 |
Eli Lilly and Company
LLY
|
$ 963.33
|
864 B
|
$ 2.37 B
|
68.0
|
16.4
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 227.19
|
547 B
|
$ 9.42 B
|
20.6
|
5.9
|
$ 11.2
|
 |
 |
AbbVie
ABBV
|
$ 206.6
|
365 B
|
$ 15.1 B
|
95.2
|
6.3
|
$ 2.2
|
 |
 |
Akari Therapeutics, Plc
AKTX
|
$ 5.41
|
364 B
|
$ -15.1 M
|
-65.1
|
∙ |
$ -0.1
|
 |
 |
Merck & Co.
MRK
|
$ 112.16
|
281 B
|
$ 2.86 B
|
14.9
|
4.2
|
$ 7.3
|
 |
 |
Novartis AG
NVS
|
$ 146.57
|
227 B
|
$ 10.7 B
|
25.4
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 329.82
|
177 B
|
$ 12.4 B
|
26.1
|
7.0
|
$ 13.2
|
 |
 |
Gilead Sciences
GILD
|
$ 131.65
|
164 B
|
$ 9.3 B
|
21.5
|
5.6
|
$ 6.1
|
 |
 |
Pfizer
PFE
|
$ 26.33
|
150 B
|
$ 6.66 B
|
10.9
|
2.4
|
$ 2.4
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 58.22
|
118 B
|
$ 11 B
|
18.5
|
2.6
|
$ 3.3
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 423.92
|
108 B
|
$ 4.29 B
|
28.8
|
9.4
|
$ 14.8
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 701.42
|
73.4 B
|
$ 3.4 B
|
17.6
|
5.3
|
$ 40.2
|
 |
 |
Zoetis
ZTS
|
$ 114.16
|
50.6 B
|
$ 487 M
|
18.7
|
5.4
|
$ 6.2
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 34.95
|
40 B
|
$ 3.49 B
|
30.8
|
2.4
|
$ 1.1
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 296.11
|
38.8 B
|
$ -361 M
|
-158.7
|
16.0
|
$ -2.0
|
 |
 |
Axon Enterprise
AXON
|
$ 402.31
|
30.5 B
|
$ 89.9 M
|
103.8
|
16.4
|
$ 3.9
|
 |
 |
Biogen
BIIB
|
$ 187.06
|
27.4 B
|
$ 2.03 B
|
17.5
|
2.8
|
$ 10.8
|
 |
 |
Insmed Incorporated
INSM
|
$ 133.26
|
26.5 B
|
$ -1.06 B
|
-21.5
|
70.6
|
$ -6.3
|
 |
 |
Revolution Medicines
RVMD
|
$ 139.48
|
26.5 B
|
$ -989 M
|
-28.9
|
1175.5
|
$ -5.0
|
 |
 |
United Therapeutics Corporation
UTHR
|
$ 570.4
|
25.3 B
|
$ 1.42 B
|
21.0
|
8.3
|
$ 27.2
|
 |
 |
argenx SE
ARGX
|
$ 783.5
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Zai Lab Limited
ZLAB
|
$ 21.54
|
23.6 B
|
$ -218 M
|
-144.3
|
54.5
|
$ -0.2
|
 |
 |
Royalty Pharma plc
RPRX
|
$ 49.47
|
21.3 B
|
$ 1.1 B
|
20.0
|
9.3
|
$ 2.5
|
 |
 |
Incyte Corporation
INCY
|
$ 96.91
|
18.9 B
|
$ 710 M
|
19.1
|
4.0
|
$ 5.0
|
 |
 |
Legend Biotech Corporation
LEGN
|
$ 23.59
|
18.7 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Moderna
MRNA
|
$ 45.37
|
17.6 B
|
$ -2.09 B
|
-9.0
|
5.7
|
$ -5.1
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 86.46
|
16.4 B
|
$ -373 M
|
-0.1
|
164.2
|
$ -791.5
|
 |
 |
Longeveron
LGVN
|
$ 0.85
|
14.9 B
|
$ -21.7 M
|
-0.6
|
9296.9
|
$ -1.4
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 68.56
|
13.1 B
|
$ -603 M
|
-23.1
|
58.7
|
$ -3.1
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 131.78
|
13.1 B
|
$ 124 M
|
42.6
|
5.3
|
$ 3.1
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 202.72
|
12.4 B
|
$ 73.8 M
|
-36.1
|
3.0
|
$ -5.6
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 75.28
|
12 B
|
$ -517 M
|
-45.0
|
12.4
|
$ -1.7
|
 |
 |
Summit Therapeutics
SMMT
|
$ 16.11
|
12 B
|
$ -609 M
|
-15.3
|
7967.1
|
$ -1.4
|
 |
 |
Exelixis
EXEL
|
$ 43.68
|
11.9 B
|
$ 363 M
|
18.7
|
5.3
|
$ 2.4
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 513.72
|
11.5 B
|
$ -389 M
|
-34.0
|
16.6
|
$ -15.2
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 13.3
|
11.4 B
|
$ -59 M
|
-268.8
|
110.4
|
$ -0.0
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 54.06
|
10.4 B
|
$ 790 M
|
16.1
|
3.4
|
$ 3.3
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 206.53
|
10.3 B
|
$ -197 M
|
-46.5
|
18.9
|
$ -4.5
|
 |
 |
Mesoblast Limited
MESO
|
$ 15.74
|
10.2 B
|
∙ |
-2.1
|
1026.8
|
$ -7.6
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 74.81
|
10 B
|
$ -441 M
|
-19.3
|
33.0
|
$ -3.8
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 55.02
|
8.67 B
|
$ 276 M
|
65.1
|
7.3
|
$ 0.8
|
 |
 |
Vaxcyte
PCVX
|
$ 56.93
|
7.75 B
|
$ -581 M
|
-12.3
|
∙ |
$ -4.6
|
 |
 |
Krystal Biotech
KRYS
|
$ 266.34
|
7.71 B
|
$ 145 M
|
41.9
|
20.8
|
$ 6.3
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 63.96
|
7.66 B
|
$ 736 M
|
13.0
|
6.2
|
$ 4.9
|
 |
 |
Praxis Precision Medicines
PRAX
|
$ 324.2
|
7.3 B
|
$ -198 M
|
-25.1
|
4605.4
|
$ -12.7
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 80.71
|
6.82 B
|
$ -316 M
|
-23.0
|
170.9
|
$ -3.5
|
 |
 |
Protagonist Therapeutics
PTGX
|
$ 98.37
|
6.25 B
|
$ 120 M
|
-52.1
|
145.5
|
$ -1.9
|
 |
 |
Inhibrx
INBX
|
$ 128.79
|
6.07 B
|
$ -160 M
|
-30.8
|
13715.5
|
$ -4.2
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 14.07
|
5.84 B
|
$ -56.2 M
|
-87.1
|
28.6
|
$ -0.2
|
 |
 |
Alkermes plc
ALKS
|
$ 33.38
|
5.5 B
|
$ 287 M
|
18.9
|
3.8
|
$ 1.8
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 51.42
|
5.34 B
|
$ -480 K
|
113.5
|
6.7
|
$ 0.4
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 46.37
|
5.32 B
|
$ -216 M
|
-14.5
|
50.9
|
$ -3.2
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 81.81
|
5.32 B
|
$ -189 M
|
-26.2
|
31.9
|
$ -3.1
|
 |
 |
PTC Therapeutics
PTCT
|
$ 65.15
|
5.18 B
|
$ 906 M
|
7.2
|
2.9
|
$ 9.1
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 40.96
|
5.17 B
|
$ -471 M
|
-22.4
|
7.0
|
$ -1.8
|
 |
 |
TG Therapeutics
TGTX
|
$ 33.83
|
4.88 B
|
$ -72.3 M
|
11.5
|
9.6
|
$ 2.9
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 96.53
|
4.85 B
|
$ -6.4 M
|
-147.4
|
10.6
|
$ -0.7
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 51.63
|
4.64 B
|
$ -601 M
|
-8.5
|
1449.1
|
$ -6.2
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 56.13
|
4.37 B
|
$ -216 M
|
-14.5
|
257.8
|
$ -3.9
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 227.44
|
4.16 B
|
$ 60.8 M
|
63.0
|
16.1
|
$ 3.6
|
 |
 |
Immunovant
IMVT
|
$ 27.12
|
4.11 B
|
$ 324 K
|
-9.7
|
∙ |
$ -2.8
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 55.27
|
4.1 B
|
$ 54 M
|
112.0
|
6.4
|
$ 0.5
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 12.83
|
4.02 B
|
$ 545 M
|
91.9
|
1.4
|
$ 0.1
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 39.02
|
3.67 B
|
$ -274 M
|
-8.4
|
1886.0
|
$ -4.6
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 21.95
|
3.64 B
|
$ -213 M
|
-15.5
|
7.4
|
$ -1.4
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 28.74
|
3.51 B
|
$ 152 M
|
16.6
|
6.1
|
$ 1.7
|
 |
 |
Viking Therapeutics
VKTX
|
$ 30.0
|
3.38 B
|
$ -201 M
|
-22.1
|
∙ |
$ -1.4
|
 |
 |
Liquidia Corporation
LQDA
|
$ 38.14
|
3.28 B
|
$ -99.1 M
|
-28.4
|
47.7
|
$ -1.4
|
 |
 |
Beam Therapeutics
BEAM
|
$ 30.7
|
3.04 B
|
$ -451 M
|
-6.7
|
75.2
|
$ -4.5
|
 |
 |
Denali Therapeutics
DNLI
|
$ 18.3
|
3.01 B
|
$ -471 M
|
-6.5
|
9.2
|
$ -2.9
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 23.35
|
2.97 B
|
$ -142 M
|
-21.5
|
13.2
|
$ -1.1
|
 |
 |
Cue Biopharma
CUE
|
$ 30.42
|
2.88 B
|
$ -35.1 M
|
-27.8
|
125.8
|
$ -0.5
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 19.87
|
2.77 B
|
$ -83 M
|
-21.0
|
691.8
|
$ -1.0
|
 |
 |
Arcus Biosciences
RCUS
|
$ 25.68
|
2.76 B
|
$ -281 M
|
-7.9
|
10.0
|
$ -3.2
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 47.85
|
2.7 B
|
$ 4.48 M
|
533.3
|
4.0
|
$ 0.1
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 63.62
|
2.66 B
|
$ -87.3 M
|
-31.3
|
7.6
|
$ -2.0
|
 |
 |
Veracyte
VCYT
|
$ 33.09
|
2.6 B
|
$ 48.4 M
|
63.3
|
5.2
|
$ 0.5
|
 |
 |
ADMA Biologics
ADMA
|
$ 10.52
|
2.51 B
|
$ 176 M
|
18.6
|
5.0
|
$ 0.6
|
 |
 |
IDEAYA Biosciences
IDYA
|
$ 28.19
|
2.49 B
|
$ -129 M
|
-30.6
|
11.3
|
$ -1.0
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 24.77
|
2.44 B
|
$ -664 M
|
-4.2
|
7.0
|
$ -6.0
|
 |
 |
Kodiak Sciences
KOD
|
$ 43.96
|
2.34 B
|
$ -244 M
|
-10.6
|
∙ |
$ -4.1
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 14.27
|
2.17 B
|
$ -60.1 M
|
-26.6
|
8.5
|
$ -0.5
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 21.49
|
2.15 B
|
$ -254 M
|
-5.2
|
0.9
|
$ -4.0
|
 |
 |
Celldex Therapeutics
CLDX
|
$ 32.31
|
2.15 B
|
$ -159 M
|
-9.9
|
307.0
|
$ -3.3
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 15.35
|
2.06 B
|
$ 60.9 M
|
30.2
|
7.7
|
$ 0.5
|
 |
 |
Taysha Gene Therapies
TSHA
|
$ 6.33
|
2.02 B
|
$ -107 M
|
-17.8
|
284.2
|
$ -0.4
|
 |
 |
Immunome
IMNM
|
$ 22.73
|
1.99 B
|
$ -154 M
|
-9.1
|
194.2
|
$ -2.5
|
 |
 |
Stoke Therapeutics
STOK
|
$ 33.08
|
1.96 B
|
$ 33.6 M
|
76.1
|
10.3
|
$ 0.4
|
 |
 |
AnaptysBio
ANAB
|
$ 66.76
|
1.92 B
|
$ -143 M
|
-20.4
|
12.1
|
$ -3.2
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 9.19
|
1.9 B
|
$ -37 M
|
-183.2
|
3.2
|
$ -0.0
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 13.87
|
1.87 B
|
$ -39.2 M
|
-35.3
|
∙ |
$ -0.4
|
 |
 |
Avidity Biosciences
RNA
|
$ 13.43
|
1.85 B
|
$ -586 M
|
-3.2
|
86.9
|
$ -4.0
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 31.83
|
1.83 B
|
$ 250 M
|
9.9
|
2.2
|
$ 3.2
|
 |
 |
Relay Therapeutics
RLAY
|
$ 12.72
|
1.82 B
|
$ -356 M
|
-6.7
|
42.5
|
$ -1.9
|
 |
 |
Vericel Corporation
VCEL
|
$ 35.57
|
1.79 B
|
$ -4.45 M
|
-217.1
|
7.2
|
$ -0.2
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 9.43
|
1.77 B
|
$ -136 M
|
-6.8
|
32.4
|
$ -1.4
|
 |
 |
Ardelyx
ARDX
|
$ 6.88
|
1.66 B
|
$ -107 M
|
-14.7
|
4.4
|
$ -0.4
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 19.11
|
1.64 B
|
$ -130 M
|
-6.1
|
15.8
|
$ -3.5
|
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 28.16
|
1.63 B
|
$ -381 M
|
2.4
|
31.9
|
$ 11.5
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 18.07
|
1.61 B
|
$ 16.5 M
|
186.4
|
19.1
|
$ 0.1
|
 |
 |
Innoviva
INVA
|
$ 23.11
|
1.56 B
|
$ 194 M
|
14.5
|
4.0
|
$ 1.6
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 80.39
|
1.55 B
|
$ 140 M
|
80.2
|
2.0
|
$ 1.0
|
 |
 |
Immunic
IMUX
|
$ 9.65
|
1.5 B
|
$ -105 M
|
-11.7
|
∙ |
$ -0.8
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 16.81
|
1.46 B
|
$ -235 M
|
-5.6
|
18.9
|
$ -3.0
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 30.91
|
1.44 B
|
$ -90.2 M
|
-16.6
|
90.1
|
$ -2.0
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 26.65
|
1.44 B
|
$ -159 M
|
-7.1
|
32.8
|
$ -3.8
|
 |
 |
Vir Biotechnology
VIR
|
$ 10.0
|
1.39 B
|
$ -669 M
|
-2.2
|
204.9
|
$ -4.6
|
 |
 |
Zymeworks
ZYME
|
$ 26.61
|
1.37 B
|
$ -268 M
|
-6.0
|
162.7
|
$ -4.6
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 13.42
|
1.37 B
|
$ -251 M
|
-3.3
|
19.4
|
$ -4.0
|
 |
 |
AbCellera Biologics
ABCL
|
$ 4.43
|
1.32 B
|
$ -229 M
|
-6.6
|
33.7
|
$ -0.6
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 13.26
|
1.31 B
|
$ -477 M
|
-3.1
|
24.8
|
$ -4.3
|
 |
 |
Novavax
NVAX
|
$ 8.04
|
1.3 B
|
$ -17.9 M
|
4.2
|
1.2
|
$ 1.9
|
 |
 |
Precigen
PGEN
|
$ 4.08
|
1.28 B
|
$ 14.9 M
|
-2.9
|
56.0
|
$ -1.4
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 14.32
|
1.25 B
|
$ -121 M
|
-7.4
|
∙ |
$ -2.0
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 7.32
|
1.23 B
|
$ -142 M
|
-6.7
|
15.7
|
$ -1.0
|
 |
 |
Savara
SVRA
|
$ 5.12
|
1.14 B
|
$ -116 M
|
-10.3
|
1465.8
|
$ -0.5
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 23.0
|
1.11 B
|
$ -112 M
|
-7.8
|
11.6
|
$ -3.1
|
 |
 |
uniQure N.V.
QURE
|
$ 19.13
|
1.1 B
|
$ -211 M
|
-5.2
|
89.5
|
$ -3.8
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 34.32
|
1.09 B
|
$ 158 M
|
19.3
|
1.4
|
$ 1.8
|
 |
 |
Geron Corporation
GERN
|
$ 1.58
|
1.05 B
|
$ -152 M
|
-12.8
|
6.2
|
$ -0.1
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 21.88
|
1.02 B
|
$ 211 M
|
9.2
|
1.4
|
$ 2.4
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 6.28
|
1.01 B
|
$ 3.68 M
|
-21.9
|
3.8
|
$ -0.3
|
 |
 |
Certara
CERT
|
$ 6.18
|
991 M
|
$ 65.2 M
|
306.5
|
2.4
|
$ 0.0
|
 |
 |
Seres Therapeutics
MCRB
|
$ 7.61
|
974 M
|
$ -99.2 M
|
0.5
|
7.4
|
$ 14.1
|
 |
 |
Omeros Corporation
OMER
|
$ 15.06
|
956 M
|
$ -128 M
|
-7.2
|
10.2
|
$ -2.0
|
 |
 |
Xencor
XNCR
|
$ 12.69
|
942 M
|
$ -169 M
|
-6.4
|
7.7
|
$ -1.9
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 2.83
|
908 M
|
$ -24.3 M
|
-21.2
|
∙ |
$ -0.1
|
 |
 |
Annexon
ANNX
|
$ 5.75
|
892 M
|
$ -180 M
|
-4.9
|
∙ |
$ -1.2
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 12.01
|
876 M
|
$ -296 M
|
-2.1
|
8.9
|
$ -5.2
|
 |
 |
MannKind Corporation
MNKD
|
$ 2.84
|
868 M
|
$ 67.5 M
|
28.3
|
2.8
|
$ 0.1
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 9.77
|
858 M
|
$ -112 M
|
-5.8
|
∙ |
$ -1.7
|
 |
 |
Theravance Biopharma
TBPH
|
$ 16.79
|
845 M
|
$ -131 M
|
29.9
|
10.9
|
$ 0.6
|
 |
 |
Sana Biotechnology
SANA
|
$ 3.27
|
828 M
|
$ -237 M
|
-3.3
|
∙ |
$ -1.0
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.32
|
828 M
|
$ -78.1 M
|
-16.2
|
56.0
|
$ -0.3
|
 |
 |
Burford Capital Limited
BUR
|
$ 5.2
|
820 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Cullinan Management
CGEM
|
$ 13.43
|
809 M
|
$ -190 M
|
-4.1
|
41.5
|
$ -3.2
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 28.9
|
778 M
|
$ -2.42 M
|
-114.9
|
9.4
|
$ -0.2
|
 |
 |
Kura Oncology
KURA
|
$ 8.77
|
769 M
|
$ -118 M
|
-3.1
|
15.4
|
$ -2.9
|
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 9.41
|
757 M
|
$ -160 M
|
-4.3
|
48.5
|
$ -2.2
|
 |
 |
Arvinas
ARVN
|
$ 10.51
|
745 M
|
$ -101 M
|
-11.5
|
2.0
|
$ -0.9
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 15.46
|
742 M
|
$ -37.9 M
|
-24.9
|
∙ |
$ -0.6
|
 |
 |
Ironwood Pharmaceuticals
IRWD
|
$ 4.44
|
706 M
|
$ 113 M
|
21.7
|
1.9
|
$ 0.2
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 3.11
|
646 M
|
$ -164 M
|
-3.4
|
1.4
|
$ -0.6
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 9.63
|
623 M
|
$ -651 M
|
-0.6
|
1.0
|
$ -15.0
|
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.63
|
592 M
|
$ -124 M
|
-5.8
|
12.7
|
$ -0.3
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 4.18
|
577 M
|
$ -53.6 M
|
60.3
|
7.0
|
$ 0.1
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 10.64
|
572 M
|
$ -256 M
|
-2.1
|
55.9
|
$ -5.2
|
 |
 |
Ocugen
OCGN
|
$ 1.8
|
562 M
|
$ -74.6 M
|
-6.9
|
94.1
|
$ -0.2
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 4.41
|
541 M
|
$ -63.6 M
|
-9.0
|
48.9
|
$ -0.5
|
 |
 |
SELLAS Life Sciences Group
SLS
|
$ 4.93
|
538 M
|
$ -39.5 M
|
-16.5
|
45.0
|
$ -0.3
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 29.4
|
529 M
|
$ 119 M
|
4.6
|
1.9
|
$ 6.2
|
 |
 |
Cerus Corporation
CERS
|
$ 2.72
|
518 M
|
$ -26.3 M
|
-20.3
|
3.0
|
$ -0.1
|
 |
 |
Tenax Therapeutics
TENX
|
$ 12.78
|
501 M
|
$ 1.23 M
|
-11.5
|
1368.6
|
$ -1.1
|
 |
 |
XOMA Corporation
XOMA
|
$ 41.38
|
500 M
|
$ 5.72 M
|
-124.1
|
10.8
|
$ -0.3
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 3.73
|
492 M
|
$ -264 M
|
-3.1
|
2.1
|
$ -1.2
|
 |
 |
Benitec Biopharma
BNTC
|
$ 11.95
|
492 M
|
$ -44.1 M
|
-12.3
|
3815.3
|
$ -1.0
|
 |
 |
Shattuck Labs
STTK
|
$ 6.99
|
486 M
|
$ -76.3 M
|
-7.3
|
74.0
|
$ -1.0
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 2.15
|
474 M
|
$ -295 M
|
-2.1
|
4895.1
|
$ -1.0
|
 |
 |
Plus Therapeutics
PSTV
|
$ 6.09
|
474 M
|
$ -15.7 M
|
-3.1
|
88.4
|
$ -2.0
|
 |
 |
REGENXBIO
RGNX
|
$ 9.12
|
470 M
|
$ -246 M
|
-1.9
|
4.7
|
$ -4.8
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 5.58
|
455 M
|
$ -166 M
|
-3.2
|
2.8
|
$ -1.7
|
 |
 |
Aquestive Therapeutics
AQST
|
$ 4.2
|
449 M
|
$ -30.5 M
|
-9.3
|
7.8
|
$ -0.4
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 3.65
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 1.09
|
428 M
|
$ -59.3 M
|
5.7
|
9.2
|
$ 0.2
|
 |
 |
Keros Therapeutics
KROS
|
$ 11.49
|
428 M
|
$ 38 M
|
8.5
|
1.7
|
$ 1.3
|
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 7.0
|
413 M
|
$ -95.2 M
|
-6.3
|
2.1
|
$ -1.1
|
 |
 |
Verastem
VSTM
|
$ 5.84
|
405 M
|
$ -109 M
|
-1.6
|
14.6
|
$ -3.3
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 53.25
|
395 M
|
$ -12.1 M
|
-33.0
|
∙ |
$ -1.6
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.47
|
391 M
|
$ -258 M
|
-1.3
|
6.1
|
$ -1.0
|
 |
 |
Puma Biotechnology
PBYI
|
$ 7.49
|
375 M
|
$ 45.4 M
|
9.8
|
1.6
|
$ 0.8
|
 |
 |
Forte Biosciences
FBRX
|
$ 28.19
|
365 M
|
$ -30.3 M
|
-3.4
|
19.1
|
$ -7.9
|
 |
 |
Ovid Therapeutics
OVID
|
$ 2.79
|
363 M
|
$ -43 M
|
-6.8
|
53.8
|
$ -0.4
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 4.7
|
362 M
|
$ -126 M
|
-3.4
|
42.4
|
$ -1.5
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.4
|
360 M
|
$ -3.97 M
|
-6.9
|
1.6
|
$ -0.2
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.53
|
352 M
|
$ -33.3 M
|
-5.0
|
29.6
|
$ -0.3
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 3.56
|
338 M
|
$ -251 M
|
-1.5
|
∙ |
$ -2.3
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 4.8
|
333 M
|
$ -260 M
|
-1.3
|
13.1
|
$ -3.5
|
 |
 |
SIGA Technologies
SIGA
|
$ 4.6
|
329 M
|
$ 50.6 M
|
11.0
|
3.3
|
$ 0.4
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 3.94
|
327 M
|
$ -63.6 M
|
-2.4
|
∙ |
$ -1.7
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 8.89
|
322 M
|
$ -31.2 M
|
-6.6
|
11666.7
|
$ -1.5
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 23.7
|
308 M
|
$ -14.2 M
|
-22.5
|
∙ |
$ -1.0
|
 |
 |
Assembly Biosciences
ASMB
|
$ 27.37
|
307 M
|
$ -63.1 M
|
-5.7
|
8.2
|
$ -4.7
|
 |
 |
Sutro Biopharma
STRO
|
$ 35.59
|
302 M
|
$ -179 M
|
-15.8
|
3.1
|
$ -2.3
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 4.76
|
300 M
|
$ -83 M
|
-4.2
|
10.2
|
$ -1.1
|
 |
 |
Cabaletta Bio
CABA
|
$ 2.94
|
295 M
|
$ -67.8 M
|
-1.3
|
∙ |
$ -2.4
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 4.09
|
294 M
|
$ -166 M
|
-2.0
|
7.4
|
$ -2.0
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 6.18
|
290 M
|
$ -22.5 M
|
-8.9
|
568.5
|
$ -0.7
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 5.43
|
288 M
|
$ -79.6 M
|
5.0
|
46.3
|
$ 1.1
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 3.32
|
283 M
|
$ -51.1 M
|
-6.8
|
∙ |
$ -0.5
|
 |
 |
Kamada Ltd.
KMDA
|
$ 8.21
|
260 M
|
$ 6.96 M
|
62.6
|
4.5
|
$ 0.1
|
 |
 |
Editas Medicine
EDIT
|
$ 2.9
|
257 M
|
$ -242 M
|
-1.2
|
16.8
|
$ -2.6
|
 |
 |
Compugen Ltd.
CGEN
|
$ 2.71
|
253 M
|
∙ |
∙ |
31.1
|
∙ |
 |
 |
BioAtla
BCAB
|
$ 4.27
|
251 M
|
$ -95.6 M
|
-3.9
|
412.8
|
$ -1.1
|
 |
 |
Rezolute
RZLT
|
$ 3.3
|
251 M
|
$ -67 M
|
-3.6
|
∙ |
$ -0.9
|
 |
 |
Altimmune
ALT
|
$ 2.82
|
248 M
|
$ -95.3 M
|
-2.4
|
11453.5
|
$ -1.1
|
 |
 |
Alector
ALEC
|
$ 2.36
|
243 M
|
$ -178 M
|
-1.6
|
8.1
|
$ -1.5
|
 |
 |
C4 Therapeutics
CCCC
|
$ 2.92
|
242 M
|
$ -119 M
|
-1.8
|
5.8
|
$ -1.5
|
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 8.63
|
236 M
|
$ -56.6 M
|
-5.0
|
1.7
|
$ -1.7
|
 |
 |
Codexis
CDXS
|
$ 2.67
|
233 M
|
$ -63.9 M
|
-3.1
|
5.6
|
$ -0.9
|
 |
 |
Protara Therapeutics
TARA
|
$ 5.32
|
228 M
|
$ -43.3 M
|
-3.7
|
77.4
|
$ -1.4
|
 |
 |
Adagene
ADAG
|
$ 3.82
|
225 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Voyager Therapeutics
VYGR
|
$ 3.76
|
221 M
|
$ 95.1 M
|
-2.2
|
4.4
|
$ -1.7
|
 |
 |
Anika Therapeutics
ANIK
|
$ 14.85
|
218 M
|
$ -6.4 M
|
-4.4
|
1.6
|
$ -2.8
|
 |
 |
Nkarta
NKTX
|
$ 2.93
|
217 M
|
$ -116 M
|
-2.0
|
1747.2
|
$ -1.4
|
 |
 |
Heron Therapeutics
HRTX
|
$ 1.27
|
212 M
|
$ -72.5 M
|
-9.2
|
1.4
|
$ -0.1
|
 |
 |
Coherus BioSciences
CHRS
|
$ 1.8
|
211 M
|
$ -181 M
|
1.1
|
5.9
|
$ 1.7
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 75.61
|
211 M
|
$ -28.2 M
|
57.8
|
20.8
|
$ 1.3
|
 |
 |
Replimune Group
REPL
|
$ 2.5
|
201 M
|
$ -309 M
|
-0.8
|
∙ |
$ -3.4
|
 |
 |
Milestone Pharmaceuticals
MIST
|
$ 1.87
|
199 M
|
$ -61.4 M
|
-2.3
|
∙ |
$ -0.8
|
 |
 |
MacroGenics
MGNX
|
$ 3.13
|
198 M
|
$ -145 M
|
-61.6
|
0.9
|
$ -0.0
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 4.38
|
191 M
|
$ 448 K
|
-3.2
|
∙ |
$ -1.4
|
 |
 |
Inhibikase Therapeutics
IKT
|
$ 1.91
|
188 M
|
$ -44 M
|
-1.8
|
693.8
|
$ -1.0
|
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 6.54
|
187 M
|
$ -20.6 M
|
-17.1
|
4.9
|
$ -0.4
|
 |
 |
Fate Therapeutics
FATE
|
$ 1.53
|
182 M
|
$ -186 M
|
-1.0
|
17.8
|
$ -1.3
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 4.19
|
177 M
|
$ -9.29 M
|
-0.4
|
36.1
|
$ -9.6
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 2.12
|
167 M
|
$ -12.8 M
|
-215.0
|
2.7
|
$ -0.0
|
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 3.98
|
165 M
|
$ -20.7 M
|
4.8
|
39.9
|
$ 0.8
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.6
|
148 M
|
$ -91.7 M
|
-2.7
|
∙ |
$ -1.0
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 2.28
|
145 M
|
$ -22.2 M
|
-2.4
|
609.6
|
$ -1.3
|
 |
 |
Galectin Therapeutics
GALT
|
$ 2.27
|
145 M
|
$ -36 M
|
-3.9
|
-372.0
|
$ -0.6
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.48
|
139 M
|
$ -80.8 M
|
-3.4
|
3.6
|
$ -0.7
|
 |
 |
Corbus Pharmaceuticals Holdings
CRBP
|
$ 10.3
|
137 M
|
$ -78.4 M
|
-1.7
|
62.3
|
$ -5.9
|
 |
 |
Seer
SEER
|
$ 2.03
|
130 M
|
$ -96.5 M
|
-1.4
|
8.7
|
$ -1.4
|
 |
 |
vTv Therapeutics
VTVT
|
$ 31.69
|
125 M
|
$ -23.5 M
|
∙ |
25.3
|
∙ |
 |
 |
Equillium
EQ
|
$ 2.08
|
119 M
|
$ -28.8 M
|
-4.5
|
2.6
|
$ -0.4
|
 |
 |
Cellectis S.A.
CLLS
|
$ 3.95
|
116 M
|
$ -106 M
|
-1.6
|
7.6
|
$ -2.4
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 13.6
|
116 M
|
$ -91.1 M
|
-0.4
|
10.4
|
$ -33.0
|
 |
 |
Cardiff Oncology
CRDF
|
$ 1.71
|
114 M
|
$ -53.4 M
|
-2.1
|
224.5
|
$ -0.8
|
 |
 |
Agenus
AGEN
|
$ 3.84
|
114 M
|
$ -128 M
|
-1.3
|
1.1
|
$ -3.1
|
 |
 |
ADC Therapeutics SA
ADCT
|
$ 3.83
|
105 M
|
$ -239 M
|
-1.4
|
6.2
|
$ -2.8
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 1.59
|
95.5 M
|
$ -51 M
|
-2.1
|
∙ |
$ -0.7
|
 |
 |
ALX Oncology Holdings
ALXO
|
$ 1.69
|
90.7 M
|
$ -113 M
|
-0.8
|
25.2
|
$ -2.1
|
 |
 |
Gossamer Bio
GOSS
|
$ 0.37
|
84.6 M
|
$ -59.8 M
|
-0.5
|
1.9
|
$ -0.7
|
 |
 |
Champions Oncology
CSBR
|
$ 5.99
|
81.8 M
|
$ 5.92 M
|
18.1
|
1.3
|
$ 0.3
|
 |
 |
ImmuCell Corporation
ICCC
|
$ 8.73
|
78.8 M
|
$ 3.86 M
|
76.9
|
2.9
|
$ 0.1
|
 |
 |
XBiotech
XBIT
|
$ 2.55
|
77.7 M
|
$ -34.4 M
|
-3.3
|
9.5
|
$ -0.8
|
 |
 |
Pliant Therapeutics
PLRX
|
$ 1.2
|
73.6 M
|
$ -193 M
|
-0.4
|
9.3
|
$ -3.0
|
 |
 |
PMV Pharmaceuticals
PMVP
|
$ 1.39
|
73 M
|
$ -88.4 M
|
-0.9
|
∙ |
$ -1.5
|
 |
 |
PolyPid Ltd.
PYPD
|
$ 4.44
|
72.6 M
|
$ -17.9 M
|
0.2
|
∙ |
$ 25.9
|
 |
 |
Tiziana Life Sciences PLC
TLSA
|
$ 1.34
|
71.5 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
MediciNova
MNOV
|
$ 1.4
|
68.7 M
|
$ -13.2 M
|
-5.6
|
52.6
|
$ -0.2
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 6.27
|
66.8 M
|
$ -25.5 M
|
-1.3
|
2.4
|
$ -5.0
|
 |
 |
Fortress Biotech
FBIO
|
$ 2.33
|
65 M
|
$ -87.3 M
|
-3.8
|
1.0
|
$ -0.6
|
 |
 |
BeyondSpring
BYSI
|
$ 1.5
|
61.7 M
|
$ -71 M
|
-76.0
|
61.7
|
$ -0.0
|
 |
 |
Atara Biotherapeutics
ATRA
|
$ 4.9
|
61.5 M
|
$ -27.9 M
|
9.9
|
0.4
|
$ 0.5
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 6.09
|
60.2 M
|
$ -85.3 M
|
-2.4
|
18.1
|
$ -2.5
|
 |
 |
Entera Bio Ltd.
ENTX
|
$ 1.1
|
59.9 M
|
$ -8.21 M
|
2.4
|
275.7
|
$ 0.5
|
 |
 |
Edesa Biotech
EDSA
|
$ 17.59
|
56.2 M
|
$ -7.65 M
|
-14.0
|
89.0
|
$ -1.3
|
 |
 |
Kezar Life Sciences
KZR
|
$ 7.33
|
53.6 M
|
$ -64.9 M
|
-0.9
|
7.6
|
$ -8.4
|
 |
 |
Minerva Neurosciences
NERV
|
$ 6.07
|
51.4 M
|
$ -21.1 M
|
3.8
|
0.7
|
$ 1.7
|
 |