$ -3.3
|
 |
 |
Editas Medicine
EDIT
|
$ 2.06
|
170 M
|
$ -242 M
|
-0.8
|
11.3
|
$ -2.6
|
 |
 |
Lyra Therapeutics
LYRA
|
$ 3.4
|
169 M
|
$ -72.2 M
|
-0.2
|
298.3
|
$ -18.1
|
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 6.15
|
166 M
|
$ -56.6 M
|
-3.6
|
1.2
|
$ -1.7
|
 |
 |
Forte Biosciences
FBRX
|
$ 25.9
|
166 M
|
$ -30.3 M
|
-3.6
|
10.0
|
$ -7.9
|
 |
 |
Assembly Biosciences
ASMB
|
$ 33.23
|
152 M
|
$ -63.1 M
|
-7.0
|
4.2
|
$ -4.7
|
 |
 |
Shattuck Labs
STTK
|
$ 3.5
|
149 M
|
$ -76.3 M
|
-3.4
|
21.2
|
$ -1.0
|
 |
 |
vTv Therapeutics
VTVT
|
$ 37.34
|
147 M
|
$ -23.5 M
|
∙ |
29.3
|
∙ |
 |
 |
Alector
ALEC
|
$ 1.51
|
146 M
|
$ -178 M
|
-1.0
|
4.6
|
$ -1.5
|
 |
 |
C4 Therapeutics
CCCC
|
$ 2.04
|
142 M
|
$ -119 M
|
-1.4
|
3.6
|
$ -1.5
|
 |
 |
Cardiff Oncology
CRDF
|
$ 2.97
|
142 M
|
$ -53.4 M
|
-3.9
|
297.9
|
$ -0.8
|
 |
 |
Anika Therapeutics
ANIK
|
$ 9.53
|
140 M
|
$ -6.4 M
|
-3.4
|
1.3
|
$ -2.8
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.49
|
137 M
|
$ -91.7 M
|
-2.6
|
∙ |
$ -1.0
|
 |
 |
Compugen Ltd.
CGEN
|
$ 1.49
|
133 M
|
∙ |
∙ |
16.9
|
∙ |
 |
 |
Atara Biotherapeutics
ATRA
|
$ 17.74
|
133 M
|
$ -27.9 M
|
35.5
|
0.8
|
$ 0.5
|
 |
 |
Coherus BioSciences
CHRS
|
$ 1.33
|
125 M
|
$ -181 M
|
0.8
|
3.5
|
$ 1.7
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.3
|
121 M
|
$ -80.8 M
|
-3.1
|
3.1
|
$ -0.7
|
 |
 |
Codexis
CDXS
|
$ 1.65
|
121 M
|
$ -63.9 M
|
-1.8
|
2.7
|
$ -0.9
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 1.79
|
121 M
|
$ -12.8 M
|
-179.0
|
2.0
|
$ -0.0
|
 |
 |
Seer
SEER
|
$ 1.84
|
117 M
|
$ -96.5 M
|
-1.4
|
8.2
|
$ -1.4
|
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 2.91
|
117 M
|
$ -20.7 M
|
3.7
|
29.8
|
$ 0.8
|
 |
 |
Ovid Therapeutics
OVID
|
$ 1.66
|
117 M
|
$ -43 M
|
-4.3
|
18.7
|
$ -0.4
|
 |
 |
Cellectis S.A.
CLLS
|
$ 4.95
|
116 M
|
$ -106 M
|
-2.0
|
7.6
|
$ -2.4
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 5.41
|
116 M
|
$ -79.6 M
|
5.0
|
18.7
|
$ 1.1
|
 |
 |
Fate Therapeutics
FATE
|
$ 0.98
|
111 M
|
$ -186 M
|
-0.8
|
13.8
|
$ -1.3
|
 |
 |
Protara Therapeutics
TARA
|
$ 5.34
|
110 M
|
$ -43.3 M
|
-3.8
|
38.7
|
$ -1.4
|
 |
 |
Repare Therapeutics
RPTX
|
$ 2.56
|
109 M
|
$ 22 M
|
-1.4
|
∙ |
$ -1.8
|
 |
 |
ADC Therapeutics SA
ADCT
|
$ 3.51
|
105 M
|
$ -239 M
|
-1.3
|
6.2
|
$ -2.8
|
 |
 |
CASI Pharmaceuticals
CASI
|
$ 0.77
|
105 M
|
$ -27.1 M
|
-0.4
|
2.8
|
$ -1.7
|
 |
 |
Adagene
ADAG
|
$ 1.82
|
102 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
BiomX
PHGE
|
$ 1.96
|
101 M
|
$ -26.2 M
|
3.9
|
∙ |
$ 0.5
|
 |
 |
MacroGenics
MGNX
|
$ 1.6
|
99.1 M
|
$ -145 M
|
-32.0
|
0.4
|
$ -0.0
|
 |
 |
Cassava Sciences
SAVA
|
$ 2.1
|
97.3 M
|
$ -112 M
|
-1.0
|
2.5
|
$ -2.2
|
 |
 |
Champions Oncology
CSBR
|
$ 6.93
|
94.7 M
|
$ 1.27 M
|
-231.3
|
1.8
|
$ -0.0
|
 |
 |
SELLAS Life Sciences Group
SLS
|
$ 3.33
|
92.5 M
|
$ -39.5 M
|
-9.5
|
6.6
|
$ -0.3
|
 |
 |
Nkarta
NKTX
|
$ 1.84
|
90.2 M
|
$ -116 M
|
-1.3
|
764.6
|
$ -1.4
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 1.36
|
89 M
|
$ -166 M
|
-0.7
|
2.3
|
$ -2.0
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 4.44
|
88 M
|
$ 448 K
|
-3.2
|
∙ |
$ -1.4
|
 |
 |
Entera Bio Ltd.
ENTX
|
$ 1.82
|
83.5 M
|
$ -8.21 M
|
3.4
|
333.7
|
$ 0.5
|
 |
 |
Atossa Therapeutics
ATOS
|
$ 0.65
|
82 M
|
$ -29.7 M
|
-2.6
|
729.8
|
$ -0.2
|
 |
 |
Fortress Biotech
FBIO
|
$ 3.59
|
74.6 M
|
$ -87.3 M
|
-6.1
|
1.2
|
$ -0.6
|
 |
 |
Pliant Therapeutics
PLRX
|
$ 1.23
|
74.5 M
|
$ -193 M
|
-0.4
|
9.2
|
$ -3.0
|
 |