 |
Eli Lilly and Company
LLY
|
$ 1 062.46
|
957 B
|
$ 2.37 B
|
74.6
|
18.1
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 214.88
|
517 B
|
$ 9.42 B
|
20.9
|
5.5
|
$ 10.1
|
 |
 |
AbbVie
ABBV
|
$ 227.13
|
402 B
|
$ 15.1 B
|
100.1
|
6.7
|
$ 2.2
|
 |
 |
Merck & Co.
MRK
|
$ 100.52
|
255 B
|
$ 2.86 B
|
13.6
|
3.9
|
$ 7.3
|
 |
 |
Novartis AG
NVS
|
$ 135.17
|
227 B
|
$ 10.7 B
|
22.7
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 324.86
|
174 B
|
$ 12.4 B
|
23.9
|
6.4
|
$ 13.2
|
 |
 |
Pfizer
PFE
|
$ 26.59
|
151 B
|
$ 6.66 B
|
10.6
|
2.3
|
$ 2.4
|
 |
 |
Gilead Sciences
GILD
|
$ 119.96
|
150 B
|
$ 9.3 B
|
19.8
|
5.2
|
$ 6.1
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 455.11
|
117 B
|
$ 4.29 B
|
30.5
|
10.1
|
$ 14.8
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 54.71
|
111 B
|
$ 11 B
|
16.0
|
2.2
|
$ 3.3
|
 |
 |
AstraZeneca PLC
AZN
|
$ 91.59
|
96.9 B
|
$ 3.67 B
|
66.0
|
3.8
|
$ 1.4
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 752.21
|
81.2 B
|
$ 4.1 B
|
15.9
|
5.7
|
$ 46.5
|
 |
 |
Zoetis
ZTS
|
$ 120.71
|
54.8 B
|
$ 487 M
|
19.3
|
5.7
|
$ 6.2
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 390.98
|
49.9 B
|
$ -361 M
|
-202.1
|
19.9
|
$ -2.0
|
 |
 |
Axon Enterprise
AXON
|
$ 548.58
|
41.6 B
|
$ 89.9 M
|
146.3
|
23.2
|
$ 3.9
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 30.16
|
34.1 B
|
$ 2.81 B
|
69.1
|
2.0
|
$ 0.4
|
 |
 |
Insmed Incorporated
INSM
|
$ 196.41
|
32.2 B
|
$ -1.06 B
|
-31.1
|
84.2
|
$ -6.3
|
 |
 |
Biogen
BIIB
|
$ 175.2
|
25.5 B
|
$ 2.03 B
|
13.8
|
2.5
|
$ 12.7
|
 |
 |
argenx SE
ARGX
|
$ 847.25
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
United Therapeutics Corporation
UTHR
|
$ 499.04
|
22.6 B
|
$ 1.42 B
|
18.1
|
7.3
|
$ 27.2
|
 |
 |
Incyte Corporation
INCY
|
$ 99.31
|
20.6 B
|
$ 573 M
|
66.7
|
4.4
|
$ 1.4
|
 |
 |
Legend Biotech Corporation
LEGN
|
$ 22.09
|
18.7 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Royalty Pharma plc
RPRX
|
$ 38.56
|
17.3 B
|
$ 1.1 B
|
15.3
|
7.4
|
$ 2.5
|
 |
 |
Zai Lab Limited
ZLAB
|
$ 17.35
|
17.2 B
|
$ -218 M
|
-118.5
|
40.5
|
$ -0.2
|
 |
 |
Pulmatrix
PULM
|
$ 4.43
|
16.2 B
|
$ -13.2 M
|
-5.4
|
1800.0
|
$ -0.9
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 153.68
|
15.4 B
|
$ 124 M
|
49.0
|
6.2
|
$ 3.1
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 74.67
|
13.9 B
|
$ -603 M
|
-24.3
|
60.1
|
$ -3.1
|
 |
 |
Revolution Medicines
RVMD
|
$ 79.41
|
13.3 B
|
$ -989 M
|
-15.8
|
567.5
|
$ -5.0
|
 |
 |
Summit Therapeutics
SMMT
|
$ 17.45
|
12.5 B
|
$ -609 M
|
-14.1
|
6232.8
|
$ -1.2
|
 |
 |
Exelixis
EXEL
|
$ 41.3
|
12 B
|
$ 363 M
|
17.2
|
5.2
|
$ 2.4
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 560.8
|
11.9 B
|
$ -389 M
|
-37.6
|
17.4
|
$ -15.2
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 79.68
|
11.9 B
|
$ -451 M
|
-51.9
|
12.8
|
$ -1.6
|
 |
 |
Moderna
MRNA
|
$ 30.22
|
11.6 B
|
$ -2.09 B
|
-5.8
|
3.7
|
$ -5.1
|
 |
 |
Mesoblast Limited
MESO
|
$ 17.78
|
11.5 B
|
∙ |
-2.4
|
1184.0
|
$ -7.6
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 13.29
|
11.4 B
|
$ -59 M
|
-270.6
|
110.7
|
$ -0.0
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 169.82
|
10.5 B
|
$ 73.8 M
|
-29.8
|
2.5
|
$ -5.6
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 53.16
|
10.1 B
|
$ -373 M
|
-0.1
|
105.2
|
$ -791.5
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 52.16
|
9.91 B
|
$ 790 M
|
15.9
|
3.3
|
$ 3.3
|
 |
 |
Akari Therapeutics, Plc
AKTX
|
$ 0.39
|
9.32 B
|
$ -15.1 M
|
-4.7
|
∙ |
$ -0.1
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 58.55
|
9.22 B
|
$ 292 M
|
71.7
|
7.8
|
$ 0.8
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 68.73
|
9.19 B
|
$ -610 M
|
-13.9
|
189.1
|
$ -5.0
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 87.67
|
9.05 B
|
$ 80.9 M
|
76.2
|
12.3
|
$ 1.2
|
 |
 |
Avidity Biosciences
RNA
|
$ 71.8
|
8.01 B
|
$ -586 M
|
-17.8
|
396.3
|
$ -4.0
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 62.98
|
7.99 B
|
$ 736 M
|
12.7
|
6.4
|
$ 4.9
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 147.17
|
7.05 B
|
$ -197 M
|
-33.2
|
13.0
|
$ -4.5
|
 |
 |
Krystal Biotech
KRYS
|
$ 244.04
|
6.98 B
|
$ 145 M
|
39.1
|
19.1
|
$ 6.3
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 113.05
|
6.9 B
|
$ -189 M
|
-36.6
|
41.9
|
$ -3.1
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 85.81
|
6.44 B
|
$ -316 M
|
-25.4
|
168.1
|
$ -3.5
|
 |
 |
Merus N.V.
MRUS
|
$ 96.89
|
6.22 B
|
$ -205 M
|
-15.3
|
105.1
|
$ -6.4
|
 |
 |
Protagonist Therapeutics
PTGX
|
$ 95.57
|
5.88 B
|
$ 120 M
|
-50.0
|
135.2
|
$ -1.9
|
 |
 |
PTC Therapeutics
PTCT
|
$ 76.48
|
5.88 B
|
$ 906 M
|
8.4
|
3.3
|
$ 9.1
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 14.25
|
5.81 B
|
$ -48.8 M
|
-95.8
|
26.1
|
$ -0.2
|
 |
 |
Vaxcyte
PCVX
|
$ 44.34
|
5.41 B
|
$ -581 M
|
-9.6
|
∙ |
$ -4.6
|
 |
 |
Longeveron
LGVN
|
$ 0.56
|
5.27 B
|
$ -21.7 M
|
-0.4
|
3455.2
|
$ -1.4
|
 |
 |
Praxis Precision Medicines
PRAX
|
$ 275.99
|
4.94 B
|
$ -198 M
|
-21.1
|
3083.6
|
$ -12.7
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 56.32
|
4.75 B
|
$ -601 M
|
-9.2
|
1477.8
|
$ -6.2
|
 |
 |
Alkermes plc
ALKS
|
$ 28.17
|
4.66 B
|
$ 287 M
|
16.0
|
3.2
|
$ 1.8
|
 |
 |
TG Therapeutics
TGTX
|
$ 31.54
|
4.58 B
|
$ -72.3 M
|
10.7
|
9.0
|
$ 2.9
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 27.27
|
4.52 B
|
$ -213 M
|
-18.7
|
9.0
|
$ -1.4
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 44.9
|
4.48 B
|
$ -216 M
|
-14.6
|
44.6
|
$ -3.2
|
 |
 |
ADMA Biologics
ADMA
|
$ 19.77
|
4.43 B
|
$ 176 M
|
36.0
|
9.0
|
$ 0.6
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 49.45
|
3.99 B
|
$ -274 M
|
-10.9
|
2098.5
|
$ -4.6
|
 |
 |
Viking Therapeutics
VKTX
|
$ 36.24
|
3.95 B
|
$ -201 M
|
-26.3
|
∙ |
$ -1.4
|
 |
 |
Immunovant
IMVT
|
$ 26.05
|
3.95 B
|
$ 324 K
|
-8.9
|
∙ |
$ -2.9
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 12.51
|
3.87 B
|
$ 545 M
|
87.2
|
1.3
|
$ 0.1
|
 |
 |
Akero Therapeutics
AKRO
|
$ 54.65
|
3.67 B
|
$ -115 M
|
-14.7
|
∙ |
$ -3.7
|
 |
 |
Inhibrx
INBX
|
$ 75.75
|
3.57 B
|
$ -160 M
|
-19.2
|
8573.6
|
$ -4.2
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 194.05
|
3.55 B
|
$ 60.8 M
|
51.8
|
13.3
|
$ 3.6
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 29.08
|
3.52 B
|
$ -142 M
|
-26.8
|
15.7
|
$ -1.1
|
 |
 |
Mersana Therapeutics
MRSN
|
$ 28.62
|
3.51 B
|
$ 1.7 M
|
-3.2
|
117.8
|
$ -8.9
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 43.67
|
3.4 B
|
$ -216 M
|
-11.4
|
202.8
|
$ -3.9
|
 |
 |
Spruce Biosciences
SPRB
|
$ 81.01
|
3.34 B
|
$ -51.8 M
|
-2.4
|
464.5
|
$ -34.2
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 36.45
|
3.3 B
|
$ -664 M
|
-6.1
|
9.4
|
$ -6.0
|
 |
 |
Amicus Therapeutics
FOLD
|
$ 10.75
|
3.27 B
|
$ 46.2 M
|
-92.6
|
5.2
|
$ -0.1
|
 |
 |
Veracyte
VCYT
|
$ 43.47
|
3.16 B
|
$ 48.4 M
|
82.8
|
6.4
|
$ 0.5
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 81.39
|
3.06 B
|
$ -87.3 M
|
-40.3
|
8.8
|
$ -2.0
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 24.59
|
3.05 B
|
$ -471 M
|
-13.7
|
4.2
|
$ -1.8
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 63.95
|
3.04 B
|
$ -6.4 M
|
-98.6
|
6.7
|
$ -0.7
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 41.57
|
2.97 B
|
$ 24.2 M
|
345.1
|
5.7
|
$ 0.1
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 24.29
|
2.88 B
|
$ 152 M
|
14.0
|
5.0
|
$ 1.7
|
 |
 |
Denali Therapeutics
DNLI
|
$ 17.48
|
2.88 B
|
$ -471 M
|
-6.3
|
8.9
|
$ -2.9
|
 |
 |
IDEAYA Biosciences
IDYA
|
$ 33.39
|
2.73 B
|
$ -129 M
|
-35.9
|
12.2
|
$ -1.0
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 32.9
|
2.66 B
|
$ -251 M
|
-8.0
|
37.1
|
$ -4.0
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 47.53
|
2.62 B
|
$ 4.48 M
|
524.7
|
3.8
|
$ 0.1
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 15.86
|
2.33 B
|
$ -60.1 M
|
-29.1
|
9.0
|
$ -0.5
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 14.27
|
2.26 B
|
$ -136 M
|
-10.7
|
42.8
|
$ -1.4
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 15.71
|
2.25 B
|
$ 60.9 M
|
31.0
|
8.4
|
$ 0.5
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 16.25
|
2.25 B
|
$ -145 M
|
-11.5
|
44.2
|
$ -1.4
|
 |
 |
Liquidia Corporation
LQDA
|
$ 34.33
|
2.23 B
|
$ -99.1 M
|
-24.3
|
30.8
|
$ -1.4
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 38.96
|
2.22 B
|
$ 250 M
|
12.7
|
2.8
|
$ 3.2
|
 |
 |
Beam Therapeutics
BEAM
|
$ 26.77
|
2.2 B
|
$ -451 M
|
-6.1
|
56.5
|
$ -4.5
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 21.6
|
2.05 B
|
$ -254 M
|
-5.3
|
0.9
|
$ -4.0
|
 |
 |
Seres Therapeutics
MCRB
|
$ 15.87
|
2.03 B
|
$ -99.2 M
|
1.2
|
17.2
|
$ 14.1
|
 |
 |
Arcus Biosciences
RCUS
|
$ 21.29
|
1.92 B
|
$ -281 M
|
-6.8
|
7.1
|
$ -3.2
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 18.47
|
1.79 B
|
$ -83 M
|
-15.0
|
403.4
|
$ -1.2
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 20.86
|
1.79 B
|
$ -130 M
|
-5.8
|
15.0
|
$ -3.5
|
 |
 |
Vericel Corporation
VCEL
|
$ 36.52
|
1.78 B
|
$ -4.45 M
|
-229.1
|
7.4
|
$ -0.2
|
 |
 |
MannKind Corporation
MNKD
|
$ 5.9
|
1.62 B
|
$ 67.5 M
|
60.0
|
5.4
|
$ 0.1
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 35.67
|
1.61 B
|
$ -121 M
|
-16.9
|
∙ |
$ -2.0
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 81.88
|
1.58 B
|
$ 140 M
|
81.1
|
2.0
|
$ 1.0
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 7.65
|
1.58 B
|
$ -37 M
|
-151.8
|
2.7
|
$ -0.0
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 49.12
|
1.58 B
|
$ 158 M
|
27.8
|
2.1
|
$ 1.8
|
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 26.7
|
1.52 B
|
$ -381 M
|
2.4
|
40.2
|
$ 11.5
|
 |
 |
Stoke Therapeutics
STOK
|
$ 33.13
|
1.46 B
|
$ 33.6 M
|
75.5
|
7.6
|
$ 0.4
|
 |
 |
Ardelyx
ARDX
|
$ 6.18
|
1.45 B
|
$ -107 M
|
-14.5
|
4.3
|
$ -0.4
|
 |
 |
Burford Capital Limited
BUR
|
$ 8.97
|
1.45 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Taysha Gene Therapies
TSHA
|
$ 5.77
|
1.44 B
|
$ -107 M
|
-16.1
|
202.2
|
$ -0.4
|
 |
 |
Dynavax Technologies Corporation
DVAX
|
$ 10.87
|
1.41 B
|
$ -3.96 M
|
-43.4
|
4.2
|
$ -0.2
|
 |
 |
Cidara Therapeutics
CDTX
|
$ 220.09
|
1.4 B
|
$ -15.9 M
|
-24.9
|
89.8
|
$ -8.9
|
 |
 |
Certara
CERT
|
$ 8.68
|
1.39 B
|
$ 65.2 M
|
428.5
|
3.4
|
$ 0.0
|
 |
 |
RAPT Therapeutics
RAPT
|
$ 33.78
|
1.38 B
|
$ -77 M
|
-7.1
|
373.2
|
$ -5.2
|
 |
 |
Zymeworks
ZYME
|
$ 26.08
|
1.34 B
|
$ -268 M
|
-5.5
|
151.2
|
$ -4.6
|
 |
 |
AnaptysBio
ANAB
|
$ 45.5
|
1.29 B
|
$ -143 M
|
-13.9
|
8.1
|
$ -3.2
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 19.13
|
1.28 B
|
$ -190 M
|
-6.7
|
15.7
|
$ -2.9
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 26.45
|
1.28 B
|
$ 211 M
|
10.5
|
1.7
|
$ 2.4
|
 |
 |
Innoviva
INVA
|
$ 20.25
|
1.27 B
|
$ 194 M
|
13.0
|
3.4
|
$ 1.6
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 12.62
|
1.25 B
|
$ -39.2 M
|
-33.0
|
∙ |
$ -0.4
|
 |
 |
Relay Therapeutics
RLAY
|
$ 8.48
|
1.21 B
|
$ -356 M
|
-4.2
|
26.3
|
$ -1.9
|
 |
 |
Kodiak Sciences
KOD
|
$ 22.91
|
1.2 B
|
$ -244 M
|
-5.8
|
∙ |
$ -4.1
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 42.0
|
1.17 B
|
$ -28.2 M
|
29.9
|
107.7
|
$ 1.3
|
 |
 |
Xencor
XNCR
|
$ 16.81
|
1.09 B
|
$ -169 M
|
-8.8
|
9.4
|
$ -1.9
|
 |
 |
Savara
SVRA
|
$ 6.61
|
1.09 B
|
$ -116 M
|
-13.6
|
1444.2
|
$ -0.5
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 7.1
|
1.04 B
|
$ 3.68 M
|
-25.5
|
4.0
|
$ -0.3
|
 |
 |
AbCellera Biologics
ABCL
|
$ 3.51
|
1.03 B
|
$ -229 M
|
-5.8
|
29.2
|
$ -0.6
|
 |
 |
Novavax
NVAX
|
$ 6.6
|
1 B
|
$ -17.9 M
|
3.5
|
0.9
|
$ 1.9
|
 |
 |
FibroGen
FGEN
|
$ 10.28
|
1 B
|
$ -263 M
|
0.2
|
232.5
|
$ 39.6
|
 |
 |
Sana Biotechnology
SANA
|
$ 5.12
|
996 M
|
$ -237 M
|
-5.1
|
∙ |
$ -1.0
|
 |
 |
uniQure N.V.
QURE
|
$ 20.17
|
981 M
|
$ -211 M
|
-5.2
|
75.3
|
$ -3.8
|
 |
 |
Precigen
PGEN
|
$ 3.83
|
937 M
|
$ 14.9 M
|
-2.6
|
38.6
|
$ -1.4
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 14.62
|
924 M
|
$ -296 M
|
-2.8
|
10.1
|
$ -5.2
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 3.29
|
908 M
|
$ -24.3 M
|
-24.4
|
∙ |
$ -0.1
|
 |
 |
Vir Biotechnology
VIR
|
$ 6.77
|
908 M
|
$ -669 M
|
-1.5
|
131.4
|
$ -4.6
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 9.1
|
900 M
|
$ -477 M
|
-2.1
|
17.0
|
$ -4.3
|
 |
 |
Kura Oncology
KURA
|
$ 10.42
|
898 M
|
$ -118 M
|
-3.5
|
17.6
|
$ -2.9
|
 |
 |
Arvinas
ARVN
|
$ 12.39
|
891 M
|
$ -101 M
|
-14.7
|
2.6
|
$ -0.9
|
 |
 |
Theravance Biopharma
TBPH
|
$ 17.9
|
874 M
|
$ -131 M
|
32.4
|
11.4
|
$ 0.6
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 12.98
|
854 M
|
$ 16.5 M
|
116.8
|
8.8
|
$ 0.1
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 16.95
|
842 M
|
$ -159 M
|
-4.5
|
19.3
|
$ -3.8
|
 |
 |
Galecto
GLTO
|
$ 31.24
|
830 M
|
$ -13 M
|
-3.1
|
∙ |
$ -10.3
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.93
|
818 M
|
$ -78.1 M
|
-18.3
|
54.8
|
$ -0.3
|
 |
 |
Replimune Group
REPL
|
$ 10.03
|
808 M
|
$ -296 M
|
-3.1
|
∙ |
$ -3.3
|
 |
 |
Keros Therapeutics
KROS
|
$ 21.19
|
793 M
|
$ 38 M
|
16.5
|
3.3
|
$ 1.3
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 12.14
|
780 M
|
$ -85.3 M
|
-5.4
|
265.5
|
$ -2.5
|
 |
 |
Geron Corporation
GERN
|
$ 1.35
|
770 M
|
$ -152 M
|
-11.3
|
4.7
|
$ -0.1
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 42.3
|
744 M
|
$ 119 M
|
6.6
|
2.6
|
$ 6.2
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 11.33
|
733 M
|
$ -651 M
|
-0.8
|
1.3
|
$ -15.0
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 26.67
|
714 M
|
$ -90.2 M
|
-12.9
|
40.2
|
$ -2.0
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 3.78
|
708 M
|
$ -164 M
|
-6.7
|
2.5
|
$ -0.6
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 3.85
|
685 M
|
$ -9.29 M
|
-0.4
|
146.1
|
$ -9.6
|
 |
 |
Annexon
ANNX
|
$ 4.92
|
676 M
|
$ -180 M
|
-4.2
|
∙ |
$ -1.2
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 22.69
|
654 M
|
$ -112 M
|
-7.2
|
6.4
|
$ -3.1
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 9.35
|
652 M
|
$ -112 M
|
-5.5
|
∙ |
$ -1.7
|
 |
 |
Cullinan Management
CGEM
|
$ 10.78
|
631 M
|
$ -190 M
|
-3.8
|
37.4
|
$ -3.2
|
 |
 |
Passage Bio
PASG
|
$ 10.1
|
610 M
|
$ -54.7 M
|
-0.8
|
∙ |
$ -11.8
|
 |
 |
REGENXBIO
RGNX
|
$ 13.92
|
609 M
|
$ -246 M
|
-2.9
|
6.3
|
$ -4.8
|
 |
 |
Sutro Biopharma
STRO
|
$ 10.01
|
602 M
|
$ -179 M
|
-4.3
|
6.0
|
$ -2.3
|
 |
 |
CorMedix
CRMD
|
$ 11.43
|
582 M
|
$ 47.5 M
|
5.9
|
3.0
|
$ 2.0
|
 |
 |
Gossamer Bio
GOSS
|
$ 3.76
|
574 M
|
$ -59.8 M
|
-5.4
|
12.7
|
$ -0.7
|
 |
 |
Ironwood Pharmaceuticals
IRWD
|
$ 3.58
|
570 M
|
$ 113 M
|
18.8
|
1.7
|
$ 0.2
|
 |
 |
Can-Fite BioPharma Ltd.
CANF
|
$ 0.26
|
566 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Omeros Corporation
OMER
|
$ 9.65
|
561 M
|
$ -128 M
|
-5.1
|
6.6
|
$ -2.0
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 10.01
|
538 M
|
$ -256 M
|
-2.0
|
52.5
|
$ -5.2
|
 |
 |
Aquestive Therapeutics
AQST
|
$ 5.94
|
515 M
|
$ -30.5 M
|
-14.3
|
9.6
|
$ -0.4
|
 |
 |
Benitec Biopharma
BNTC
|
$ 12.16
|
501 M
|
$ -34.3 M
|
-12.4
|
3815.3
|
$ -1.0
|
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 8.83
|
499 M
|
$ -160 M
|
-4.2
|
33.6
|
$ -2.2
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 3.62
|
478 M
|
$ -264 M
|
-3.0
|
2.1
|
$ -1.2
|
 |
 |
Kezar Life Sciences
KZR
|
$ 6.29
|
456 M
|
$ -64.9 M
|
-0.8
|
65.7
|
$ -8.4
|
 |
 |
SIGA Technologies
SIGA
|
$ 6.33
|
452 M
|
$ 50.6 M
|
15.4
|
4.6
|
$ 0.4
|
 |
 |
Immunome
IMNM
|
$ 22.36
|
444 M
|
$ -154 M
|
-7.7
|
37.3
|
$ -2.5
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 0.83
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 1.18
|
428 M
|
$ -59.3 M
|
6.4
|
9.2
|
$ 0.2
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 7.31
|
425 M
|
$ -260 M
|
-2.1
|
17.4
|
$ -3.5
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.63
|
416 M
|
$ -258 M
|
-1.5
|
6.7
|
$ -1.0
|
 |
 |
Galectin Therapeutics
GALT
|
$ 6.56
|
409 M
|
$ -36 M
|
-10.8
|
-1003.3
|
$ -0.6
|
 |
 |
Ocugen
OCGN
|
$ 1.4
|
408 M
|
$ -74.6 M
|
-5.5
|
69.5
|
$ -0.2
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 15.86
|
407 M
|
$ -2.42 M
|
-80.2
|
6.3
|
$ -0.2
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 8.4
|
403 M
|
$ -37.9 M
|
-13.8
|
∙ |
$ -0.6
|
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.25
|
400 M
|
$ -124 M
|
-4.7
|
9.1
|
$ -0.3
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 6.06
|
387 M
|
$ -24.4 M
|
-5.0
|
1251.1
|
$ -1.3
|
 |
 |
Altimmune
ALT
|
$ 5.41
|
384 M
|
$ -95.3 M
|
-5.0
|
18886.9
|
$ -1.1
|
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 6.6
|
384 M
|
$ -95.2 M
|
-5.5
|
1.8
|
$ -1.1
|
 |
 |
Cerus Corporation
CERS
|
$ 2.05
|
378 M
|
$ -31.5 M
|
-18.0
|
7.8
|
$ -0.1
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 4.12
|
351 M
|
$ -51.1 M
|
-7.0
|
∙ |
$ -0.6
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 4.14
|
350 M
|
$ -53.6 M
|
59.4
|
4.2
|
$ 0.1
|
 |
 |
Generation Bio Co.
GBIO
|
$ 5.38
|
347 M
|
$ -59.2 M
|
-0.8
|
18.8
|
$ -6.4
|
 |
 |
NextCure
NXTC
|
$ 11.9
|
333 M
|
$ -76.6 M
|
-0.6
|
4.7
|
$ -19.8
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 3.43
|
325 M
|
$ -251 M
|
-1.5
|
∙ |
$ -2.3
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 7.14
|
324 M
|
$ -25.5 M
|
-1.6
|
12.6
|
$ -5.0
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 18.88
|
322 M
|
$ -91.1 M
|
-0.6
|
31.0
|
$ -33.0
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.61
|
302 M
|
$ -3.97 M
|
-8.4
|
1.5
|
$ -0.2
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.69
|
292 M
|
$ -33.3 M
|
-5.6
|
24.7
|
$ -0.3
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 75.85
|
287 M
|
$ -12.1 M
|
-48.2
|
∙ |
$ -1.6
|
 |
 |
Puma Biotechnology
PBYI
|
$ 5.85
|
285 M
|
$ 45.4 M
|
7.5
|
1.2
|
$ 0.8
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 8.58
|
279 M
|
$ -22.5 M
|
-13.8
|
612.2
|
$ -0.7
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 3.17
|
267 M
|
$ -166 M
|
-1.8
|
1.7
|
$ -1.7
|
 |
 |
Kamada Ltd.
KMDA
|
$ 7.25
|
260 M
|
$ 6.96 M
|
54.1
|
4.5
|
$ 0.1
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 3.2
|
247 M
|
$ -63.6 M
|
-6.8
|
23.2
|
$ -0.5
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 4.09
|
243 M
|
$ -51 M
|
-6.4
|
∙ |
$ -0.7
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 4.38
|
240 M
|
$ -83 M
|
-3.9
|
8.3
|
$ -1.1
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 1.47
|
231 M
|
$ -295 M
|
-1.5
|
2501.1
|
$ -1.0
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 6.07
|
219 M
|
$ -31.2 M
|
-3.8
|
6633.2
|
$ -1.5
|
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 7.98
|
212 M
|
$ -20.6 M
|
-19.8
|
5.3
|
$ -0.4
|
 |
 |
Heron Therapeutics
HRTX
|
$ 1.39
|
212 M
|
$ -72.5 M
|
-10.5
|
1.4
|
$ -0.1
|
 |
 |
Verastem
VSTM
|
$ 9.33
|
206 M
|
$ -109 M
|
-2.9
|
8.1
|
$ -3.3
|
 |
 |
Editas Medicine
EDIT
|
$ 2.46
|
203 M
|
$ -242 M
|
-1.0
|
13.3
|
$ -2.6
|
 |
 |
Sensei Biotherapeutics
SNSE
|
$ 7.92
|
199 M
|
$ -31.2 M
|
-0.6
|
∙ |
$ -13.6
|
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 7.34
|
198 M
|
$ -56.6 M
|
-4.3
|
1.5
|
$ -1.7
|
 |
 |
Lyra Therapeutics
LYRA
|
$ 3.92
|
195 M
|
$ -72.2 M
|
-0.2
|
311.9
|
$ -18.1
|
 |
 |
Voyager Therapeutics
VYGR
|
$ 4.25
|
183 M
|
$ 95.1 M
|
-2.5
|
3.8
|
$ -1.7
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 3.94
|
173 M
|
$ -63.6 M
|
-2.4
|
∙ |
$ -1.7
|
 |
 |
C4 Therapeutics
CCCC
|
$ 2.44
|
169 M
|
$ -119 M
|
-1.6
|
4.3
|
$ -1.5
|
 |
 |
Assembly Biosciences
ASMB
|
$ 34.6
|
158 M
|
$ -63.1 M
|
-7.6
|
4.5
|
$ -4.7
|
 |
 |
Athira Pharma
ATHA
|
$ 3.86
|
149 M
|
$ -52.5 M
|
-0.4
|
∙ |
$ -9.6
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.69
|
148 M
|
$ -91.7 M
|
-2.9
|
∙ |
$ -1.0
|
 |
 |
Alector
ALEC
|
$ 1.46
|
141 M
|
$ -178 M
|
-1.0
|
4.8
|
$ -1.5
|
 |
 |
Anika Therapeutics
ANIK
|
$ 9.6
|
141 M
|
$ -6.4 M
|
-3.4
|
1.2
|
$ -2.8
|
 |
 |
vTv Therapeutics
VTVT
|
$ 35.69
|
141 M
|
$ -23.5 M
|
∙ |
26.5
|
∙ |
 |
 |
Forte Biosciences
FBRX
|
$ 21.93
|
140 M
|
$ -30.3 M
|
-2.7
|
7.6
|
$ -7.9
|
 |
 |
Atara Biotherapeutics
ATRA
|
$ 18.13
|
136 M
|
$ -27.9 M
|
37.0
|
0.8
|
$ 0.5
|
 |
 |
Compugen Ltd.
CGEN
|
$ 1.5
|
134 M
|
∙ |
∙ |
16.9
|
∙ |
 |
 |
VistaGen Therapeutics
VTGN
|
$ 4.34
|
134 M
|
$ -44.6 M
|
-2.2
|
142.1
|
$ -1.9
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 10.2
|
133 M
|
$ -14.2 M
|
-10.2
|
∙ |
$ -1.0
|
 |
 |
Cassava Sciences
SAVA
|
$ 2.82
|
131 M
|
$ -112 M
|
-1.4
|
3.3
|
$ -2.2
|
 |
 |
Coherus BioSciences
CHRS
|
$ 1.38
|
130 M
|
$ -181 M
|
0.8
|
3.6
|
$ 1.7
|
 |
 |
Shattuck Labs
STTK
|
$ 3.05
|
130 M
|
$ -76.3 M
|
-3.2
|
19.9
|
$ -1.0
|
 |
 |
Fate Therapeutics
FATE
|
$ 1.12
|
127 M
|
$ -186 M
|
-0.9
|
15.7
|
$ -1.3
|
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 3.08
|
124 M
|
$ -20.7 M
|
3.8
|
31.1
|
$ 0.8
|
 |
 |
Rezolute
RZLT
|
$ 1.62
|
123 M
|
$ -67 M
|
-2.0
|
∙ |
$ -0.9
|
 |
 |
Codexis
CDXS
|
$ 1.66
|
122 M
|
$ -63.9 M
|
-1.8
|
2.8
|
$ -0.9
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.31
|
122 M
|
$ -80.8 M
|
-3.2
|
3.2
|
$ -0.7
|
 |
 |
CASI Pharmaceuticals
CASI
|
$ 0.89
|
121 M
|
$ -27.1 M
|
-0.5
|
3.2
|
$ -1.7
|
 |
 |
Seer
SEER
|
$ 1.85
|
118 M
|
$ -96.5 M
|
-1.3
|
7.9
|
$ -1.4
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 1.74
|
117 M
|
$ -12.8 M
|
-182.0
|
2.0
|
$ -0.0
|
 |
 |
Cellectis S.A.
CLLS
|
$ 4.8
|
116 M
|
$ -106 M
|
-1.9
|
7.6
|
$ -2.4
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 1.91
|
115 M
|
$ -126 M
|
-1.1
|
10.8
|
$ -1.5
|
 |
 |
Cardiff Oncology
CRDF
|
$ 2.4
|
114 M
|
$ -53.4 M
|
-2.9
|
220.2
|
$ -0.8
|
 |
 |
Protara Therapeutics
TARA
|
$ 5.48
|
113 M
|
$ -43.3 M
|
-4.0
|
40.0
|
$ -1.4
|
 |
 |
Ovid Therapeutics
OVID
|
$ 1.57
|
111 M
|
$ -43 M
|
-4.0
|
17.3
|
$ -0.4
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 5.07
|
108 M
|
$ -79.6 M
|
4.9
|
18.4
|
$ 1.1
|
 |
 |
Champions Oncology
CSBR
|
$ 7.7
|
105 M
|
$ 1.27 M
|
-218.0
|
1.7
|
$ -0.0
|
 |
 |
ADC Therapeutics SA
ADCT
|
$ 4.24
|
105 M
|
$ -239 M
|
-1.6
|
6.2
|
$ -2.8
|
 |
 |
Adagene
ADAG
|
$ 1.74
|
97.9 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Entera Bio Ltd.
ENTX
|
$ 2.09
|
96 M
|
$ -8.21 M
|
4.3
|
420.5
|
$ 0.5
|
 |
 |
Repare Therapeutics
RPTX
|
$ 2.19
|
92.9 M
|
$ 22 M
|
-1.2
|
∙ |
$ -1.8
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 1.4
|
91.6 M
|
$ -166 M
|
-0.7
|
2.4
|
$ -2.0
|
 |
 |
Atossa Therapeutics
ATOS
|
$ 0.72
|
90.8 M
|
$ -29.7 M
|
-3.4
|
928.8
|
$ -0.2
|
 |
 |
Nkarta
NKTX
|
$ 1.84
|
90.2 M
|
$ -116 M
|
-1.3
|
781.3
|
$ -1.4
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 4.51
|
89.4 M
|
$ 448 K
|
-3.4
|
∙ |
$ -1.4
|
 |
 |
Adverum Biotechnologies
ADVM
|
$ 4.36
|
86.2 M
|
$ -141 M
|
-0.5
|
4.4
|
$ -8.2
|
 |
 |
MacroGenics
MGNX
|
$ 1.39
|
86.1 M
|
$ -145 M
|
-27.8
|
0.4
|
$ -0.0
|
 |