 |
Eli Lilly and Company
LLY
|
$ 939.47
|
843 B
|
$ 2.37 B
|
69.5
|
16.8
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 238.46
|
574 B
|
$ 9.42 B
|
23.8
|
6.3
|
$ 10.1
|
 |
 |
AbbVie
ABBV
|
$ 207.94
|
368 B
|
$ 15.1 B
|
95.7
|
6.4
|
$ 2.2
|
 |
 |
Merck & Co.
MRK
|
$ 121.42
|
304 B
|
$ 2.86 B
|
16.7
|
4.7
|
$ 7.3
|
 |
 |
Akari Therapeutics, Plc
AKTX
|
$ 3.83
|
258 B
|
$ -15.1 M
|
∙ |
∙ |
∙ |
 |
 |
Novartis AG
NVS
|
$ 154.05
|
227 B
|
$ 10.7 B
|
26.6
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 351.0
|
189 B
|
$ 12.4 B
|
26.8
|
7.2
|
$ 13.2
|
 |
 |
Gilead Sciences
GILD
|
$ 139.03
|
173 B
|
$ 9.3 B
|
23.3
|
6.1
|
$ 6.1
|
 |
 |
Pfizer
PFE
|
$ 26.92
|
153 B
|
$ 6.66 B
|
11.2
|
2.5
|
$ 2.4
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 58.62
|
119 B
|
$ 11 B
|
18.1
|
2.5
|
$ 3.3
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 436.27
|
112 B
|
$ 4.29 B
|
30.1
|
9.9
|
$ 14.8
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 748.87
|
78.3 B
|
$ 4.1 B
|
16.5
|
5.8
|
$ 46.5
|
 |
 |
Zoetis
ZTS
|
$ 117.86
|
52.3 B
|
$ 487 M
|
19.5
|
5.6
|
$ 6.2
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 322.11
|
42.2 B
|
$ -361 M
|
-164.8
|
16.6
|
$ -2.0
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 30.82
|
35.3 B
|
$ 2.81 B
|
72.0
|
2.1
|
$ 0.4
|
 |
 |
Insmed Incorporated
INSM
|
$ 154.81
|
30.8 B
|
$ -1.06 B
|
-25.2
|
82.7
|
$ -6.3
|
 |
 |
Axon Enterprise
AXON
|
$ 345.94
|
26.2 B
|
$ 89.9 M
|
90.8
|
14.4
|
$ 3.9
|
 |
 |
Biogen
BIIB
|
$ 172.97
|
25.3 B
|
$ 2.03 B
|
14.0
|
2.6
|
$ 12.7
|
 |
 |
United Therapeutics Corporation
UTHR
|
$ 571.73
|
25.3 B
|
$ 1.42 B
|
21.1
|
8.3
|
$ 27.2
|
 |
 |
argenx SE
ARGX
|
$ 799.65
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Zai Lab Limited
ZLAB
|
$ 20.68
|
22.7 B
|
$ -218 M
|
-138.3
|
52.2
|
$ -0.2
|
 |
 |
Royalty Pharma plc
RPRX
|
$ 47.9
|
20.6 B
|
$ 1.1 B
|
19.2
|
8.9
|
$ 2.5
|
 |
 |
Longeveron
LGVN
|
$ 1.16
|
20.4 B
|
$ -21.7 M
|
-0.8
|
12359.4
|
$ -1.4
|
 |
 |
Moderna
MRNA
|
$ 50.96
|
19.8 B
|
$ -2.09 B
|
-10.0
|
6.4
|
$ -5.1
|
 |
 |
Incyte Corporation
INCY
|
$ 96.07
|
18.8 B
|
$ 573 M
|
68.3
|
4.2
|
$ 1.4
|
 |
 |
Revolution Medicines
RVMD
|
$ 96.43
|
18.3 B
|
$ -989 M
|
-19.3
|
784.8
|
$ -5.0
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 77.5
|
14.7 B
|
$ -373 M
|
-0.1
|
150.4
|
$ -791.5
|
 |
 |
Summit Therapeutics
SMMT
|
$ 19.67
|
14.7 B
|
$ -609 M
|
-15.6
|
7168.9
|
$ -1.2
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 74.59
|
14.3 B
|
$ -603 M
|
-24.5
|
62.3
|
$ -3.1
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 15.24
|
13.1 B
|
$ -59 M
|
-303.2
|
124.5
|
$ -0.0
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 128.89
|
12.8 B
|
$ 124 M
|
42.6
|
5.3
|
$ 3.1
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 75.17
|
12 B
|
$ -451 M
|
-49.3
|
13.0
|
$ -1.6
|
 |
 |
Exelixis
EXEL
|
$ 44.27
|
12 B
|
$ 363 M
|
19.1
|
5.4
|
$ 2.4
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 194.2
|
11.8 B
|
$ 73.8 M
|
-35.3
|
2.9
|
$ -5.6
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 519.61
|
11.7 B
|
$ -389 M
|
-34.4
|
16.8
|
$ -15.2
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 54.53
|
10.5 B
|
$ 790 M
|
16.9
|
3.6
|
$ 3.3
|
 |
 |
Mesoblast Limited
MESO
|
$ 15.0
|
9.73 B
|
∙ |
-1.9
|
953.4
|
$ -7.6
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 178.11
|
8.86 B
|
$ -197 M
|
-40.0
|
16.3
|
$ -4.5
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 55.54
|
8.75 B
|
$ 276 M
|
65.4
|
7.3
|
$ 0.8
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 65.14
|
8.71 B
|
$ -441 M
|
-17.4
|
29.7
|
$ -3.8
|
 |
 |
Vaxcyte
PCVX
|
$ 60.88
|
8.29 B
|
$ -581 M
|
-13.3
|
∙ |
$ -4.6
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 67.82
|
8.13 B
|
$ 736 M
|
13.7
|
6.5
|
$ 4.9
|
 |
 |
Krystal Biotech
KRYS
|
$ 259.0
|
7.5 B
|
$ 145 M
|
41.3
|
20.4
|
$ 6.3
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 85.05
|
7.19 B
|
$ -316 M
|
-24.8
|
184.1
|
$ -3.5
|
 |
 |
Praxis Precision Medicines
PRAX
|
$ 316.14
|
7.11 B
|
$ -198 M
|
-25.2
|
4625.7
|
$ -12.7
|
 |
 |
Can-Fite BioPharma Ltd.
CANF
|
$ 2.92
|
6.35 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Protagonist Therapeutics
PTGX
|
$ 98.82
|
6.28 B
|
$ 120 M
|
-54.8
|
153.0
|
$ -1.9
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 14.48
|
6.01 B
|
$ -48.8 M
|
-98.5
|
27.3
|
$ -0.2
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 49.96
|
5.73 B
|
$ -216 M
|
-15.3
|
53.7
|
$ -3.2
|
 |
 |
Alkermes plc
ALKS
|
$ 33.36
|
5.49 B
|
$ 287 M
|
19.6
|
3.9
|
$ 1.8
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 84.39
|
5.48 B
|
$ -189 M
|
-27.7
|
33.8
|
$ -3.1
|
 |
 |
PTC Therapeutics
PTCT
|
$ 68.69
|
5.46 B
|
$ 906 M
|
7.8
|
3.2
|
$ 9.1
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 40.79
|
5.15 B
|
$ -471 M
|
-22.2
|
6.9
|
$ -1.8
|
 |
 |
TG Therapeutics
TGTX
|
$ 33.73
|
4.87 B
|
$ -72.3 M
|
11.8
|
9.8
|
$ 2.9
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 95.2
|
4.78 B
|
$ -6.4 M
|
-149.9
|
10.7
|
$ -0.7
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 51.22
|
4.61 B
|
$ -601 M
|
-8.4
|
1431.9
|
$ -6.2
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 58.4
|
4.55 B
|
$ -216 M
|
-15.2
|
269.5
|
$ -3.9
|
 |
 |
Amicus Therapeutics
FOLD
|
$ 14.46
|
4.46 B
|
$ 46.2 M
|
-131.6
|
7.6
|
$ -0.1
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 41.91
|
4.35 B
|
$ 80.9 M
|
36.4
|
5.9
|
$ 1.2
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 12.54
|
3.93 B
|
$ 545 M
|
91.4
|
1.4
|
$ 0.1
|
 |
 |
Viking Therapeutics
VKTX
|
$ 34.26
|
3.86 B
|
$ -201 M
|
-24.8
|
∙ |
$ -1.4
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 204.92
|
3.75 B
|
$ 60.8 M
|
56.5
|
14.4
|
$ 3.6
|
 |
 |
Immunovant
IMVT
|
$ 24.5
|
3.71 B
|
$ 324 K
|
-9.1
|
∙ |
$ -2.8
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 39.44
|
3.71 B
|
$ -274 M
|
-8.6
|
1927.3
|
$ -4.6
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 21.74
|
3.6 B
|
$ -213 M
|
-15.6
|
7.5
|
$ -1.4
|
 |
 |
Inhibrx
INBX
|
$ 75.27
|
3.55 B
|
$ -160 M
|
-18.0
|
8040.8
|
$ -4.2
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 47.08
|
3.49 B
|
$ 24.2 M
|
394.4
|
6.8
|
$ 0.1
|
 |
 |
Liquidia Corporation
LQDA
|
$ 38.55
|
3.32 B
|
$ -99.1 M
|
-29.2
|
49.0
|
$ -1.4
|
 |
 |
Denali Therapeutics
DNLI
|
$ 19.23
|
3.16 B
|
$ -471 M
|
-6.7
|
9.5
|
$ -2.9
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 24.21
|
3.08 B
|
$ -142 M
|
-22.8
|
14.0
|
$ -1.1
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 24.94
|
3.05 B
|
$ 152 M
|
15.1
|
5.5
|
$ 1.7
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 72.56
|
3.03 B
|
$ -87.3 M
|
-35.7
|
8.7
|
$ -2.0
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 20.59
|
2.87 B
|
$ -83 M
|
-17.4
|
671.1
|
$ -1.2
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 50.68
|
2.86 B
|
$ 4.48 M
|
572.2
|
4.3
|
$ 0.1
|
 |
 |
Beam Therapeutics
BEAM
|
$ 27.43
|
2.71 B
|
$ -451 M
|
-5.8
|
65.3
|
$ -4.5
|
 |
 |
IDEAYA Biosciences
IDYA
|
$ 30.5
|
2.7 B
|
$ -129 M
|
-32.6
|
12.1
|
$ -1.0
|
 |
 |
Veracyte
VCYT
|
$ 31.09
|
2.44 B
|
$ 48.4 M
|
60.3
|
5.0
|
$ 0.5
|
 |
 |
Arcus Biosciences
RCUS
|
$ 22.34
|
2.4 B
|
$ -281 M
|
-7.2
|
9.1
|
$ -3.2
|
 |
 |
ADMA Biologics
ADMA
|
$ 9.7
|
2.31 B
|
$ 176 M
|
18.1
|
4.8
|
$ 0.6
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 23.3
|
2.3 B
|
$ -664 M
|
-4.0
|
6.8
|
$ -6.0
|
 |
 |
Kodiak Sciences
KOD
|
$ 43.11
|
2.29 B
|
$ -244 M
|
-10.3
|
∙ |
$ -4.1
|
 |
 |
Celldex Therapeutics
CLDX
|
$ 32.24
|
2.14 B
|
$ -159 M
|
-10.2
|
313.9
|
$ -3.3
|
 |
 |
Relay Therapeutics
RLAY
|
$ 14.94
|
2.13 B
|
$ -356 M
|
-7.8
|
49.2
|
$ -1.9
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 21.18
|
2.12 B
|
$ -254 M
|
-5.5
|
1.0
|
$ -4.0
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 15.76
|
2.12 B
|
$ 60.9 M
|
31.3
|
8.0
|
$ 0.5
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 24.44
|
2.09 B
|
$ -130 M
|
-7.1
|
18.2
|
$ -3.5
|
 |
 |
Stoke Therapeutics
STOK
|
$ 34.33
|
2.03 B
|
$ 33.6 M
|
81.7
|
11.1
|
$ 0.4
|
 |
 |
AnaptysBio
ANAB
|
$ 70.1
|
2.02 B
|
$ -143 M
|
-21.3
|
12.6
|
$ -3.2
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 9.56
|
1.98 B
|
$ -37 M
|
-197.8
|
3.5
|
$ -0.0
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 12.79
|
1.94 B
|
$ -60.1 M
|
-25.3
|
8.1
|
$ -0.5
|
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 32.92
|
1.91 B
|
$ -381 M
|
2.9
|
49.2
|
$ 11.5
|
 |
 |
Immunome
IMNM
|
$ 21.69
|
1.89 B
|
$ -154 M
|
-8.9
|
190.1
|
$ -2.5
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 13.19
|
1.78 B
|
$ -39.2 M
|
-34.1
|
∙ |
$ -0.4
|
 |
 |
Avidity Biosciences
RNA
|
$ 12.71
|
1.75 B
|
$ -586 M
|
-3.4
|
93.4
|
$ -4.0
|
 |
 |
Vericel Corporation
VCEL
|
$ 33.7
|
1.7 B
|
$ -4.45 M
|
-209.9
|
7.0
|
$ -0.2
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 28.89
|
1.66 B
|
$ 250 M
|
9.2
|
2.1
|
$ 3.2
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 8.79
|
1.65 B
|
$ -136 M
|
-6.8
|
32.2
|
$ -1.4
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 18.17
|
1.62 B
|
$ 16.5 M
|
159.2
|
16.3
|
$ 0.1
|
 |
 |
Innoviva
INVA
|
$ 23.76
|
1.6 B
|
$ 194 M
|
15.2
|
4.2
|
$ 1.6
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 14.95
|
1.52 B
|
$ -251 M
|
-3.8
|
22.1
|
$ -4.0
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 78.36
|
1.51 B
|
$ 140 M
|
81.0
|
2.0
|
$ 1.0
|
 |
 |
Ardelyx
ARDX
|
$ 6.18
|
1.49 B
|
$ -107 M
|
-14.3
|
4.3
|
$ -0.4
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 31.2
|
1.45 B
|
$ -90.2 M
|
-15.6
|
84.8
|
$ -2.0
|
 |
 |
Taysha Gene Therapies
TSHA
|
$ 4.49
|
1.44 B
|
$ -107 M
|
-12.9
|
205.9
|
$ -0.4
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 16.1
|
1.4 B
|
$ -121 M
|
-8.5
|
∙ |
$ -2.0
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 16.03
|
1.39 B
|
$ -235 M
|
-5.4
|
18.3
|
$ -3.0
|
 |
 |
Zymeworks
ZYME
|
$ 26.32
|
1.36 B
|
$ -268 M
|
-5.9
|
161.6
|
$ -4.6
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 13.49
|
1.33 B
|
$ -477 M
|
-3.2
|
25.4
|
$ -4.3
|
 |
 |
Vir Biotechnology
VIR
|
$ 9.5
|
1.32 B
|
$ -669 M
|
-2.2
|
197.1
|
$ -4.6
|
 |
 |
Novavax
NVAX
|
$ 8.12
|
1.32 B
|
$ -17.9 M
|
4.6
|
1.3
|
$ 1.9
|
 |
 |
Precigen
PGEN
|
$ 4.16
|
1.3 B
|
$ 14.9 M
|
-3.0
|
57.5
|
$ -1.4
|
 |
 |
Savara
SVRA
|
$ 5.66
|
1.26 B
|
$ -116 M
|
-11.5
|
1642.0
|
$ -0.5
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 7.18
|
1.21 B
|
$ -145 M
|
-5.2
|
24.1
|
$ -1.4
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 35.47
|
1.12 B
|
$ 158 M
|
20.1
|
1.5
|
$ 1.8
|
 |
 |
Geron Corporation
GERN
|
$ 1.67
|
1.11 B
|
$ -152 M
|
-14.7
|
7.2
|
$ -0.1
|
 |
 |
Seres Therapeutics
MCRB
|
$ 8.32
|
1.06 B
|
$ -99.2 M
|
0.6
|
8.8
|
$ 14.1
|
 |
 |
AbCellera Biologics
ABCL
|
$ 3.54
|
1.06 B
|
$ -229 M
|
-5.5
|
27.9
|
$ -0.6
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 19.39
|
1.04 B
|
$ -159 M
|
-5.3
|
24.5
|
$ -3.8
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 21.57
|
1.04 B
|
$ -112 M
|
-6.7
|
10.0
|
$ -3.1
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 20.37
|
952 M
|
$ 211 M
|
8.7
|
1.3
|
$ 2.4
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 5.85
|
938 M
|
$ 3.68 M
|
-21.5
|
3.7
|
$ -0.3
|
 |
 |
Xencor
XNCR
|
$ 12.42
|
922 M
|
$ -169 M
|
-6.7
|
8.1
|
$ -1.9
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 12.63
|
921 M
|
$ -296 M
|
-2.4
|
10.0
|
$ -5.2
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 2.29
|
908 M
|
$ -24.3 M
|
-17.5
|
∙ |
$ -0.1
|
 |
 |
Annexon
ANNX
|
$ 5.85
|
907 M
|
$ -180 M
|
-5.2
|
∙ |
$ -1.2
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 10.15
|
891 M
|
$ -112 M
|
-6.1
|
∙ |
$ -1.7
|
 |
 |
Certara
CERT
|
$ 5.55
|
890 M
|
$ 65.2 M
|
270.5
|
2.1
|
$ 0.0
|
 |
 |
uniQure N.V.
QURE
|
$ 15.38
|
884 M
|
$ -211 M
|
-4.3
|
73.1
|
$ -3.8
|
 |
 |
Cullinan Management
CGEM
|
$ 14.54
|
876 M
|
$ -190 M
|
-4.7
|
48.4
|
$ -3.2
|
 |
 |
Theravance Biopharma
TBPH
|
$ 16.35
|
823 M
|
$ -131 M
|
29.6
|
10.8
|
$ 0.6
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.15
|
795 M
|
$ -78.1 M
|
-16.5
|
57.3
|
$ -0.3
|
 |
 |
MannKind Corporation
MNKD
|
$ 2.57
|
785 M
|
$ 67.5 M
|
25.6
|
2.6
|
$ 0.1
|
 |
 |
Sana Biotechnology
SANA
|
$ 3.09
|
782 M
|
$ -237 M
|
-3.1
|
∙ |
$ -1.0
|
 |
 |
Arvinas
ARVN
|
$ 10.82
|
767 M
|
$ -101 M
|
-13.0
|
2.2
|
$ -0.9
|
 |
 |
Kura Oncology
KURA
|
$ 8.67
|
760 M
|
$ -118 M
|
-3.1
|
15.5
|
$ -2.9
|
 |
 |
Omeros Corporation
OMER
|
$ 11.49
|
730 M
|
$ -128 M
|
-5.8
|
8.4
|
$ -2.0
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 15.1
|
725 M
|
$ -37.9 M
|
-25.7
|
∙ |
$ -0.6
|
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 8.97
|
721 M
|
$ -160 M
|
-4.3
|
49.1
|
$ -2.2
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 26.36
|
709 M
|
$ -2.42 M
|
-129.0
|
10.6
|
$ -0.2
|
 |
 |
Burford Capital Limited
BUR
|
$ 4.36
|
708 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.72
|
624 M
|
$ -124 M
|
-6.3
|
13.9
|
$ -0.3
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 4.39
|
606 M
|
$ -53.6 M
|
60.6
|
7.0
|
$ 0.1
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 2.72
|
600 M
|
$ -295 M
|
-2.8
|
6687.6
|
$ -1.0
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 9.17
|
593 M
|
$ -651 M
|
-0.6
|
1.0
|
$ -15.0
|
 |
 |
Tenax Therapeutics
TENX
|
$ 14.43
|
566 M
|
$ 1.23 M
|
-13.1
|
1561.7
|
$ -1.1
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 10.5
|
565 M
|
$ -256 M
|
-2.0
|
53.5
|
$ -5.2
|
 |
 |
Ocugen
OCGN
|
$ 1.76
|
550 M
|
$ -74.6 M
|
-7.5
|
101.7
|
$ -0.2
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 29.2
|
525 M
|
$ 119 M
|
4.9
|
2.0
|
$ 6.2
|
 |
 |
SELLAS Life Sciences Group
SLS
|
$ 4.76
|
519 M
|
$ -39.5 M
|
-16.8
|
46.0
|
$ -0.3
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 4.04
|
495 M
|
$ -63.6 M
|
-8.5
|
46.0
|
$ -0.5
|
 |
 |
Shattuck Labs
STTK
|
$ 6.92
|
482 M
|
$ -76.3 M
|
-7.6
|
76.6
|
$ -1.0
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 6.61
|
475 M
|
$ -166 M
|
-2.2
|
8.2
|
$ -2.0
|
 |
 |
Benitec Biopharma
BNTC
|
$ 11.42
|
470 M
|
$ -44.1 M
|
-11.2
|
3486.0
|
$ -1.0
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 5.67
|
462 M
|
$ -166 M
|
-3.4
|
3.0
|
$ -1.7
|
 |
 |
Forte Biosciences
FBRX
|
$ 35.09
|
454 M
|
$ -30.3 M
|
-4.3
|
24.3
|
$ -7.9
|
 |
 |
REGENXBIO
RGNX
|
$ 8.8
|
454 M
|
$ -246 M
|
-1.9
|
4.7
|
$ -4.8
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 2.17
|
451 M
|
$ -164 M
|
-3.8
|
1.6
|
$ -0.6
|
 |
 |
XOMA Corporation
XOMA
|
$ 36.74
|
444 M
|
$ 5.72 M
|
-111.4
|
9.7
|
$ -0.3
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 2.37
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
Aquestive Therapeutics
AQST
|
$ 4.08
|
436 M
|
$ -30.5 M
|
-9.5
|
7.9
|
$ -0.4
|
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 0.83
|
428 M
|
$ -59.3 M
|
4.4
|
9.2
|
$ 0.2
|
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 7.22
|
425 M
|
$ -95.2 M
|
-6.5
|
2.2
|
$ -1.1
|
 |
 |
Keros Therapeutics
KROS
|
$ 11.21
|
417 M
|
$ 38 M
|
9.5
|
1.9
|
$ 1.3
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 56.08
|
416 M
|
$ -12.1 M
|
-36.7
|
∙ |
$ -1.6
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 3.07
|
405 M
|
$ -264 M
|
-2.6
|
1.8
|
$ -1.2
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 4.85
|
403 M
|
$ -63.6 M
|
-3.0
|
∙ |
$ -1.7
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 11.12
|
403 M
|
$ -31.2 M
|
-7.6
|
13478.7
|
$ -1.5
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.49
|
397 M
|
$ -258 M
|
-1.4
|
∙ |
$ -1.0
|
 |
 |
Puma Biotechnology
PBYI
|
$ 7.78
|
389 M
|
$ 45.4 M
|
10.1
|
1.7
|
$ 0.8
|
 |
 |
Replimune Group
REPL
|
$ 4.76
|
383 M
|
$ -309 M
|
-1.7
|
∙ |
$ -3.4
|
 |
 |
Plus Therapeutics
PSTV
|
$ 4.8
|
373 M
|
$ -15.7 M
|
-2.0
|
56.4
|
$ -2.0
|
 |
 |
Verastem
VSTM
|
$ 5.31
|
368 M
|
$ -109 M
|
-1.7
|
14.9
|
$ -3.3
|
 |
 |
Cerus Corporation
CERS
|
$ 1.89
|
360 M
|
$ -31.5 M
|
-15.9
|
7.1
|
$ -0.1
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.4
|
360 M
|
$ -3.97 M
|
-7.0
|
1.7
|
$ -0.2
|
 |
 |
Ovid Therapeutics
OVID
|
$ 2.75
|
358 M
|
$ -43 M
|
-7.0
|
55.9
|
$ -0.4
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 4.94
|
342 M
|
$ -260 M
|
-1.4
|
13.8
|
$ -3.5
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.48
|
341 M
|
$ -33.3 M
|
-5.0
|
29.2
|
$ -0.3
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 25.78
|
336 M
|
$ -14.2 M
|
-24.6
|
∙ |
$ -1.0
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 3.49
|
331 M
|
$ -251 M
|
-1.5
|
∙ |
$ -2.3
|
 |
 |
Assembly Biosciences
ASMB
|
$ 28.42
|
319 M
|
$ -63.1 M
|
-6.3
|
9.1
|
$ -4.7
|
 |
 |
Cabaletta Bio
CABA
|
$ 3.13
|
315 M
|
$ -67.8 M
|
-1.4
|
∙ |
$ -2.4
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 4.08
|
314 M
|
$ -126 M
|
-2.9
|
35.6
|
$ -1.5
|
 |
 |
SIGA Technologies
SIGA
|
$ 4.36
|
312 M
|
$ 50.6 M
|
10.5
|
3.1
|
$ 0.4
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 4.59
|
289 M
|
$ -83 M
|
-4.2
|
10.2
|
$ -1.1
|
 |
 |
Altimmune
ALT
|
$ 3.24
|
285 M
|
$ -95.3 M
|
-3.2
|
14889.6
|
$ -1.1
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 5.99
|
281 M
|
$ -22.5 M
|
-9.1
|
580.7
|
$ -0.7
|
 |
 |
Rezolute
RZLT
|
$ 3.64
|
277 M
|
$ -67 M
|
-4.1
|
∙ |
$ -0.9
|
 |
 |
BioAtla
BCAB
|
$ 4.46
|
262 M
|
$ -95.6 M
|
-4.2
|
443.2
|
$ -1.1
|
 |
 |
Editas Medicine
EDIT
|
$ 2.94
|
261 M
|
$ -242 M
|
-1.1
|
16.2
|
$ -2.6
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 4.08
|
260 M
|
$ -22.2 M
|
-3.4
|
849.9
|
$ -1.3
|
 |
 |
Kamada Ltd.
KMDA
|
$ 8.49
|
260 M
|
$ 6.96 M
|
65.5
|
4.5
|
$ 0.1
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 4.91
|
260 M
|
$ -79.6 M
|
4.6
|
43.4
|
$ 1.1
|
 |
 |
Alector
ALEC
|
$ 2.45
|
252 M
|
$ -178 M
|
-1.6
|
8.2
|
$ -1.5
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 2.95
|
252 M
|
$ -51.1 M
|
-6.2
|
∙ |
$ -0.5
|
 |
 |
Compugen Ltd.
CGEN
|
$ 2.58
|
241 M
|
∙ |
∙ |
29.0
|
∙ |
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 8.36
|
229 M
|
$ -56.6 M
|
-4.8
|
1.6
|
$ -1.7
|
 |
 |
MacroGenics
MGNX
|
$ 3.6
|
227 M
|
$ -145 M
|
-68.8
|
1.0
|
$ -0.0
|
 |
 |
Sutro Biopharma
STRO
|
$ 25.86
|
220 M
|
$ -179 M
|
-11.6
|
2.3
|
$ -2.3
|
 |
 |
Voyager Therapeutics
VYGR
|
$ 3.74
|
220 M
|
$ 95.1 M
|
-2.3
|
4.7
|
$ -1.7
|
 |
 |
Anika Therapeutics
ANIK
|
$ 14.76
|
216 M
|
$ -6.4 M
|
-5.4
|
2.0
|
$ -2.8
|
 |
 |
Milestone Pharmaceuticals
MIST
|
$ 2.02
|
215 M
|
$ -61.4 M
|
-2.6
|
∙ |
$ -0.8
|
 |
 |
Adagene
ADAG
|
$ 3.8
|
214 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Protara Therapeutics
TARA
|
$ 4.96
|
212 M
|
$ -43.3 M
|
-3.7
|
77.2
|
$ -1.4
|
 |
 |
C4 Therapeutics
CCCC
|
$ 2.54
|
211 M
|
$ -119 M
|
-1.8
|
5.8
|
$ -1.5
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 74.86
|
209 M
|
$ -28.2 M
|
56.3
|
20.3
|
$ 1.3
|
 |
 |
Coherus BioSciences
CHRS
|
$ 1.68
|
197 M
|
$ -181 M
|
1.0
|
5.4
|
$ 1.7
|
 |
 |
Codexis
CDXS
|
$ 2.24
|
195 M
|
$ -63.9 M
|
-2.6
|
4.7
|
$ -0.9
|
 |
 |
Immunic
IMUX
|
$ 1.17
|
182 M
|
$ -105 M
|
-1.6
|
∙ |
$ -0.8
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 2.3
|
181 M
|
$ -12.8 M
|
-228.0
|
2.9
|
$ -0.0
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 4.1
|
173 M
|
$ -9.29 M
|
-0.4
|
36.1
|
$ -9.6
|
 |
 |
Inhibikase Therapeutics
IKT
|
$ 1.7
|
167 M
|
$ -44 M
|
-1.6
|
620.4
|
$ -1.0
|
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 5.81
|
166 M
|
$ -20.6 M
|
-16.8
|
4.8
|
$ -0.4
|
 |
 |
Nkarta
NKTX
|
$ 2.17
|
161 M
|
$ -116 M
|
-1.6
|
1475.9
|
$ -1.4
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 3.49
|
152 M
|
$ 448 K
|
-2.4
|
∙ |
$ -1.4
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.67
|
150 M
|
$ -80.8 M
|
-3.8
|
4.0
|
$ -0.7
|
 |
 |
Fate Therapeutics
FATE
|
$ 1.24
|
147 M
|
$ -186 M
|
-1.0
|
18.1
|
$ -1.3
|
 |
 |
Galectin Therapeutics
GALT
|
$ 2.3
|
147 M
|
$ -36 M
|
-4.2
|
-398.2
|
$ -0.6
|
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 3.53
|
146 M
|
$ -20.7 M
|
4.4
|
36.2
|
$ 0.8
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.56
|
146 M
|
$ -91.7 M
|
-2.6
|
∙ |
$ -1.0
|
 |
 |
vTv Therapeutics
VTVT
|
$ 36.56
|
144 M
|
$ -23.5 M
|
∙ |
29.3
|
∙ |
 |
 |
Heron Therapeutics
HRTX
|
$ 0.85
|
142 M
|
$ -72.5 M
|
-6.3
|
0.9
|
$ -0.1
|
 |
 |
Corbus Pharmaceuticals Holdings
CRBP
|
$ 9.8
|
131 M
|
$ -78.4 M
|
-1.8
|
65.1
|
$ -5.9
|
 |
 |
Agenus
AGEN
|
$ 3.96
|
118 M
|
$ -128 M
|
-1.4
|
1.3
|
$ -3.1
|
 |
 |
Cellectis S.A.
CLLS
|
$ 3.59
|
116 M
|
$ -106 M
|
-1.4
|
7.6
|
$ -2.4
|
 |
 |
Seer
SEER
|
$ 1.69
|
108 M
|
$ -96.5 M
|
-1.2
|
7.5
|
$ -1.4
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 1.78
|
107 M
|
$ -51 M
|
-2.2
|
∙ |
$ -0.7
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 12.48
|
106 M
|
$ -91.1 M
|
-0.4
|
10.5
|
$ -33.0
|
 |
 |
Cardiff Oncology
CRDF
|
$ 1.58
|
106 M
|
$ -53.4 M
|
-2.0
|
216.8
|
$ -0.8
|
 |
 |
ADC Therapeutics SA
ADCT
|
$ 3.74
|
105 M
|
$ -239 M
|
-1.4
|
6.2
|
$ -2.8
|
 |
 |
Equillium
EQ
|
$ 1.8
|
103 M
|
$ -28.8 M
|
-4.2
|
2.4
|
$ -0.4
|
 |
 |
Gossamer Bio
GOSS
|
$ 0.41
|
93.7 M
|
$ -59.8 M
|
-0.5
|
1.9
|
$ -0.7
|
 |
 |
ALX Oncology Holdings
ALXO
|
$ 1.7
|
91.2 M
|
$ -113 M
|
-0.8
|
25.2
|
$ -2.1
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 8.0
|
79.1 M
|
$ -85.3 M
|
-3.2
|
24.0
|
$ -2.5
|
 |
 |
Pliant Therapeutics
PLRX
|
$ 1.28
|
78.5 M
|
$ -193 M
|
-0.4
|
10.3
|
$ -3.0
|
 |
 |
Champions Oncology
CSBR
|
$ 5.75
|
78.5 M
|
$ 5.92 M
|
17.4
|
1.3
|
$ 0.3
|
 |
 |
MediciNova
MNOV
|
$ 1.49
|
73.1 M
|
$ -13.2 M
|
-5.7
|
53.8
|
$ -0.2
|
 |
 |
BeyondSpring
BYSI
|
$ 1.74
|
71.6 M
|
$ -71 M
|
∙ |
∙ |
∙ |
 |
 |
Tiziana Life Sciences PLC
TLSA
|
$ 1.18
|
71.5 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
XBiotech
XBIT
|
$ 2.33
|
71 M
|
$ -34.4 M
|
-3.0
|
8.6
|
$ -0.8
|
 |
 |
PolyPid Ltd.
PYPD
|
$ 4.31
|
70.5 M
|
$ -17.9 M
|
0.2
|
∙ |
$ 25.9
|
 |
 |
Sangamo Therapeutics
SGMO
|
$ 0.25
|
70 M
|
$ -113 M
|
-0.8
|
1.1
|
$ -0.3
|
 |
 |
PMV Pharmaceuticals
PMVP
|
$ 1.32
|
69.4 M
|
$ -88.4 M
|
-0.9
|
∙ |
$ -1.5
|
 |
 |
Fortress Biotech
FBIO
|
$ 2.35
|
65.6 M
|
$ -87.3 M
|
-3.9
|
1.1
|
$ -0.6
|
 |
 |
ImmuCell Corporation
ICCC
|
$ 7.08
|
63.9 M
|
$ 3.86 M
|
65.4
|
2.5
|
$ 0.1
|
 |
 |
Entera Bio Ltd.
ENTX
|
$ 1.15
|
62.6 M
|
$ -8.21 M
|
2.3
|
266.5
|
$ 0.5
|
 |
 |
Atara Biotherapeutics
ATRA
|
$ 4.65
|
58.3 M
|
$ -27.9 M
|
10.1
|
0.4
|
$ 0.5
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 5.11
|
54.4 M
|
$ -25.5 M
|
-1.2
|
2.2
|
$ -5.0
|
 |
 |
Kezar Life Sciences
KZR
|
$ 7.37
|
53.9 M
|
$ -64.9 M
|
-0.9
|
7.7
|
$ -8.4
|
 |
 |
PDS Biotechnology Corporation
PDSB
|
$ 1.08
|
50.1 M
|
$ -35.9 M
|
-1.2
|
∙ |
$ -0.9
|
 |
 |
Spruce Biosciences
SPRB
|
$ 63.63
|
48.8 M
|
$ -51.8 M
|
-1.9
|
6.9
|
$ -34.2
|
 |