 |
Eli Lilly and Company
LLY
|
$ 906.7
|
814 B
|
$ 2.37 B
|
66.8
|
16.1
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 235.37
|
567 B
|
$ 9.42 B
|
23.5
|
6.2
|
$ 10.1
|
 |
 |
AbbVie
ABBV
|
$ 205.07
|
363 B
|
$ 15.1 B
|
92.9
|
6.2
|
$ 2.2
|
 |
 |
Merck & Co.
MRK
|
$ 114.18
|
286 B
|
$ 2.86 B
|
15.6
|
4.4
|
$ 7.3
|
 |
 |
Novartis AG
NVS
|
$ 146.03
|
227 B
|
$ 10.7 B
|
25.5
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 347.8
|
187 B
|
$ 12.4 B
|
26.4
|
7.1
|
$ 13.2
|
 |
 |
Gilead Sciences
GILD
|
$ 137.21
|
171 B
|
$ 9.3 B
|
23.2
|
6.0
|
$ 6.1
|
 |
 |
Pfizer
PFE
|
$ 26.97
|
153 B
|
$ 6.66 B
|
11.2
|
2.5
|
$ 2.4
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 57.48
|
117 B
|
$ 11 B
|
17.7
|
2.5
|
$ 3.3
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 454.0
|
116 B
|
$ 4.29 B
|
30.9
|
10.1
|
$ 14.8
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 732.87
|
76.7 B
|
$ 4.1 B
|
15.9
|
5.5
|
$ 46.5
|
 |
 |
Zoetis
ZTS
|
$ 115.67
|
51.3 B
|
$ 487 M
|
18.8
|
5.4
|
$ 6.2
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 312.17
|
40.9 B
|
$ -361 M
|
-159.5
|
16.1
|
$ -2.0
|
 |
 |
Axon Enterprise
AXON
|
$ 496.27
|
37.6 B
|
$ 89.9 M
|
129.8
|
20.5
|
$ 3.9
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 28.73
|
32.9 B
|
$ 2.81 B
|
68.5
|
2.0
|
$ 0.4
|
 |
 |
Insmed Incorporated
INSM
|
$ 136.0
|
27.1 B
|
$ -1.06 B
|
-22.8
|
74.6
|
$ -6.3
|
 |
 |
Biogen
BIIB
|
$ 181.46
|
26.6 B
|
$ 2.03 B
|
14.5
|
2.7
|
$ 12.7
|
 |
 |
argenx SE
ARGX
|
$ 663.93
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
United Therapeutics Corporation
UTHR
|
$ 524.28
|
23.2 B
|
$ 1.42 B
|
19.4
|
7.6
|
$ 27.2
|
 |
 |
Moderna
MRNA
|
$ 51.38
|
20 B
|
$ -2.09 B
|
-10.2
|
6.5
|
$ -5.1
|
 |
 |
Zai Lab Limited
ZLAB
|
$ 18.09
|
19.8 B
|
$ -218 M
|
-124.1
|
46.9
|
$ -0.2
|
 |
 |
Royalty Pharma plc
RPRX
|
$ 45.36
|
19.5 B
|
$ 1.1 B
|
18.1
|
8.4
|
$ 2.5
|
 |
 |
Legend Biotech Corporation
LEGN
|
$ 17.41
|
18.7 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Revolution Medicines
RVMD
|
$ 95.78
|
18.2 B
|
$ -989 M
|
-19.9
|
809.9
|
$ -5.0
|
 |
 |
Incyte Corporation
INCY
|
$ 90.78
|
17.7 B
|
$ 573 M
|
65.5
|
4.1
|
$ 1.4
|
 |
 |
Longeveron
LGVN
|
$ 0.98
|
17.2 B
|
$ -21.7 M
|
-0.8
|
12140.6
|
$ -1.4
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 72.22
|
13.7 B
|
$ -373 M
|
-0.1
|
144.5
|
$ -791.5
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 68.54
|
13.1 B
|
$ -603 M
|
-22.8
|
57.9
|
$ -3.1
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 127.68
|
12.7 B
|
$ 124 M
|
42.0
|
5.2
|
$ 3.1
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 13.94
|
12 B
|
$ -59 M
|
-276.4
|
113.5
|
$ -0.0
|
 |
 |
Summit Therapeutics
SMMT
|
$ 15.51
|
11.6 B
|
$ -609 M
|
-12.7
|
5836.1
|
$ -1.2
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 70.99
|
11.4 B
|
$ -451 M
|
-46.0
|
12.1
|
$ -1.6
|
 |
 |
Exelixis
EXEL
|
$ 41.27
|
11.2 B
|
$ 363 M
|
17.3
|
5.0
|
$ 2.4
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 180.62
|
11 B
|
$ 73.8 M
|
-32.4
|
2.7
|
$ -5.6
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 54.13
|
10.4 B
|
$ 790 M
|
16.5
|
3.5
|
$ 3.3
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 441.16
|
9.9 B
|
$ -389 M
|
-29.8
|
14.6
|
$ -15.2
|
 |
 |
Mesoblast Limited
MESO
|
$ 14.36
|
9.32 B
|
∙ |
-2.0
|
968.5
|
$ -7.6
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 51.48
|
8.11 B
|
$ 276 M
|
60.7
|
6.8
|
$ 0.8
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 156.92
|
7.81 B
|
$ -197 M
|
-35.5
|
14.4
|
$ -4.5
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 63.43
|
7.6 B
|
$ 736 M
|
12.9
|
6.1
|
$ 4.9
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 56.33
|
7.53 B
|
$ -441 M
|
-15.0
|
25.6
|
$ -3.8
|
 |
 |
Vaxcyte
PCVX
|
$ 54.72
|
7.45 B
|
$ -581 M
|
-11.6
|
∙ |
$ -4.6
|
 |
 |
Krystal Biotech
KRYS
|
$ 251.68
|
7.28 B
|
$ 145 M
|
41.2
|
20.4
|
$ 6.3
|
 |
 |
Can-Fite BioPharma Ltd.
CANF
|
$ 3.17
|
6.9 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Praxis Precision Medicines
PRAX
|
$ 298.31
|
6.71 B
|
$ -198 M
|
-23.4
|
4297.3
|
$ -12.7
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 77.91
|
6.58 B
|
$ -316 M
|
-22.5
|
167.7
|
$ -3.5
|
 |
 |
Protagonist Therapeutics
PTGX
|
$ 98.87
|
6.29 B
|
$ 120 M
|
-53.5
|
149.4
|
$ -1.9
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 14.49
|
6.01 B
|
$ -48.8 M
|
-100.0
|
27.7
|
$ -0.2
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 87.45
|
5.68 B
|
$ -189 M
|
-29.0
|
35.4
|
$ -3.1
|
 |
 |
PTC Therapeutics
PTCT
|
$ 65.3
|
5.19 B
|
$ 906 M
|
7.4
|
3.0
|
$ 9.1
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 44.64
|
5.12 B
|
$ -216 M
|
-14.2
|
49.7
|
$ -3.2
|
 |
 |
Alkermes plc
ALKS
|
$ 28.15
|
4.64 B
|
$ 287 M
|
16.0
|
3.2
|
$ 1.8
|
 |
 |
Amicus Therapeutics
FOLD
|
$ 14.43
|
4.45 B
|
$ 46.2 M
|
-130.7
|
7.5
|
$ -0.1
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 88.51
|
4.44 B
|
$ -6.4 M
|
-137.4
|
9.8
|
$ -0.7
|
 |
 |
TG Therapeutics
TGTX
|
$ 30.09
|
4.34 B
|
$ -72.3 M
|
10.3
|
8.6
|
$ 2.9
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 54.94
|
4.28 B
|
$ -216 M
|
-14.3
|
253.8
|
$ -3.9
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 46.24
|
4.16 B
|
$ -601 M
|
-7.6
|
1299.3
|
$ -6.2
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 204.81
|
3.75 B
|
$ 60.8 M
|
57.8
|
14.8
|
$ 3.6
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 11.83
|
3.71 B
|
$ 545 M
|
88.1
|
1.3
|
$ 0.1
|
 |
 |
Viking Therapeutics
VKTX
|
$ 32.33
|
3.64 B
|
$ -201 M
|
-24.1
|
∙ |
$ -1.4
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 34.64
|
3.6 B
|
$ 80.9 M
|
29.4
|
4.8
|
$ 1.2
|
 |
 |
Immunovant
IMVT
|
$ 22.98
|
3.48 B
|
$ 324 K
|
-8.4
|
∙ |
$ -2.8
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 20.74
|
3.44 B
|
$ -213 M
|
-14.3
|
6.9
|
$ -1.4
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 46.08
|
3.42 B
|
$ 24.2 M
|
380.2
|
6.6
|
$ 0.1
|
 |
 |
ADMA Biologics
ADMA
|
$ 14.32
|
3.41 B
|
$ 176 M
|
27.3
|
7.3
|
$ 0.6
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 35.57
|
3.35 B
|
$ -274 M
|
-7.8
|
1742.0
|
$ -4.6
|
 |
 |
Denali Therapeutics
DNLI
|
$ 20.17
|
3.32 B
|
$ -471 M
|
-6.9
|
9.7
|
$ -2.9
|
 |
 |
Liquidia Corporation
LQDA
|
$ 36.41
|
3.13 B
|
$ -99.1 M
|
-27.1
|
45.4
|
$ -1.4
|
 |
 |
Akari Therapeutics, Plc
AKTX
|
$ 0.13
|
3.11 B
|
$ -15.1 M
|
∙ |
∙ |
∙ |
 |
 |
IDEAYA Biosciences
IDYA
|
$ 32.75
|
2.9 B
|
$ -129 M
|
-34.3
|
12.7
|
$ -1.0
|
 |
 |
Inhibrx
INBX
|
$ 60.92
|
2.87 B
|
$ -160 M
|
-15.4
|
6885.9
|
$ -4.2
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 22.21
|
2.83 B
|
$ -142 M
|
-21.2
|
13.1
|
$ -1.1
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 22.79
|
2.79 B
|
$ 152 M
|
13.1
|
4.8
|
$ 1.7
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 26.98
|
2.75 B
|
$ -251 M
|
-6.9
|
40.0
|
$ -4.0
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 47.76
|
2.7 B
|
$ 4.48 M
|
542.7
|
4.0
|
$ 0.1
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 64.51
|
2.7 B
|
$ -87.3 M
|
-32.9
|
8.0
|
$ -2.0
|
 |
 |
Veracyte
VCYT
|
$ 31.84
|
2.5 B
|
$ 48.4 M
|
63.0
|
5.2
|
$ 0.5
|
 |
 |
Beam Therapeutics
BEAM
|
$ 24.63
|
2.44 B
|
$ -451 M
|
-5.6
|
62.4
|
$ -4.5
|
 |
 |
Arcus Biosciences
RCUS
|
$ 21.64
|
2.32 B
|
$ -281 M
|
-7.0
|
8.8
|
$ -3.2
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 17.21
|
2.17 B
|
$ -471 M
|
-9.8
|
3.1
|
$ -1.8
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 24.23
|
2.07 B
|
$ -130 M
|
-6.9
|
17.7
|
$ -3.5
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 13.58
|
2.06 B
|
$ -60.1 M
|
-25.5
|
8.1
|
$ -0.5
|
 |
 |
Celldex Therapeutics
CLDX
|
$ 30.9
|
2.05 B
|
$ -159 M
|
-9.1
|
280.4
|
$ -3.3
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 72.97
|
2.03 B
|
$ -28.2 M
|
63.8
|
229.8
|
$ 1.3
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 9.7
|
2 B
|
$ -37 M
|
-196.2
|
3.5
|
$ -0.0
|
 |
 |
Stoke Therapeutics
STOK
|
$ 33.51
|
1.98 B
|
$ 33.6 M
|
77.2
|
10.5
|
$ 0.4
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 11.76
|
1.98 B
|
$ -145 M
|
-8.7
|
40.8
|
$ -1.4
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 19.87
|
1.96 B
|
$ -664 M
|
-3.4
|
5.8
|
$ -6.0
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 14.02
|
1.88 B
|
$ 60.9 M
|
27.6
|
7.0
|
$ 0.5
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 19.09
|
1.85 B
|
$ -83 M
|
-15.8
|
423.8
|
$ -1.2
|
 |
 |
Avidity Biosciences
RNA
|
$ 13.13
|
1.81 B
|
$ -586 M
|
-18.1
|
495.7
|
$ -4.0
|
 |
 |
AnaptysBio
ANAB
|
$ 62.37
|
1.79 B
|
$ -143 M
|
-20.1
|
11.9
|
$ -3.2
|
 |
 |
Immunome
IMNM
|
$ 20.01
|
1.75 B
|
$ -154 M
|
-8.2
|
176.3
|
$ -2.5
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 16.69
|
1.67 B
|
$ -254 M
|
-4.1
|
0.8
|
$ -4.0
|
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 27.86
|
1.62 B
|
$ -381 M
|
2.4
|
41.8
|
$ 11.5
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 27.72
|
1.59 B
|
$ 250 M
|
8.8
|
2.0
|
$ 3.2
|
 |
 |
Vericel Corporation
VCEL
|
$ 31.41
|
1.58 B
|
$ -4.45 M
|
-204.6
|
6.8
|
$ -0.2
|
 |
 |
Novavax
NVAX
|
$ 9.62
|
1.56 B
|
$ -17.9 M
|
5.2
|
1.5
|
$ 1.9
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 8.18
|
1.53 B
|
$ -136 M
|
-6.0
|
28.6
|
$ -1.4
|
 |
 |
Innoviva
INVA
|
$ 21.7
|
1.46 B
|
$ 194 M
|
13.9
|
3.8
|
$ 1.6
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 74.67
|
1.44 B
|
$ 140 M
|
75.6
|
1.8
|
$ 1.0
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 10.61
|
1.43 B
|
$ -39.2 M
|
-27.4
|
∙ |
$ -0.4
|
 |
 |
Relay Therapeutics
RLAY
|
$ 9.91
|
1.42 B
|
$ -356 M
|
-5.2
|
32.8
|
$ -1.9
|
 |
 |
Taysha Gene Therapies
TSHA
|
$ 4.4
|
1.41 B
|
$ -107 M
|
-12.7
|
158.7
|
$ -0.4
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 29.1
|
1.35 B
|
$ -90.2 M
|
-15.4
|
83.6
|
$ -2.0
|
 |
 |
Burford Capital Limited
BUR
|
$ 7.7
|
1.29 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Ardelyx
ARDX
|
$ 5.31
|
1.28 B
|
$ -107 M
|
-12.8
|
3.9
|
$ -0.4
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 12.84
|
1.27 B
|
$ -477 M
|
-3.0
|
24.2
|
$ -4.3
|
 |
 |
Vir Biotechnology
VIR
|
$ 9.1
|
1.26 B
|
$ -669 M
|
-2.1
|
188.1
|
$ -4.6
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 14.43
|
1.25 B
|
$ -190 M
|
-5.2
|
15.6
|
$ -2.9
|
 |
 |
Sutro Biopharma
STRO
|
$ 20.68
|
1.24 B
|
$ -179 M
|
-9.1
|
12.8
|
$ -2.3
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 14.08
|
1.23 B
|
$ -121 M
|
-7.6
|
∙ |
$ -2.0
|
 |
 |
Zymeworks
ZYME
|
$ 23.32
|
1.2 B
|
$ -268 M
|
-5.2
|
141.2
|
$ -4.6
|
 |
 |
Kodiak Sciences
KOD
|
$ 22.25
|
1.17 B
|
$ -244 M
|
-5.5
|
∙ |
$ -4.1
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 35.44
|
1.12 B
|
$ 158 M
|
20.7
|
1.6
|
$ 1.8
|
 |
 |
Savara
SVRA
|
$ 4.96
|
1.1 B
|
$ -116 M
|
-10.1
|
1443.4
|
$ -0.5
|
 |
 |
Seres Therapeutics
MCRB
|
$ 8.5
|
1.09 B
|
$ -99.2 M
|
0.6
|
9.2
|
$ 14.1
|
 |
 |
AbCellera Biologics
ABCL
|
$ 3.4
|
1.02 B
|
$ -229 M
|
-5.6
|
28.7
|
$ -0.6
|
 |
 |
Certara
CERT
|
$ 6.15
|
986 M
|
$ 65.2 M
|
319.0
|
2.5
|
$ 0.0
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 11.16
|
980 M
|
$ -112 M
|
-6.5
|
∙ |
$ -1.7
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 10.9
|
974 M
|
$ 16.5 M
|
88.5
|
9.0
|
$ 0.1
|
 |
 |
Geron Corporation
GERN
|
$ 1.46
|
973 M
|
$ -152 M
|
-12.9
|
6.3
|
$ -0.1
|
 |
 |
uniQure N.V.
QURE
|
$ 16.09
|
925 M
|
$ -211 M
|
-4.0
|
68.5
|
$ -3.8
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 19.5
|
911 M
|
$ 211 M
|
8.1
|
1.2
|
$ 2.4
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 2.65
|
908 M
|
$ -24.3 M
|
-20.8
|
∙ |
$ -0.1
|
 |
 |
Xencor
XNCR
|
$ 12.13
|
901 M
|
$ -169 M
|
-6.5
|
7.8
|
$ -1.9
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 5.44
|
873 M
|
$ 3.68 M
|
-19.9
|
3.4
|
$ -0.3
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 17.62
|
848 M
|
$ -112 M
|
-6.1
|
9.1
|
$ -3.1
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 17.0
|
844 M
|
$ -159 M
|
-4.4
|
18.6
|
$ -3.8
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 11.21
|
817 M
|
$ -296 M
|
-2.1
|
8.9
|
$ -5.2
|
 |
 |
Precigen
PGEN
|
$ 3.28
|
802 M
|
$ 14.9 M
|
-2.3
|
34.9
|
$ -1.4
|
 |
 |
Sensei Biotherapeutics
SNSE
|
$ 31.56
|
793 M
|
$ -31.2 M
|
-2.2
|
∙ |
$ -13.6
|
 |
 |
Sana Biotechnology
SANA
|
$ 3.11
|
788 M
|
$ -237 M
|
-3.1
|
∙ |
$ -1.0
|
 |
 |
Arvinas
ARVN
|
$ 10.94
|
776 M
|
$ -101 M
|
-13.0
|
2.2
|
$ -0.9
|
 |
 |
Cullinan Management
CGEM
|
$ 12.74
|
768 M
|
$ -190 M
|
-4.1
|
41.6
|
$ -3.2
|
 |
 |
MannKind Corporation
MNKD
|
$ 2.47
|
755 M
|
$ 67.5 M
|
25.2
|
2.5
|
$ 0.1
|
 |
 |
Kura Oncology
KURA
|
$ 8.26
|
724 M
|
$ -118 M
|
-2.9
|
14.7
|
$ -2.9
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.24
|
704 M
|
$ -78.1 M
|
-16.8
|
50.5
|
$ -0.3
|
 |
 |
Annexon
ANNX
|
$ 5.11
|
702 M
|
$ -180 M
|
-4.6
|
∙ |
$ -1.2
|
 |
 |
Theravance Biopharma
TBPH
|
$ 14.33
|
700 M
|
$ -131 M
|
25.0
|
8.8
|
$ 0.6
|
 |
 |
Atossa Therapeutics
ATOS
|
$ 5.33
|
672 M
|
$ -29.7 M
|
-20.5
|
5672.6
|
$ -0.2
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 13.33
|
640 M
|
$ -37.9 M
|
-23.1
|
∙ |
$ -0.6
|
 |
 |
Omeros Corporation
OMER
|
$ 11.0
|
640 M
|
$ -128 M
|
-5.4
|
7.2
|
$ -2.0
|
 |
 |
Ocugen
OCGN
|
$ 2.04
|
637 M
|
$ -74.6 M
|
-9.0
|
121.9
|
$ -0.2
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 4.45
|
614 M
|
$ -53.6 M
|
68.3
|
7.9
|
$ 0.1
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 22.32
|
601 M
|
$ -2.42 M
|
-98.9
|
7.7
|
$ -0.2
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 8.93
|
578 M
|
$ -651 M
|
-0.6
|
1.0
|
$ -15.0
|
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.56
|
566 M
|
$ -124 M
|
-5.8
|
12.8
|
$ -0.3
|
 |
 |
Replimune Group
REPL
|
$ 6.98
|
562 M
|
$ -309 M
|
-2.0
|
∙ |
$ -3.4
|
 |
 |
Tenax Therapeutics
TENX
|
$ 14.3
|
561 M
|
$ 1.23 M
|
-13.1
|
1556.5
|
$ -1.1
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 2.55
|
530 M
|
$ -164 M
|
-4.5
|
1.9
|
$ -0.6
|
 |
 |
SELLAS Life Sciences Group
SLS
|
$ 4.76
|
519 M
|
$ -39.5 M
|
-17.3
|
12.0
|
$ -0.3
|
 |
 |
Ironwood Pharmaceuticals
IRWD
|
$ 3.04
|
484 M
|
$ 113 M
|
17.0
|
1.5
|
$ 0.2
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 8.75
|
471 M
|
$ -256 M
|
-1.6
|
43.2
|
$ -5.2
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 25.96
|
467 M
|
$ 119 M
|
4.2
|
1.7
|
$ 6.2
|
 |
 |
Kezar Life Sciences
KZR
|
$ 6.43
|
467 M
|
$ -64.9 M
|
-0.8
|
69.4
|
$ -8.4
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 5.66
|
461 M
|
$ -166 M
|
-3.4
|
3.1
|
$ -1.7
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 2.07
|
457 M
|
$ -295 M
|
-2.2
|
5101.9
|
$ -1.0
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 3.69
|
452 M
|
$ -63.6 M
|
-7.8
|
42.1
|
$ -0.5
|
 |
 |
Benitec Biopharma
BNTC
|
$ 10.98
|
452 M
|
$ -44.1 M
|
-11.7
|
3641.2
|
$ -1.0
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 0.59
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
Shattuck Labs
STTK
|
$ 6.22
|
433 M
|
$ -76.3 M
|
-6.2
|
63.2
|
$ -1.0
|
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 0.88
|
428 M
|
$ -59.3 M
|
4.7
|
9.2
|
$ 0.2
|
 |
 |
Aquestive Therapeutics
AQST
|
$ 3.98
|
426 M
|
$ -30.5 M
|
-9.2
|
7.7
|
$ -0.4
|
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 7.12
|
420 M
|
$ -95.2 M
|
-7.6
|
2.5
|
$ -1.1
|
 |
 |
REGENXBIO
RGNX
|
$ 8.1
|
418 M
|
$ -246 M
|
-1.7
|
4.4
|
$ -4.8
|
 |
 |
Keros Therapeutics
KROS
|
$ 10.96
|
408 M
|
$ 38 M
|
8.5
|
1.7
|
$ 1.3
|
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 7.2
|
407 M
|
$ -160 M
|
-3.4
|
27.2
|
$ -2.2
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 2.98
|
393 M
|
$ -264 M
|
-2.5
|
1.8
|
$ -1.2
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 4.14
|
393 M
|
$ -251 M
|
-1.9
|
∙ |
$ -2.3
|
 |
 |
Verastem
VSTM
|
$ 5.53
|
383 M
|
$ -109 M
|
-1.8
|
15.5
|
$ -3.3
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 4.49
|
373 M
|
$ -63.6 M
|
-2.6
|
∙ |
$ -1.7
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.42
|
365 M
|
$ -3.97 M
|
-7.1
|
1.7
|
$ -0.2
|
 |
 |
SIGA Technologies
SIGA
|
$ 4.94
|
353 M
|
$ 50.6 M
|
12.1
|
3.6
|
$ 0.4
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.37
|
350 M
|
$ -258 M
|
-1.3
|
∙ |
$ -1.0
|
 |
 |
XOMA Corporation
XOMA
|
$ 28.71
|
347 M
|
$ 5.72 M
|
-87.2
|
7.6
|
$ -0.3
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 4.06
|
346 M
|
$ -51.1 M
|
-8.6
|
∙ |
$ -0.5
|
 |
 |
Ovid Therapeutics
OVID
|
$ 2.62
|
341 M
|
$ -43 M
|
-5.6
|
44.6
|
$ -0.4
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.45
|
334 M
|
$ -33.3 M
|
-5.2
|
30.4
|
$ -0.3
|
 |
 |
Cerus Corporation
CERS
|
$ 1.72
|
328 M
|
$ -31.5 M
|
-14.7
|
6.6
|
$ -0.1
|
 |
 |
Assembly Biosciences
ASMB
|
$ 28.46
|
319 M
|
$ -63.1 M
|
-5.8
|
3.4
|
$ -4.7
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 5.0
|
315 M
|
$ -83 M
|
-4.3
|
10.4
|
$ -1.1
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 24.1
|
314 M
|
$ -14.2 M
|
-24.6
|
∙ |
$ -1.0
|
 |
 |
Puma Biotechnology
PBYI
|
$ 6.12
|
306 M
|
$ 45.4 M
|
8.0
|
1.3
|
$ 0.8
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 8.39
|
303 M
|
$ -31.2 M
|
-5.4
|
9647.3
|
$ -1.5
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 4.35
|
301 M
|
$ -260 M
|
-1.3
|
12.6
|
$ -3.5
|
 |
 |
Altimmune
ALT
|
$ 3.34
|
294 M
|
$ -95.3 M
|
-3.2
|
15065.8
|
$ -1.1
|
 |
 |
Kamada Ltd.
KMDA
|
$ 8.5
|
260 M
|
$ 6.96 M
|
66.3
|
4.5
|
$ 0.1
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 4.45
|
236 M
|
$ -79.6 M
|
4.1
|
38.5
|
$ 1.1
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 2.99
|
230 M
|
$ -126 M
|
-2.1
|
25.8
|
$ -1.5
|
 |
 |
Voyager Therapeutics
VYGR
|
$ 3.85
|
226 M
|
$ 95.1 M
|
-2.2
|
4.4
|
$ -1.7
|
 |
 |
C4 Therapeutics
CCCC
|
$ 2.7
|
224 M
|
$ -119 M
|
-1.7
|
5.4
|
$ -1.5
|
 |
 |
Protara Therapeutics
TARA
|
$ 5.21
|
223 M
|
$ -43.3 M
|
-3.7
|
77.0
|
$ -1.4
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 6.76
|
220 M
|
$ -22.5 M
|
-10.3
|
457.2
|
$ -0.7
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 3.44
|
219 M
|
$ -22.2 M
|
-2.9
|
726.8
|
$ -1.3
|
 |
 |
Alector
ALEC
|
$ 2.05
|
211 M
|
$ -178 M
|
-1.4
|
7.0
|
$ -1.5
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 55.21
|
209 M
|
$ -12.1 M
|
-37.1
|
∙ |
$ -1.6
|
 |
 |
Editas Medicine
EDIT
|
$ 2.34
|
208 M
|
$ -242 M
|
-0.9
|
13.2
|
$ -2.6
|
 |
 |
Adagene
ADAG
|
$ 3.63
|
204 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Anika Therapeutics
ANIK
|
$ 13.85
|
203 M
|
$ -6.4 M
|
-5.0
|
1.9
|
$ -2.8
|
 |
 |
Compugen Ltd.
CGEN
|
$ 2.09
|
195 M
|
∙ |
∙ |
24.6
|
∙ |
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 7.32
|
195 M
|
$ -20.6 M
|
-20.1
|
5.4
|
$ -0.4
|
 |
 |
Rezolute
RZLT
|
$ 2.48
|
188 M
|
$ -67 M
|
-2.8
|
∙ |
$ -0.9
|
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 6.63
|
182 M
|
$ -56.6 M
|
-3.9
|
1.3
|
$ -1.7
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 4.28
|
181 M
|
$ -9.29 M
|
-0.4
|
37.0
|
$ -9.6
|
 |
 |
MacroGenics
MGNX
|
$ 2.86
|
181 M
|
$ -145 M
|
-58.0
|
0.8
|
$ -0.0
|
 |
 |
Coherus BioSciences
CHRS
|
$ 1.52
|
178 M
|
$ -181 M
|
1.0
|
5.3
|
$ 1.7
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 2.62
|
171 M
|
$ -166 M
|
-1.3
|
4.3
|
$ -2.0
|
 |
 |
Galectin Therapeutics
GALT
|
$ 2.75
|
171 M
|
$ -36 M
|
-4.8
|
-447.4
|
$ -0.6
|
 |
 |
Immunic
IMUX
|
$ 1.1
|
171 M
|
$ -105 M
|
-1.4
|
∙ |
$ -0.8
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 2.14
|
168 M
|
$ -12.8 M
|
-223.0
|
2.8
|
$ -0.0
|
 |
 |
Forte Biosciences
FBRX
|
$ 23.5
|
150 M
|
$ -30.3 M
|
-3.1
|
8.7
|
$ -7.9
|
 |
 |
vTv Therapeutics
VTVT
|
$ 36.0
|
142 M
|
$ -23.5 M
|
∙ |
28.2
|
∙ |
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 3.49
|
141 M
|
$ -20.7 M
|
4.5
|
36.2
|
$ 0.8
|
 |
 |
Codexis
CDXS
|
$ 1.6
|
139 M
|
$ -63.9 M
|
-1.8
|
3.3
|
$ -0.9
|
 |
 |
Fate Therapeutics
FATE
|
$ 1.1
|
131 M
|
$ -186 M
|
-0.8
|
15.4
|
$ -1.3
|
 |
 |
Heron Therapeutics
HRTX
|
$ 0.78
|
130 M
|
$ -72.5 M
|
-6.3
|
0.9
|
$ -0.1
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 15.0
|
128 M
|
$ -91.1 M
|
-0.5
|
12.7
|
$ -33.0
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.37
|
125 M
|
$ -80.8 M
|
-3.4
|
3.3
|
$ -0.7
|
 |
 |
Cardiff Oncology
CRDF
|
$ 1.8
|
120 M
|
$ -53.4 M
|
-2.2
|
236.2
|
$ -0.8
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.11
|
120 M
|
$ -91.7 M
|
-2.2
|
∙ |
$ -1.0
|
 |
 |
ALX Oncology Holdings
ALXO
|
$ 2.18
|
117 M
|
$ -113 M
|
-1.1
|
32.5
|
$ -2.1
|
 |
 |
Cellectis S.A.
CLLS
|
$ 3.34
|
116 M
|
$ -106 M
|
-1.4
|
7.6
|
$ -2.4
|
 |
 |
Corbus Pharmaceuticals Holdings
CRBP
|
$ 8.6
|
115 M
|
$ -78.4 M
|
-1.5
|
56.4
|
$ -5.9
|
 |
 |
Agenus
AGEN
|
$ 3.71
|
110 M
|
$ -128 M
|
-1.2
|
1.1
|
$ -3.1
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 1.81
|
109 M
|
$ -51 M
|
-2.6
|
∙ |
$ -0.7
|
 |
 |
Seer
SEER
|
$ 1.68
|
107 M
|
$ -96.5 M
|
-1.3
|
7.7
|
$ -1.4
|
 |
 |
ADC Therapeutics SA
ADCT
|
$ 3.86
|
105 M
|
$ -239 M
|
-1.5
|
6.2
|
$ -2.8
|
 |
 |
Nkarta
NKTX
|
$ 2.14
|
105 M
|
$ -116 M
|
-1.5
|
906.7
|
$ -1.4
|
 |
 |
Gossamer Bio
GOSS
|
$ 0.42
|
96 M
|
$ -59.8 M
|
-0.7
|
2.3
|
$ -0.7
|
 |
 |
Champions Oncology
CSBR
|
$ 5.86
|
80 M
|
$ 5.92 M
|
18.8
|
1.4
|
$ 0.3
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 4.0
|
79.3 M
|
$ 448 K
|
-3.0
|
∙ |
$ -1.4
|
 |
 |
Pliant Therapeutics
PLRX
|
$ 1.29
|
79.2 M
|
$ -193 M
|
-0.4
|
10.1
|
$ -3.0
|
 |
 |
PMV Pharmaceuticals
PMVP
|
$ 1.47
|
77.2 M
|
$ -88.4 M
|
-1.0
|
∙ |
$ -1.5
|
 |
 |
MediciNova
MNOV
|
$ 1.56
|
76.5 M
|
$ -13.2 M
|
-5.6
|
52.6
|
$ -0.2
|
 |
 |
Equillium
EQ
|
$ 2.13
|
74 M
|
$ -28.8 M
|
-4.8
|
1.6
|
$ -0.4
|
 |
 |
22nd Century Group
XXII
|
$ 3.57
|
73.9 M
|
$ -11.6 M
|
∙ |
3.7
|
$ -1,774.8
|
 |
 |
XBiotech
XBIT
|
$ 2.39
|
72.9 M
|
$ -34.4 M
|
-3.0
|
8.7
|
$ -0.8
|
 |
 |
Tiziana Life Sciences PLC
TLSA
|
$ 1.21
|
71.5 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
PolyPid Ltd.
PYPD
|
$ 4.16
|
68 M
|
$ -17.9 M
|
0.2
|
∙ |
$ 25.9
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 6.81
|
67.3 M
|
$ -85.3 M
|
-2.9
|
22.2
|
$ -2.5
|
 |
 |
BeyondSpring
BYSI
|
$ 1.6
|
64.5 M
|
$ -71 M
|
∙ |
∙ |
∙ |
 |
 |
Minerva Neurosciences
NERV
|
$ 7.54
|
63.8 M
|
$ -21.1 M
|
4.8
|
0.8
|
$ 1.7
|
 |
 |
Fortress Biotech
FBIO
|
$ 2.99
|
62.1 M
|
$ -87.3 M
|
-5.2
|
1.1
|
$ -0.6
|
 |
 |
Atara Biotherapeutics
ATRA
|
$ 4.91
|
61.6 M
|
$ -27.9 M
|
10.7
|
0.4
|
$ 0.5
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 5.45
|
58.1 M
|
$ -25.5 M
|
-1.2
|
2.2
|
$ -5.0
|
 |
 |
Sangamo Therapeutics
SGMO
|
$ 0.33
|
57.6 M
|
$ -113 M
|
-1.1
|
0.9
|
$ -0.3
|
 |
 |
Annovis Bio
ANVS
|
$ 2.6
|
53.4 M
|
$ -24.4 M
|
-1.4
|
∙ |
$ -2.0
|
 |
 |
Entera Bio Ltd.
ENTX
|
$ 1.11
|
50.9 M
|
$ -8.21 M
|
2.4
|
232.2
|
$ 0.5
|
 |
 |
ImmuCell Corporation
ICCC
|
$ 6.07
|
49.6 M
|
$ 3.86 M
|
55.9
|
1.9
|
$ 0.1
|
 |