 |
Eli Lilly and Company
LLY
|
$ 1 049.6
|
945 B
|
$ 2.37 B
|
76.4
|
18.5
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 239.2
|
576 B
|
$ 9.42 B
|
23.6
|
6.2
|
$ 10.1
|
 |
 |
AbbVie
ABBV
|
$ 223.08
|
395 B
|
$ 15.1 B
|
100.5
|
6.7
|
$ 2.2
|
 |
 |
Merck & Co.
MRK
|
$ 117.24
|
297 B
|
$ 2.86 B
|
16.0
|
4.6
|
$ 7.3
|
 |
 |
Novartis AG
NVS
|
$ 156.8
|
227 B
|
$ 10.7 B
|
26.9
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 376.97
|
202 B
|
$ 12.4 B
|
28.4
|
7.6
|
$ 13.2
|
 |
 |
Gilead Sciences
GILD
|
$ 151.58
|
189 B
|
$ 9.3 B
|
24.9
|
6.5
|
$ 6.1
|
 |
 |
Pfizer
PFE
|
$ 27.06
|
153 B
|
$ 6.66 B
|
11.1
|
2.4
|
$ 2.4
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 60.58
|
123 B
|
$ 11 B
|
18.5
|
2.6
|
$ 3.3
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 471.22
|
122 B
|
$ 4.29 B
|
31.8
|
10.5
|
$ 14.8
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 777.48
|
81.3 B
|
$ 4.1 B
|
16.7
|
5.8
|
$ 46.5
|
 |
 |
Zoetis
ZTS
|
$ 127.04
|
57.7 B
|
$ 487 M
|
20.6
|
6.1
|
$ 6.2
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 320.19
|
40.9 B
|
$ -361 M
|
-164.2
|
16.2
|
$ -2.0
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 34.47
|
39.5 B
|
$ 2.81 B
|
80.2
|
2.3
|
$ 0.4
|
 |
 |
Axon Enterprise
AXON
|
$ 433.0
|
32.8 B
|
$ 89.9 M
|
111.9
|
17.7
|
$ 3.9
|
 |
 |
Biogen
BIIB
|
$ 192.06
|
28.1 B
|
$ 2.03 B
|
15.2
|
2.8
|
$ 12.7
|
 |
 |
argenx SE
ARGX
|
$ 826.55
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Insmed Incorporated
INSM
|
$ 149.45
|
24.5 B
|
$ -1.06 B
|
-23.6
|
63.8
|
$ -6.3
|
 |
 |
Incyte Corporation
INCY
|
$ 109.21
|
22.6 B
|
$ 573 M
|
76.9
|
5.1
|
$ 1.4
|
 |
 |
United Therapeutics Corporation
UTHR
|
$ 471.24
|
21.3 B
|
$ 1.42 B
|
17.3
|
7.0
|
$ 27.2
|
 |
 |
Royalty Pharma plc
RPRX
|
$ 44.24
|
19.8 B
|
$ 1.1 B
|
17.6
|
8.5
|
$ 2.5
|
 |
 |
Legend Biotech Corporation
LEGN
|
$ 17.25
|
18.7 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Zai Lab Limited
ZLAB
|
$ 18.45
|
18.3 B
|
$ -218 M
|
-123.0
|
42.0
|
$ -0.2
|
 |
 |
Revolution Medicines
RVMD
|
$ 96.67
|
16.2 B
|
$ -989 M
|
-19.4
|
695.6
|
$ -5.0
|
 |
 |
Moderna
MRNA
|
$ 41.55
|
16 B
|
$ -2.09 B
|
-8.1
|
5.1
|
$ -5.1
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 139.31
|
14 B
|
$ 124 M
|
45.1
|
5.7
|
$ 3.1
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 72.24
|
13.4 B
|
$ -603 M
|
-23.4
|
57.9
|
$ -3.1
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 14.9
|
12.7 B
|
$ -59 M
|
-298.0
|
122.0
|
$ -0.0
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 84.93
|
12.7 B
|
$ -451 M
|
-54.8
|
13.5
|
$ -1.6
|
 |
 |
Exelixis
EXEL
|
$ 43.69
|
12.7 B
|
$ 363 M
|
18.4
|
5.6
|
$ 2.4
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 57.78
|
11 B
|
$ 790 M
|
17.3
|
3.6
|
$ 3.3
|
 |
 |
Mesoblast Limited
MESO
|
$ 16.76
|
10.9 B
|
∙ |
-2.2
|
1098.2
|
$ -7.6
|
 |
 |
Summit Therapeutics
SMMT
|
$ 14.88
|
10.7 B
|
$ -609 M
|
-12.0
|
5308.8
|
$ -1.2
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 65.76
|
10.4 B
|
$ 276 M
|
77.4
|
8.7
|
$ 0.8
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 485.18
|
10.3 B
|
$ -389 M
|
-31.9
|
14.8
|
$ -15.2
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 80.8
|
10.2 B
|
$ 736 M
|
16.5
|
8.3
|
$ 4.9
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 165.34
|
10.2 B
|
$ 73.8 M
|
-29.4
|
2.5
|
$ -5.6
|
 |
 |
Can-Fite BioPharma Ltd.
CANF
|
$ 4.21
|
9.16 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Pulmatrix
PULM
|
$ 2.48
|
9.06 B
|
$ -13.2 M
|
-2.8
|
947.8
|
$ -0.9
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 182.2
|
8.73 B
|
$ -197 M
|
-40.8
|
16.0
|
$ -4.5
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 63.11
|
8.44 B
|
$ -441 M
|
-16.6
|
28.3
|
$ -3.8
|
 |
 |
Avidity Biosciences
RNA
|
$ 72.87
|
8.13 B
|
$ -586 M
|
-18.1
|
401.9
|
$ -4.0
|
 |
 |
Krystal Biotech
KRYS
|
$ 271.11
|
7.75 B
|
$ 145 M
|
43.3
|
21.2
|
$ 6.3
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 36.92
|
7.01 B
|
$ -373 M
|
-0.0
|
71.3
|
$ -791.5
|
 |
 |
Vaxcyte
PCVX
|
$ 55.61
|
6.78 B
|
$ -581 M
|
-12.0
|
∙ |
$ -4.6
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 103.58
|
6.32 B
|
$ -189 M
|
-33.3
|
38.1
|
$ -3.1
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 14.74
|
6.01 B
|
$ -48.8 M
|
-98.3
|
26.8
|
$ -0.2
|
 |
 |
Akari Therapeutics, Plc
AKTX
|
$ 0.25
|
5.97 B
|
$ -15.1 M
|
-3.0
|
∙ |
$ -0.1
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 79.09
|
5.94 B
|
$ -316 M
|
-22.4
|
148.1
|
$ -3.5
|
 |
 |
Alkermes plc
ALKS
|
$ 34.71
|
5.74 B
|
$ 287 M
|
19.5
|
3.9
|
$ 1.8
|
 |
 |
Praxis Precision Medicines
PRAX
|
$ 319.22
|
5.72 B
|
$ -198 M
|
-25.1
|
3668.9
|
$ -12.7
|
 |
 |
PTC Therapeutics
PTCT
|
$ 74.12
|
5.7 B
|
$ 906 M
|
8.2
|
3.2
|
$ 9.1
|
 |
 |
Longeveron
LGVN
|
$ 0.54
|
5.08 B
|
$ -21.7 M
|
-0.4
|
3162.4
|
$ -1.4
|
 |
 |
Protagonist Therapeutics
PTGX
|
$ 82.34
|
5.07 B
|
$ 120 M
|
-43.3
|
117.2
|
$ -1.9
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 47.7
|
4.76 B
|
$ -216 M
|
-14.9
|
45.3
|
$ -3.2
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 100.2
|
4.76 B
|
$ -6.4 M
|
-151.8
|
10.3
|
$ -0.7
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 14.49
|
4.48 B
|
$ 545 M
|
103.5
|
1.5
|
$ 0.1
|
 |
 |
Amicus Therapeutics
FOLD
|
$ 14.29
|
4.35 B
|
$ 46.2 M
|
-129.9
|
7.4
|
$ -0.1
|
 |
 |
TG Therapeutics
TGTX
|
$ 29.55
|
4.29 B
|
$ -72.3 M
|
10.0
|
8.5
|
$ 2.9
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 41.1
|
4.24 B
|
$ 80.9 M
|
35.4
|
5.7
|
$ 1.2
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 49.37
|
4.16 B
|
$ -601 M
|
-8.0
|
1282.3
|
$ -6.2
|
 |
 |
Immunovant
IMVT
|
$ 27.47
|
4.16 B
|
$ 324 K
|
-9.8
|
∙ |
$ -2.8
|
 |
 |
Inhibrx
INBX
|
$ 86.14
|
4.06 B
|
$ -160 M
|
-20.5
|
9143.6
|
$ -4.2
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 23.1
|
3.83 B
|
$ -213 M
|
-15.9
|
7.7
|
$ -1.4
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 45.75
|
3.7 B
|
$ -274 M
|
-9.9
|
1911.0
|
$ -4.6
|
 |
 |
ADMA Biologics
ADMA
|
$ 16.33
|
3.66 B
|
$ 176 M
|
29.7
|
7.4
|
$ 0.6
|
 |
 |
Denali Therapeutics
DNLI
|
$ 20.89
|
3.44 B
|
$ -471 M
|
-7.3
|
10.3
|
$ -2.9
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 183.65
|
3.36 B
|
$ 60.8 M
|
50.4
|
12.9
|
$ 3.6
|
 |
 |
Spruce Biosciences
SPRB
|
$ 79.94
|
3.3 B
|
$ -51.8 M
|
-2.3
|
452.7
|
$ -34.2
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 42.29
|
3.29 B
|
$ -216 M
|
-11.0
|
194.5
|
$ -3.9
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 26.74
|
3.23 B
|
$ -142 M
|
-24.8
|
14.5
|
$ -1.1
|
 |
 |
Viking Therapeutics
VKTX
|
$ 29.11
|
3.17 B
|
$ -201 M
|
-20.6
|
∙ |
$ -1.4
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 44.16
|
3.15 B
|
$ 24.2 M
|
368.0
|
6.1
|
$ 0.1
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 24.44
|
2.9 B
|
$ 152 M
|
14.4
|
5.1
|
$ 1.7
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 23.0
|
2.85 B
|
$ -471 M
|
-12.6
|
3.8
|
$ -1.8
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 51.11
|
2.82 B
|
$ 4.48 M
|
567.9
|
4.1
|
$ 0.1
|
 |
 |
Liquidia Corporation
LQDA
|
$ 42.23
|
2.74 B
|
$ -99.1 M
|
-30.6
|
38.8
|
$ -1.4
|
 |
 |
Veracyte
VCYT
|
$ 36.7
|
2.67 B
|
$ 48.4 M
|
70.6
|
5.4
|
$ 0.5
|
 |
 |
IDEAYA Biosciences
IDYA
|
$ 32.35
|
2.64 B
|
$ -129 M
|
-34.0
|
11.6
|
$ -1.0
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 65.12
|
2.45 B
|
$ -87.3 M
|
-32.1
|
7.0
|
$ -2.0
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 29.62
|
2.4 B
|
$ -251 M
|
-7.3
|
33.9
|
$ -4.0
|
 |
 |
RAPT Therapeutics
RAPT
|
$ 57.78
|
2.36 B
|
$ -77 M
|
-11.2
|
585.9
|
$ -5.2
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 15.78
|
2.32 B
|
$ -60.1 M
|
-29.8
|
9.2
|
$ -0.5
|
 |
 |
Beam Therapeutics
BEAM
|
$ 27.1
|
2.23 B
|
$ -451 M
|
-6.0
|
55.9
|
$ -4.5
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 22.4
|
2.17 B
|
$ -83 M
|
-18.2
|
488.1
|
$ -1.2
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 23.98
|
2.17 B
|
$ -664 M
|
-4.0
|
6.2
|
$ -6.0
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 36.97
|
2.1 B
|
$ 250 M
|
11.7
|
2.6
|
$ 3.2
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 14.48
|
2.07 B
|
$ 60.9 M
|
28.4
|
7.7
|
$ 0.5
|
 |
 |
Dynavax Technologies Corporation
DVAX
|
$ 15.5
|
2.02 B
|
$ -3.96 M
|
-62.0
|
5.9
|
$ -0.2
|
 |
 |
Arcus Biosciences
RCUS
|
$ 20.97
|
1.89 B
|
$ -281 M
|
-6.5
|
6.9
|
$ -3.2
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 13.63
|
1.88 B
|
$ -145 M
|
-9.8
|
37.6
|
$ -1.4
|
 |
 |
Seres Therapeutics
MCRB
|
$ 14.5
|
1.86 B
|
$ -99.2 M
|
1.0
|
14.7
|
$ 14.1
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 21.12
|
1.81 B
|
$ -130 M
|
-6.0
|
15.5
|
$ -3.5
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 9.44
|
1.77 B
|
$ -136 M
|
-6.9
|
32.7
|
$ -1.4
|
 |
 |
Vericel Corporation
VCEL
|
$ 35.45
|
1.73 B
|
$ -4.45 M
|
-221.6
|
7.2
|
$ -0.2
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 62.09
|
1.73 B
|
$ -28.2 M
|
48.5
|
174.7
|
$ 1.3
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 18.17
|
1.73 B
|
$ -254 M
|
-4.5
|
0.8
|
$ -4.0
|
 |
 |
Ardelyx
ARDX
|
$ 7.32
|
1.72 B
|
$ -107 M
|
-17.0
|
5.0
|
$ -0.4
|
 |
 |
MannKind Corporation
MNKD
|
$ 5.9
|
1.62 B
|
$ 67.5 M
|
59.0
|
5.3
|
$ 0.1
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 80.39
|
1.55 B
|
$ 140 M
|
81.2
|
2.0
|
$ 1.0
|
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 26.79
|
1.52 B
|
$ -381 M
|
2.3
|
39.3
|
$ 11.5
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 46.2
|
1.48 B
|
$ 158 M
|
26.4
|
2.0
|
$ 1.8
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 16.65
|
1.44 B
|
$ -190 M
|
-5.8
|
17.4
|
$ -2.9
|
 |
 |
AnaptysBio
ANAB
|
$ 49.85
|
1.41 B
|
$ -143 M
|
-15.5
|
9.0
|
$ -3.2
|
 |
 |
Burford Capital Limited
BUR
|
$ 8.96
|
1.41 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Stoke Therapeutics
STOK
|
$ 31.95
|
1.41 B
|
$ 33.6 M
|
74.3
|
7.5
|
$ 0.4
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 28.66
|
1.39 B
|
$ 211 M
|
11.9
|
1.9
|
$ 2.4
|
 |
 |
Innoviva
INVA
|
$ 21.58
|
1.35 B
|
$ 194 M
|
13.6
|
3.5
|
$ 1.6
|
 |
 |
Novavax
NVAX
|
$ 8.67
|
1.32 B
|
$ -17.9 M
|
4.6
|
1.2
|
$ 1.9
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 6.26
|
1.29 B
|
$ -37 M
|
-125.2
|
2.2
|
$ -0.0
|
 |
 |
Kodiak Sciences
KOD
|
$ 24.24
|
1.27 B
|
$ -244 M
|
-5.9
|
∙ |
$ -4.1
|
 |
 |
uniQure N.V.
QURE
|
$ 25.93
|
1.26 B
|
$ -211 M
|
-6.8
|
98.4
|
$ -3.8
|
 |
 |
Relay Therapeutics
RLAY
|
$ 8.62
|
1.23 B
|
$ -356 M
|
-4.5
|
28.3
|
$ -1.9
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 12.32
|
1.22 B
|
$ -477 M
|
-2.8
|
22.6
|
$ -4.3
|
 |
 |
Zymeworks
ZYME
|
$ 22.41
|
1.16 B
|
$ -268 M
|
-4.8
|
132.4
|
$ -4.6
|
 |
 |
Certara
CERT
|
$ 7.18
|
1.15 B
|
$ 65.2 M
|
359.0
|
2.8
|
$ 0.0
|
 |
 |
Taysha Gene Therapies
TSHA
|
$ 4.54
|
1.14 B
|
$ -107 M
|
-12.6
|
158.0
|
$ -0.4
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 24.98
|
1.13 B
|
$ -121 M
|
-12.7
|
∙ |
$ -2.0
|
 |
 |
Precigen
PGEN
|
$ 4.55
|
1.11 B
|
$ 14.9 M
|
-3.2
|
47.8
|
$ -1.4
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 11.1
|
1.1 B
|
$ -39.2 M
|
-28.5
|
∙ |
$ -0.4
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 6.96
|
1.02 B
|
$ 3.68 M
|
-24.9
|
3.9
|
$ -0.3
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 20.33
|
976 M
|
$ -37.9 M
|
-33.3
|
∙ |
$ -0.6
|
 |
 |
Vir Biotechnology
VIR
|
$ 7.21
|
967 M
|
$ -669 M
|
-1.6
|
140.0
|
$ -4.6
|
 |
 |
Arvinas
ARVN
|
$ 13.32
|
958 M
|
$ -101 M
|
-15.5
|
2.7
|
$ -0.9
|
 |
 |
Theravance Biopharma
TBPH
|
$ 19.47
|
951 M
|
$ -131 M
|
34.8
|
12.3
|
$ 0.6
|
 |
 |
AbCellera Biologics
ABCL
|
$ 3.19
|
939 M
|
$ -229 M
|
-5.1
|
25.5
|
$ -0.6
|
 |
 |
Geron Corporation
GERN
|
$ 1.61
|
919 M
|
$ -152 M
|
-13.4
|
5.6
|
$ -0.1
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 3.17
|
908 M
|
$ -24.3 M
|
-24.4
|
∙ |
$ -0.1
|
 |
 |
Sutro Biopharma
STRO
|
$ 14.38
|
865 M
|
$ -179 M
|
-6.2
|
8.7
|
$ -2.3
|
 |
 |
Savara
SVRA
|
$ 5.22
|
862 M
|
$ -116 M
|
-10.2
|
1084.7
|
$ -0.5
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 12.77
|
826 M
|
$ -651 M
|
-0.8
|
1.4
|
$ -15.0
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 12.79
|
808 M
|
$ -296 M
|
-2.4
|
8.8
|
$ -5.2
|
 |
 |
Sana Biotechnology
SANA
|
$ 3.99
|
776 M
|
$ -237 M
|
-4.0
|
∙ |
$ -1.0
|
 |
 |
Xencor
XNCR
|
$ 11.89
|
773 M
|
$ -169 M
|
-6.4
|
6.7
|
$ -1.9
|
 |
 |
Annexon
ANNX
|
$ 5.62
|
772 M
|
$ -180 M
|
-4.7
|
∙ |
$ -1.2
|
 |
 |
Ironwood Pharmaceuticals
IRWD
|
$ 4.84
|
770 M
|
$ 113 M
|
25.5
|
2.3
|
$ 0.2
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 10.6
|
739 M
|
$ -112 M
|
-6.2
|
∙ |
$ -1.7
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 14.76
|
733 M
|
$ -159 M
|
-3.9
|
16.7
|
$ -3.8
|
 |
 |
Cullinan Management
CGEM
|
$ 11.72
|
686 M
|
$ -190 M
|
-3.6
|
36.2
|
$ -3.2
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 25.04
|
671 M
|
$ -90.2 M
|
-12.4
|
38.7
|
$ -2.0
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.01
|
666 M
|
$ -78.1 M
|
-15.4
|
46.3
|
$ -0.3
|
 |
 |
Kura Oncology
KURA
|
$ 7.69
|
663 M
|
$ -118 M
|
-2.7
|
13.2
|
$ -2.9
|
 |
 |
Omeros Corporation
OMER
|
$ 11.3
|
657 M
|
$ -128 M
|
-5.5
|
7.3
|
$ -2.0
|
 |
 |
Keros Therapeutics
KROS
|
$ 17.49
|
655 M
|
$ 38 M
|
13.4
|
2.7
|
$ 1.3
|
 |
 |
Galecto
GLTO
|
$ 24.05
|
639 M
|
$ -13 M
|
-2.3
|
∙ |
$ -10.3
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 3.56
|
633 M
|
$ -9.29 M
|
-0.4
|
132.7
|
$ -9.6
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 21.94
|
633 M
|
$ -112 M
|
-7.2
|
6.4
|
$ -3.1
|
 |
 |
Replimune Group
REPL
|
$ 7.75
|
624 M
|
$ -309 M
|
-2.3
|
∙ |
$ -3.4
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 9.45
|
622 M
|
$ 16.5 M
|
78.8
|
5.9
|
$ 0.1
|
 |
 |
Atossa Therapeutics
ATOS
|
$ 4.91
|
619 M
|
$ -29.7 M
|
-19.6
|
5429.3
|
$ -0.2
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 3.29
|
616 M
|
$ -164 M
|
-5.7
|
2.2
|
$ -0.6
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 34.26
|
602 M
|
$ 119 M
|
5.5
|
2.2
|
$ 6.2
|
 |
 |
Passage Bio
PASG
|
$ 9.3
|
562 M
|
$ -54.7 M
|
-0.8
|
∙ |
$ -11.8
|
 |
 |
Immunome
IMNM
|
$ 24.38
|
484 M
|
$ -154 M
|
-9.6
|
46.9
|
$ -2.5
|
 |
 |
Benitec Biopharma
BNTC
|
$ 11.75
|
484 M
|
$ -34.3 M
|
-12.1
|
3720.3
|
$ -1.0
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 5.65
|
477 M
|
$ -53.6 M
|
80.7
|
5.7
|
$ 0.1
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 8.85
|
476 M
|
$ -256 M
|
-1.7
|
44.8
|
$ -5.2
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 7.33
|
471 M
|
$ -85.3 M
|
-2.9
|
144.2
|
$ -2.5
|
 |
 |
SIGA Technologies
SIGA
|
$ 6.58
|
470 M
|
$ 50.6 M
|
15.7
|
4.7
|
$ 0.4
|
 |
 |
REGENXBIO
RGNX
|
$ 10.29
|
450 M
|
$ -246 M
|
-2.1
|
4.6
|
$ -4.8
|
 |
 |
Kezar Life Sciences
KZR
|
$ 6.15
|
446 M
|
$ -64.9 M
|
-0.7
|
63.7
|
$ -8.4
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 0.98
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 7.5
|
436 M
|
$ -95.2 M
|
-6.6
|
2.2
|
$ -1.1
|
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 7.61
|
430 M
|
$ -160 M
|
-3.5
|
28.1
|
$ -2.2
|
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 1.06
|
428 M
|
$ -59.3 M
|
5.6
|
9.2
|
$ 0.2
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 3.13
|
413 M
|
$ -264 M
|
-2.6
|
1.8
|
$ -1.2
|
 |
 |
Ocugen
OCGN
|
$ 1.39
|
405 M
|
$ -74.6 M
|
-5.6
|
70.5
|
$ -0.2
|
 |
 |
Cerus Corporation
CERS
|
$ 2.17
|
401 M
|
$ -31.5 M
|
-18.1
|
7.8
|
$ -0.1
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 29.93
|
390 M
|
$ -14.2 M
|
-28.5
|
∙ |
$ -1.0
|
 |
 |
CorMedix
CRMD
|
$ 7.59
|
386 M
|
$ 47.5 M
|
3.8
|
2.0
|
$ 2.0
|
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.2
|
384 M
|
$ -124 M
|
-4.3
|
8.3
|
$ -0.3
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 14.81
|
380 M
|
$ -2.42 M
|
-70.5
|
5.5
|
$ -0.2
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 4.37
|
373 M
|
$ -51.1 M
|
-8.9
|
∙ |
$ -0.5
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.46
|
373 M
|
$ -258 M
|
-1.4
|
6.1
|
$ -1.0
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 4.13
|
348 M
|
$ -166 M
|
-2.4
|
2.2
|
$ -1.7
|
 |
 |
Gossamer Bio
GOSS
|
$ 2.26
|
345 M
|
$ -59.8 M
|
-3.3
|
7.8
|
$ -0.7
|
 |
 |
Generation Bio Co.
GBIO
|
$ 5.34
|
344 M
|
$ -59.2 M
|
-0.8
|
18.5
|
$ -6.4
|
 |
 |
Aquestive Therapeutics
AQST
|
$ 3.93
|
341 M
|
$ -30.5 M
|
-8.9
|
6.0
|
$ -0.4
|
 |
 |
Altimmune
ALT
|
$ 4.76
|
338 M
|
$ -95.3 M
|
-4.5
|
16898.8
|
$ -1.1
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 5.28
|
337 M
|
$ -24.4 M
|
-4.2
|
1048.5
|
$ -1.3
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 5.75
|
335 M
|
$ -260 M
|
-1.6
|
13.4
|
$ -3.5
|
 |
 |
Puma Biotechnology
PBYI
|
$ 6.84
|
333 M
|
$ 45.4 M
|
8.9
|
1.4
|
$ 0.8
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 5.53
|
329 M
|
$ -51 M
|
-7.8
|
∙ |
$ -0.7
|
 |
 |
NextCure
NXTC
|
$ 11.65
|
326 M
|
$ -76.6 M
|
-0.6
|
4.7
|
$ -19.8
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 6.94
|
315 M
|
$ -25.5 M
|
-1.4
|
11.0
|
$ -5.0
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 3.2
|
303 M
|
$ -251 M
|
-1.4
|
∙ |
$ -2.3
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 5.47
|
300 M
|
$ -83 M
|
-4.8
|
10.2
|
$ -1.1
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.67
|
288 M
|
$ -33.3 M
|
-5.6
|
24.6
|
$ -0.3
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 3.69
|
285 M
|
$ -63.6 M
|
-7.7
|
26.2
|
$ -0.5
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 7.77
|
280 M
|
$ -31.2 M
|
-5.1
|
9042.2
|
$ -1.5
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.49
|
279 M
|
$ -3.97 M
|
-7.4
|
1.3
|
$ -0.2
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 16.28
|
277 M
|
$ -91.1 M
|
-0.5
|
26.3
|
$ -33.0
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 8.22
|
268 M
|
$ -22.5 M
|
-12.1
|
535.4
|
$ -0.7
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 1.68
|
264 M
|
$ -295 M
|
-1.6
|
2746.3
|
$ -1.0
|
 |
 |
Kamada Ltd.
KMDA
|
$ 8.29
|
260 M
|
$ 6.96 M
|
63.8
|
4.5
|
$ 0.1
|
 |
 |
BiomX
PHGE
|
$ 4.77
|
245 M
|
$ -26.2 M
|
9.5
|
∙ |
$ 0.5
|
 |
 |
Rezolute
RZLT
|
$ 3.1
|
236 M
|
$ -67 M
|
-3.5
|
∙ |
$ -0.9
|
 |
 |
Sensei Biotherapeutics
SNSE
|
$ 8.86
|
223 M
|
$ -31.2 M
|
-0.6
|
∙ |
$ -13.6
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 56.83
|
215 M
|
$ -12.1 M
|
-36.0
|
∙ |
$ -1.6
|
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 7.84
|
208 M
|
$ -20.6 M
|
-20.6
|
5.5
|
$ -0.4
|
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 7.47
|
202 M
|
$ -56.6 M
|
-4.3
|
1.5
|
$ -1.7
|
 |
 |
Coherus BioSciences
CHRS
|
$ 2.07
|
195 M
|
$ -181 M
|
1.2
|
5.5
|
$ 1.7
|
 |
 |
Heron Therapeutics
HRTX
|
$ 1.27
|
194 M
|
$ -72.5 M
|
-9.8
|
1.3
|
$ -0.1
|
 |
 |
Alector
ALEC
|
$ 1.98
|
191 M
|
$ -178 M
|
-1.3
|
6.3
|
$ -1.5
|
 |
 |
Forte Biosciences
FBRX
|
$ 29.78
|
190 M
|
$ -30.3 M
|
-3.8
|
10.6
|
$ -7.9
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 2.8
|
189 M
|
$ -12.8 M
|
-280.0
|
3.1
|
$ -0.0
|
 |
 |
Galectin Therapeutics
GALT
|
$ 2.73
|
170 M
|
$ -36 M
|
-4.7
|
-436.2
|
$ -0.6
|
 |
 |
Shattuck Labs
STTK
|
$ 3.98
|
170 M
|
$ -76.3 M
|
-4.1
|
25.2
|
$ -1.0
|
 |
 |
Voyager Therapeutics
VYGR
|
$ 3.72
|
160 M
|
$ 95.1 M
|
-2.2
|
3.2
|
$ -1.7
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 2.4
|
157 M
|
$ -166 M
|
-1.2
|
4.0
|
$ -2.0
|
 |
 |
Compugen Ltd.
CGEN
|
$ 1.72
|
154 M
|
∙ |
∙ |
19.2
|
∙ |
 |
 |
Anika Therapeutics
ANIK
|
$ 10.24
|
150 M
|
$ -6.4 M
|
-3.6
|
1.3
|
$ -2.8
|
 |
 |
Editas Medicine
EDIT
|
$ 1.81
|
149 M
|
$ -242 M
|
-0.7
|
9.4
|
$ -2.6
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 3.39
|
149 M
|
$ -63.6 M
|
-2.0
|
∙ |
$ -1.7
|
 |
 |
Adagene
ADAG
|
$ 2.6
|
146 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Verastem
VSTM
|
$ 6.61
|
146 M
|
$ -109 M
|
-2.0
|
5.6
|
$ -3.3
|
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 3.43
|
138 M
|
$ -20.7 M
|
4.2
|
34.4
|
$ 0.8
|
 |
 |
Protara Therapeutics
TARA
|
$ 6.46
|
133 M
|
$ -43.3 M
|
-4.5
|
45.1
|
$ -1.4
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 2.13
|
129 M
|
$ -126 M
|
-1.4
|
13.5
|
$ -1.5
|
 |
 |
vTv Therapeutics
VTVT
|
$ 32.33
|
128 M
|
$ -23.5 M
|
∙ |
25.5
|
∙ |
 |
 |
Fate Therapeutics
FATE
|
$ 1.12
|
127 M
|
$ -186 M
|
-0.9
|
15.2
|
$ -1.3
|
 |
 |
CASI Pharmaceuticals
CASI
|
$ 0.93
|
127 M
|
$ -27.1 M
|
-0.5
|
3.5
|
$ -1.7
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.37
|
125 M
|
$ -80.8 M
|
-3.2
|
3.2
|
$ -0.7
|
 |
 |
C4 Therapeutics
CCCC
|
$ 1.8
|
125 M
|
$ -119 M
|
-1.2
|
3.1
|
$ -1.5
|
 |
 |
ALX Oncology Holdings
ALXO
|
$ 2.38
|
124 M
|
$ -113 M
|
-1.2
|
34.3
|
$ -2.1
|
 |
 |
Assembly Biosciences
ASMB
|
$ 27.11
|
124 M
|
$ -63.1 M
|
-5.7
|
3.4
|
$ -4.7
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.24
|
123 M
|
$ -91.7 M
|
-2.3
|
∙ |
$ -1.0
|
 |
 |
Cellectis S.A.
CLLS
|
$ 3.72
|
116 M
|
$ -106 M
|
-1.5
|
7.6
|
$ -2.4
|
 |
 |
Seer
SEER
|
$ 1.81
|
116 M
|
$ -96.5 M
|
-1.3
|
8.1
|
$ -1.4
|
 |
 |
22nd Century Group
XXII
|
$ 5.49
|
114 M
|
$ -11.6 M
|
∙ |
5.7
|
$ -1,774.8
|
 |
 |
MacroGenics
MGNX
|
$ 1.81
|
112 M
|
$ -145 M
|
-36.2
|
0.5
|
$ -0.0
|
 |
 |
Ovid Therapeutics
OVID
|
$ 1.58
|
112 M
|
$ -43 M
|
-3.8
|
16.6
|
$ -0.4
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 5.15
|
110 M
|
$ -79.6 M
|
4.7
|
17.6
|
$ 1.1
|
 |
 |
ADC Therapeutics SA
ADCT
|
$ 3.97
|
105 M
|
$ -239 M
|
-1.4
|
6.2
|
$ -2.8
|
 |
 |
SELLAS Life Sciences Group
SLS
|
$ 3.75
|
104 M
|
$ -39.5 M
|
-12.5
|
8.7
|
$ -0.3
|
 |
 |
Nkarta
NKTX
|
$ 2.0
|
98 M
|
$ -116 M
|
-1.4
|
835.6
|
$ -1.4
|
 |
 |
Cassava Sciences
SAVA
|
$ 2.05
|
95 M
|
$ -112 M
|
-0.9
|
2.3
|
$ -2.2
|
 |
 |
Codexis
CDXS
|
$ 1.29
|
94.7 M
|
$ -63.9 M
|
-1.4
|
2.1
|
$ -0.9
|
 |
 |
Champions Oncology
CSBR
|
$ 6.56
|
89.6 M
|
$ 1.27 M
|
-218.7
|
1.7
|
$ -0.0
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 4.32
|
85.7 M
|
$ 448 K
|
-3.1
|
∙ |
$ -1.4
|
 |
 |
MediciNova
MNOV
|
$ 1.65
|
80.9 M
|
$ -13.2 M
|
-6.6
|
62.5
|
$ -0.2
|
 |
 |
Cardiff Oncology
CRDF
|
$ 1.61
|
76.7 M
|
$ -53.4 M
|
-1.9
|
149.0
|
$ -0.8
|
 |
 |
Fortress Biotech
FBIO
|
$ 3.67
|
76.3 M
|
$ -87.3 M
|
-6.0
|
1.2
|
$ -0.6
|
 |
 |
Lyra Therapeutics
LYRA
|
$ 1.51
|
75.2 M
|
$ -72.2 M
|
-0.1
|
128.3
|
$ -18.1
|
 |
 |
XBiotech
XBIT
|
$ 2.35
|
71.5 M
|
$ -34.4 M
|
-3.0
|
8.7
|
$ -0.8
|
 |
 |
Tiziana Life Sciences PLC
TLSA
|
$ 1.45
|
71.5 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Pliant Therapeutics
PLRX
|
$ 1.16
|
70.2 M
|
$ -193 M
|
-0.4
|
8.7
|
$ -3.0
|
 |
 |
Immunic
IMUX
|
$ 0.7
|
70.1 M
|
$ -105 M
|
-0.8
|
∙ |
$ -0.8
|
 |
 |
Sangamo Therapeutics
SGMO
|
$ 0.4
|
69.8 M
|
$ -113 M
|
-1.2
|
1.0
|
$ -0.3
|
 |
 |
Milestone Pharmaceuticals
MIST
|
$ 1.83
|
61.3 M
|
$ -61.4 M
|
-2.4
|
∙ |
$ -0.8
|
 |