 |
Eli Lilly and Company
LLY
|
$ 1 037.38
|
934 B
|
$ 2.37 B
|
75.6
|
18.3
|
$ 13.7
|
 |
 |
Johnson & Johnson
JNJ
|
$ 217.95
|
525 B
|
$ 9.42 B
|
21.6
|
5.7
|
$ 10.1
|
 |
 |
AbbVie
ABBV
|
$ 213.61
|
378 B
|
$ 15.1 B
|
96.6
|
6.4
|
$ 2.2
|
 |
 |
Merck & Co.
MRK
|
$ 108.82
|
276 B
|
$ 2.86 B
|
14.8
|
4.2
|
$ 7.3
|
 |
 |
Novartis AG
NVS
|
$ 144.59
|
227 B
|
$ 10.7 B
|
24.8
|
∙ |
$ 5.8
|
 |
 |
Amgen
AMGN
|
$ 329.18
|
177 B
|
$ 12.4 B
|
24.9
|
6.7
|
$ 13.2
|
 |
 |
Gilead Sciences
GILD
|
$ 125.59
|
157 B
|
$ 9.3 B
|
20.5
|
5.4
|
$ 6.1
|
 |
 |
Pfizer
PFE
|
$ 25.61
|
145 B
|
$ 6.66 B
|
10.5
|
2.3
|
$ 2.4
|
 |
 |
Vertex Pharmaceuticals Incorporated
VRTX
|
$ 440.02
|
113 B
|
$ 4.29 B
|
29.8
|
9.8
|
$ 14.8
|
 |
 |
Bristol-Myers Squibb Company
BMY
|
$ 54.61
|
111 B
|
$ 11 B
|
16.8
|
2.4
|
$ 3.3
|
 |
 |
AstraZeneca PLC
AZN
|
$ 90.47
|
96.9 B
|
$ 3.67 B
|
69.4
|
3.8
|
$ 1.4
|
 |
 |
Regeneron Pharmaceuticals
REGN
|
$ 736.17
|
79.4 B
|
$ 4.1 B
|
15.8
|
5.7
|
$ 46.5
|
 |
 |
Zoetis
ZTS
|
$ 124.19
|
56.4 B
|
$ 487 M
|
20.2
|
6.0
|
$ 6.2
|
 |
 |
Axon Enterprise
AXON
|
$ 628.47
|
47.6 B
|
$ 89.9 M
|
164.4
|
26.0
|
$ 3.9
|
 |
 |
Alnylam Pharmaceuticals
ALNY
|
$ 351.78
|
44.9 B
|
$ -361 M
|
-184.1
|
18.1
|
$ -2.0
|
 |
 |
Teva Pharmaceutical Industries Limited
TEVA
|
$ 31.66
|
35.8 B
|
$ 2.81 B
|
73.9
|
2.1
|
$ 0.4
|
 |
 |
Insmed Incorporated
INSM
|
$ 163.34
|
26.8 B
|
$ -1.06 B
|
-25.5
|
69.0
|
$ -6.3
|
 |
 |
argenx SE
ARGX
|
$ 803.87
|
25 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Biogen
BIIB
|
$ 164.72
|
24 B
|
$ 2.03 B
|
13.0
|
2.4
|
$ 12.7
|
 |
 |
Incyte Corporation
INCY
|
$ 102.6
|
21.2 B
|
$ 573 M
|
74.8
|
4.9
|
$ 1.4
|
 |
 |
United Therapeutics Corporation
UTHR
|
$ 467.8
|
21.1 B
|
$ 1.42 B
|
17.1
|
6.9
|
$ 27.2
|
 |
 |
Revolution Medicines
RVMD
|
$ 115.03
|
19.3 B
|
$ -989 M
|
-24.1
|
865.5
|
$ -5.0
|
 |
 |
Legend Biotech Corporation
LEGN
|
$ 23.49
|
18.7 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Zai Lab Limited
ZLAB
|
$ 18.84
|
18.6 B
|
$ -218 M
|
-123.9
|
42.3
|
$ -0.2
|
 |
 |
Royalty Pharma plc
RPRX
|
$ 39.34
|
17.6 B
|
$ 1.1 B
|
15.8
|
7.6
|
$ 2.5
|
 |
 |
Moderna
MRNA
|
$ 42.05
|
16.1 B
|
$ -2.09 B
|
-8.2
|
5.1
|
$ -5.1
|
 |
 |
BridgeBio Pharma
BBIO
|
$ 76.36
|
14.2 B
|
$ -603 M
|
-24.8
|
61.1
|
$ -3.1
|
 |
 |
Hutchison China MediTech Limited
HCM
|
$ 15.68
|
13.4 B
|
$ -59 M
|
-321.0
|
131.4
|
$ -0.0
|
 |
 |
Neurocrine Biosciences
NBIX
|
$ 133.47
|
13.4 B
|
$ 124 M
|
42.8
|
5.4
|
$ 3.1
|
 |
 |
Exelixis
EXEL
|
$ 43.83
|
12.7 B
|
$ 363 M
|
18.5
|
5.6
|
$ 2.4
|
 |
 |
Summit Therapeutics
SMMT
|
$ 16.18
|
11.6 B
|
$ -609 M
|
-13.7
|
6079.4
|
$ -1.2
|
 |
 |
Ionis Pharmaceuticals
IONS
|
$ 76.77
|
11.5 B
|
$ -451 M
|
-49.2
|
12.1
|
$ -1.6
|
 |
 |
Bio-Techne Corporation
TECH
|
$ 69.56
|
11 B
|
$ 292 M
|
83.7
|
9.1
|
$ 0.8
|
 |
 |
Mesoblast Limited
MESO
|
$ 16.8
|
10.9 B
|
∙ |
-2.3
|
1143.4
|
$ -7.6
|
 |
 |
Madrigal Pharmaceuticals
MDGL
|
$ 504.75
|
10.7 B
|
$ -389 M
|
-33.0
|
15.3
|
$ -15.2
|
 |
 |
BioMarin Pharmaceutical
BMRN
|
$ 56.0
|
10.6 B
|
$ 790 M
|
16.3
|
3.4
|
$ 3.3
|
 |
 |
Jazz Pharmaceuticals plc
JAZZ
|
$ 166.07
|
10.3 B
|
$ 73.8 M
|
-30.1
|
2.5
|
$ -5.6
|
 |
 |
Pulmatrix
PULM
|
$ 2.67
|
9.75 B
|
$ -13.2 M
|
-3.0
|
986.0
|
$ -0.9
|
 |
 |
Halozyme Therapeutics
HALO
|
$ 70.54
|
8.95 B
|
$ 736 M
|
14.6
|
7.3
|
$ 4.9
|
 |
 |
Axsome Therapeutics
AXSM
|
$ 184.55
|
8.84 B
|
$ -197 M
|
-39.7
|
15.5
|
$ -4.5
|
 |
 |
Arrowhead Pharmaceuticals
ARWR
|
$ 64.91
|
8.68 B
|
$ -610 M
|
-12.6
|
172.0
|
$ -5.0
|
 |
 |
Can-Fite BioPharma Ltd.
CANF
|
$ 3.96
|
8.62 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Avidity Biosciences
RNA
|
$ 72.47
|
8.09 B
|
$ -586 M
|
-18.0
|
399.9
|
$ -4.0
|
 |
 |
Krystal Biotech
KRYS
|
$ 273.95
|
7.83 B
|
$ 145 M
|
45.5
|
22.3
|
$ 6.3
|
 |
 |
Nektar Therapeutics
NKTR
|
$ 35.74
|
6.79 B
|
$ -373 M
|
-0.0
|
72.8
|
$ -791.5
|
 |
 |
Akari Therapeutics, Plc
AKTX
|
$ 0.27
|
6.45 B
|
$ -15.1 M
|
-3.4
|
∙ |
$ -0.1
|
 |
 |
Amarin Corporation plc
AMRN
|
$ 15.43
|
6.29 B
|
$ -48.8 M
|
-98.5
|
26.8
|
$ -0.2
|
 |
 |
Rhythm Pharmaceuticals
RYTM
|
$ 101.29
|
6.18 B
|
$ -189 M
|
-32.7
|
37.4
|
$ -3.1
|
 |
 |
Vaxcyte
PCVX
|
$ 47.56
|
5.8 B
|
$ -581 M
|
-10.0
|
∙ |
$ -4.6
|
 |
 |
Praxis Precision Medicines
PRAX
|
$ 320.12
|
5.73 B
|
$ -198 M
|
-25.0
|
3646.3
|
$ -12.7
|
 |
 |
PTC Therapeutics
PTCT
|
$ 71.55
|
5.5 B
|
$ 906 M
|
8.0
|
3.2
|
$ 9.1
|
 |
 |
Alkermes plc
ALKS
|
$ 31.83
|
5.26 B
|
$ 287 M
|
17.8
|
3.6
|
$ 1.8
|
 |
 |
Longeveron
LGVN
|
$ 0.54
|
5.08 B
|
$ -21.7 M
|
-0.4
|
3221.0
|
$ -1.4
|
 |
 |
Protagonist Therapeutics
PTGX
|
$ 82.4
|
5.07 B
|
$ 120 M
|
-43.2
|
116.7
|
$ -1.9
|
 |
 |
Kymera Therapeutics
KYMR
|
$ 67.54
|
5.07 B
|
$ -316 M
|
-19.7
|
130.2
|
$ -3.5
|
 |
 |
CRISPR Therapeutics AG
CRSP
|
$ 53.21
|
4.49 B
|
$ -601 M
|
-8.7
|
1389.8
|
$ -6.2
|
 |
 |
TG Therapeutics
TGTX
|
$ 30.64
|
4.45 B
|
$ -72.3 M
|
10.4
|
8.8
|
$ 2.9
|
 |
 |
Crinetics Pharmaceuticals
CRNX
|
$ 54.83
|
4.43 B
|
$ -274 M
|
-12.2
|
2338.7
|
$ -4.6
|
 |
 |
Scholar Rock Holding Corporation
SRRK
|
$ 44.12
|
4.4 B
|
$ -216 M
|
-14.0
|
42.7
|
$ -3.2
|
 |
 |
Amicus Therapeutics
FOLD
|
$ 14.32
|
4.36 B
|
$ 46.2 M
|
-130.3
|
7.4
|
$ -0.1
|
 |
 |
Mirum Pharmaceuticals
MIRM
|
$ 91.68
|
4.36 B
|
$ -6.4 M
|
-138.0
|
9.4
|
$ -0.7
|
 |
 |
ACADIA Pharmaceuticals
ACAD
|
$ 26.18
|
4.34 B
|
$ -213 M
|
-17.9
|
8.6
|
$ -1.4
|
 |
 |
Amneal Pharmaceuticals
AMRX
|
$ 13.39
|
4.14 B
|
$ 545 M
|
95.8
|
1.4
|
$ 0.1
|
 |
 |
Immunovant
IMVT
|
$ 26.09
|
3.95 B
|
$ 324 K
|
-8.9
|
∙ |
$ -2.9
|
 |
 |
ADMA Biologics
ADMA
|
$ 17.35
|
3.89 B
|
$ 176 M
|
31.5
|
7.9
|
$ 0.6
|
 |
 |
Viking Therapeutics
VKTX
|
$ 33.53
|
3.66 B
|
$ -201 M
|
-24.0
|
∙ |
$ -1.4
|
 |
 |
Corcept Therapeutics Incorporated
CORT
|
$ 34.84
|
3.6 B
|
$ 80.9 M
|
29.9
|
4.8
|
$ 1.2
|
 |
 |
Ligand Pharmaceuticals Incorporated
LGND
|
$ 193.74
|
3.54 B
|
$ 60.8 M
|
53.0
|
13.6
|
$ 3.6
|
 |
 |
Inhibrx
INBX
|
$ 73.82
|
3.48 B
|
$ -160 M
|
-17.2
|
7671.4
|
$ -4.2
|
 |
 |
Xenon Pharmaceuticals
XENE
|
$ 41.67
|
3.25 B
|
$ -216 M
|
-10.4
|
183.9
|
$ -3.9
|
 |
 |
Arcutis Biotherapeutics
ARQT
|
$ 25.8
|
3.12 B
|
$ -142 M
|
-23.9
|
14.0
|
$ -1.1
|
 |
 |
Spruce Biosciences
SPRB
|
$ 74.01
|
3.05 B
|
$ -51.8 M
|
-2.2
|
416.4
|
$ -34.2
|
 |
 |
Veracyte
VCYT
|
$ 41.6
|
3.02 B
|
$ 48.4 M
|
79.9
|
6.1
|
$ 0.5
|
 |
 |
IDEAYA Biosciences
IDYA
|
$ 35.8
|
2.92 B
|
$ -129 M
|
-37.7
|
12.9
|
$ -1.0
|
 |
 |
Denali Therapeutics
DNLI
|
$ 17.74
|
2.92 B
|
$ -471 M
|
-6.3
|
8.9
|
$ -2.9
|
 |
 |
Kiniksa Pharmaceuticals, Ltd.
KNSA
|
$ 40.51
|
2.89 B
|
$ 24.2 M
|
328.4
|
5.5
|
$ 0.1
|
 |
 |
Catalyst Pharmaceuticals
CPRX
|
$ 23.26
|
2.76 B
|
$ 152 M
|
13.4
|
4.8
|
$ 1.7
|
 |
 |
Supernus Pharmaceuticals
SUPN
|
$ 49.5
|
2.73 B
|
$ 4.48 M
|
555.6
|
4.0
|
$ 0.1
|
 |
 |
Tarsus Pharmaceuticals
TARS
|
$ 70.76
|
2.66 B
|
$ -87.3 M
|
-35.0
|
7.7
|
$ -2.0
|
 |
 |
Viridian Therapeutics
VRDN
|
$ 32.69
|
2.65 B
|
$ -251 M
|
-8.2
|
38.0
|
$ -4.0
|
 |
 |
Adaptive Biotechnologies Corporation
ADPT
|
$ 17.71
|
2.61 B
|
$ -60.1 M
|
-33.1
|
10.2
|
$ -0.5
|
 |
 |
Liquidia Corporation
LQDA
|
$ 39.61
|
2.57 B
|
$ -99.1 M
|
-27.5
|
34.8
|
$ -1.4
|
 |
 |
Beam Therapeutics
BEAM
|
$ 31.25
|
2.57 B
|
$ -451 M
|
-6.9
|
64.4
|
$ -4.5
|
 |
 |
Apellis Pharmaceuticals
APLS
|
$ 20.05
|
2.48 B
|
$ -471 M
|
-10.9
|
3.3
|
$ -1.8
|
 |
 |
RAPT Therapeutics
RAPT
|
$ 57.51
|
2.34 B
|
$ -77 M
|
-6.8
|
355.9
|
$ -5.2
|
 |
 |
Aurinia Pharmaceuticals
AUPH
|
$ 14.78
|
2.11 B
|
$ 60.9 M
|
29.1
|
7.9
|
$ 0.5
|
 |
 |
Ultragenyx Pharmaceutical
RARE
|
$ 22.6
|
2.05 B
|
$ -664 M
|
-3.8
|
5.8
|
$ -6.0
|
 |
 |
Harmony Biosciences Holdings
HRMY
|
$ 35.92
|
2.04 B
|
$ 250 M
|
11.4
|
2.5
|
$ 3.2
|
 |
 |
Dynavax Technologies Corporation
DVAX
|
$ 15.63
|
2.03 B
|
$ -3.96 M
|
-62.5
|
6.0
|
$ -0.2
|
 |
 |
DBV Technologies S.A.
DBVT
|
$ 20.86
|
2.02 B
|
$ -83 M
|
-16.9
|
452.8
|
$ -1.2
|
 |
 |
Sarepta Therapeutics
SRPT
|
$ 20.81
|
1.98 B
|
$ -254 M
|
-5.2
|
0.9
|
$ -4.0
|
 |
 |
Seres Therapeutics
MCRB
|
$ 15.17
|
1.94 B
|
$ -99.2 M
|
1.1
|
16.1
|
$ 14.1
|
 |
 |
Arcus Biosciences
RCUS
|
$ 21.53
|
1.94 B
|
$ -281 M
|
-6.8
|
7.1
|
$ -3.2
|
 |
 |
Sol-Gel Technologies Ltd.
SLGL
|
$ 68.11
|
1.9 B
|
$ -28.2 M
|
52.7
|
189.9
|
$ 1.3
|
 |
 |
Wave Life Sciences Ltd.
WVE
|
$ 13.64
|
1.89 B
|
$ -145 M
|
-9.8
|
37.7
|
$ -1.4
|
 |
 |
Ardelyx
ARDX
|
$ 7.7
|
1.81 B
|
$ -107 M
|
-15.7
|
4.6
|
$ -0.4
|
 |
 |
Ocular Therapeutix
OCUL
|
$ 11.39
|
1.8 B
|
$ -136 M
|
-8.2
|
33.0
|
$ -1.4
|
 |
 |
Vericel Corporation
VCEL
|
$ 36.25
|
1.77 B
|
$ -4.45 M
|
-233.8
|
7.6
|
$ -0.2
|
 |
 |
Syndax Pharmaceuticals
SNDX
|
$ 20.19
|
1.73 B
|
$ -130 M
|
-5.9
|
15.1
|
$ -3.5
|
 |
 |
ANI Pharmaceuticals
ANIP
|
$ 86.04
|
1.66 B
|
$ 140 M
|
85.7
|
2.1
|
$ 1.0
|
 |
 |
Burford Capital Limited
BUR
|
$ 9.65
|
1.56 B
|
∙ |
∙ |
∙ |
∙ |
 |
 |
Agios Pharmaceuticals
AGIO
|
$ 26.98
|
1.53 B
|
$ -381 M
|
2.4
|
39.8
|
$ 11.5
|
 |
 |
Certara
CERT
|
$ 9.52
|
1.53 B
|
$ 65.2 M
|
475.5
|
3.7
|
$ 0.0
|
 |
 |
MannKind Corporation
MNKD
|
$ 5.46
|
1.5 B
|
$ 67.5 M
|
52.1
|
4.7
|
$ 0.1
|
 |
 |
Collegium Pharmaceutical
COLL
|
$ 46.5
|
1.49 B
|
$ 158 M
|
26.1
|
2.0
|
$ 1.8
|
 |
 |
Cidara Therapeutics
CDTX
|
$ 221.38
|
1.41 B
|
$ -15.9 M
|
-25.0
|
90.2
|
$ -8.9
|
 |
 |
Kodiak Sciences
KOD
|
$ 26.4
|
1.38 B
|
$ -244 M
|
-6.6
|
∙ |
$ -4.1
|
 |
 |
BioCryst Pharmaceuticals
BCRX
|
$ 6.64
|
1.37 B
|
$ -37 M
|
-133.2
|
2.4
|
$ -0.0
|
 |
 |
AnaptysBio
ANAB
|
$ 46.37
|
1.32 B
|
$ -143 M
|
-14.2
|
8.3
|
$ -3.2
|
 |
 |
Novavax
NVAX
|
$ 8.62
|
1.31 B
|
$ -17.9 M
|
4.3
|
1.2
|
$ 1.9
|
 |
 |
Intellia Therapeutics
NTLA
|
$ 12.94
|
1.28 B
|
$ -477 M
|
-2.9
|
23.0
|
$ -4.3
|
 |
 |
Amphastar Pharmaceuticals
AMPH
|
$ 26.11
|
1.26 B
|
$ 211 M
|
10.9
|
1.7
|
$ 2.4
|
 |
 |
Nurix Therapeutics
NRIX
|
$ 18.66
|
1.25 B
|
$ -190 M
|
-6.6
|
15.5
|
$ -2.9
|
 |
 |
Stoke Therapeutics
STOK
|
$ 28.24
|
1.24 B
|
$ 33.6 M
|
66.7
|
6.7
|
$ 0.4
|
 |
 |
Zymeworks
ZYME
|
$ 24.01
|
1.24 B
|
$ -268 M
|
-5.1
|
138.7
|
$ -4.6
|
 |
 |
AbCellera Biologics
ABCL
|
$ 4.17
|
1.23 B
|
$ -229 M
|
-6.5
|
33.0
|
$ -0.6
|
 |
 |
Innoviva
INVA
|
$ 19.56
|
1.23 B
|
$ 194 M
|
12.2
|
3.2
|
$ 1.6
|
 |
 |
Olema Pharmaceuticals
OLMA
|
$ 26.7
|
1.21 B
|
$ -121 M
|
-13.8
|
∙ |
$ -2.0
|
 |
 |
Taysha Gene Therapies
TSHA
|
$ 4.59
|
1.15 B
|
$ -107 M
|
-12.7
|
158.7
|
$ -0.4
|
 |
 |
Xeris Pharmaceuticals
XERS
|
$ 7.64
|
1.12 B
|
$ 3.68 M
|
-26.9
|
4.2
|
$ -0.3
|
 |
 |
Precigen
PGEN
|
$ 4.55
|
1.11 B
|
$ 14.9 M
|
-3.1
|
46.4
|
$ -1.4
|
 |
 |
uniQure N.V.
QURE
|
$ 22.47
|
1.09 B
|
$ -211 M
|
-6.0
|
86.7
|
$ -3.8
|
 |
 |
Relay Therapeutics
RLAY
|
$ 7.49
|
1.07 B
|
$ -356 M
|
-3.8
|
24.1
|
$ -1.9
|
 |
 |
Trevi Therapeutics
TRVI
|
$ 10.22
|
1.01 B
|
$ -39.2 M
|
-26.9
|
∙ |
$ -0.4
|
 |
 |
Theravance Biopharma
TBPH
|
$ 20.28
|
991 M
|
$ -131 M
|
35.7
|
12.6
|
$ 0.6
|
 |
 |
Savara
SVRA
|
$ 5.89
|
973 M
|
$ -116 M
|
-11.4
|
1209.4
|
$ -0.5
|
 |
 |
Corvus Pharmaceuticals
CRVS
|
$ 19.27
|
925 M
|
$ -37.9 M
|
-13.2
|
∙ |
$ -0.6
|
 |
 |
Catalyst Biosciences
CBIO
|
$ 14.02
|
923 M
|
$ 16.5 M
|
111.7
|
8.4
|
$ 0.1
|
 |
 |
BioLineRx Ltd.
BLRX
|
$ 2.97
|
908 M
|
$ -24.3 M
|
-21.9
|
∙ |
$ -0.1
|
 |
 |
Phathom Pharmaceuticals
PHAT
|
$ 14.34
|
906 M
|
$ -296 M
|
-2.7
|
9.7
|
$ -5.2
|
 |
 |
Sana Biotechnology
SANA
|
$ 4.64
|
903 M
|
$ -237 M
|
-4.5
|
∙ |
$ -1.0
|
 |
 |
Sutro Biopharma
STRO
|
$ 14.8
|
890 M
|
$ -179 M
|
-6.0
|
8.4
|
$ -2.3
|
 |
 |
Arvinas
ARVN
|
$ 12.21
|
878 M
|
$ -101 M
|
-14.2
|
2.5
|
$ -0.9
|
 |
 |
Annexon
ANNX
|
$ 6.15
|
845 M
|
$ -180 M
|
-5.1
|
∙ |
$ -1.2
|
 |
 |
ORIC Pharmaceuticals
ORIC
|
$ 11.95
|
833 M
|
$ -112 M
|
-7.1
|
∙ |
$ -1.7
|
 |
 |
Xencor
XNCR
|
$ 12.73
|
828 M
|
$ -169 M
|
-6.8
|
7.2
|
$ -1.9
|
 |
 |
Biohaven Pharmaceutical Holding Company Ltd.
BHVN
|
$ 12.73
|
823 M
|
$ -651 M
|
-0.9
|
1.4
|
$ -15.0
|
 |
 |
Vir Biotechnology
VIR
|
$ 6.11
|
820 M
|
$ -669 M
|
-1.3
|
117.6
|
$ -4.6
|
 |
 |
KalVista Pharmaceuticals
KALV
|
$ 15.15
|
752 M
|
$ -159 M
|
-3.9
|
16.6
|
$ -3.8
|
 |
 |
Geron Corporation
GERN
|
$ 1.31
|
748 M
|
$ -152 M
|
-10.9
|
4.6
|
$ -0.1
|
 |
 |
Kura Oncology
KURA
|
$ 8.65
|
745 M
|
$ -118 M
|
-2.9
|
14.5
|
$ -2.9
|
 |
 |
Passage Bio
PASG
|
$ 12.23
|
739 M
|
$ -54.7 M
|
-1.1
|
∙ |
$ -11.8
|
 |
 |
Ironwood Pharmaceuticals
IRWD
|
$ 4.52
|
719 M
|
$ 113 M
|
23.7
|
2.1
|
$ 0.2
|
 |
 |
Omeros Corporation
OMER
|
$ 12.27
|
714 M
|
$ -128 M
|
-5.9
|
7.7
|
$ -2.0
|
 |
 |
Arbutus Biopharma Corporation
ABUS
|
$ 4.24
|
704 M
|
$ -78.1 M
|
-15.6
|
46.9
|
$ -0.3
|
 |
 |
Keros Therapeutics
KROS
|
$ 18.57
|
695 M
|
$ 38 M
|
14.4
|
2.9
|
$ 1.3
|
 |
 |
Galecto
GLTO
|
$ 24.68
|
656 M
|
$ -13 M
|
-2.4
|
∙ |
$ -10.3
|
 |
 |
X4 Pharmaceuticals
XFOR
|
$ 3.67
|
653 M
|
$ -9.29 M
|
-0.4
|
137.9
|
$ -9.6
|
 |
 |
Capricor Therapeutics
CAPR
|
$ 23.95
|
641 M
|
$ -90.2 M
|
-12.0
|
37.6
|
$ -2.0
|
 |
 |
Rigel Pharmaceuticals
RIGL
|
$ 36.26
|
637 M
|
$ 119 M
|
6.0
|
2.4
|
$ 6.2
|
 |
 |
Cullinan Management
CGEM
|
$ 10.82
|
633 M
|
$ -190 M
|
-3.3
|
33.1
|
$ -3.2
|
 |
 |
REGENXBIO
RGNX
|
$ 13.92
|
609 M
|
$ -246 M
|
-2.8
|
6.1
|
$ -4.8
|
 |
 |
Replimune Group
REPL
|
$ 7.1
|
572 M
|
$ -296 M
|
-2.1
|
∙ |
$ -3.3
|
 |
 |
Esperion Therapeutics
ESPR
|
$ 2.94
|
550 M
|
$ -164 M
|
-5.2
|
2.0
|
$ -0.6
|
 |
 |
UroGen Pharma Ltd.
URGN
|
$ 19.05
|
549 M
|
$ -112 M
|
-6.1
|
5.5
|
$ -3.1
|
 |
 |
Aligos Therapeutics
ALGS
|
$ 8.06
|
518 M
|
$ -85.3 M
|
-3.2
|
156.2
|
$ -2.5
|
 |
 |
Prothena Corporation plc
PRTA
|
$ 9.54
|
513 M
|
$ -256 M
|
-1.8
|
47.3
|
$ -5.2
|
 |
 |
Maravai LifeSciences Holdings
MRVI
|
$ 3.8
|
501 M
|
$ -264 M
|
-3.3
|
2.3
|
$ -1.2
|
 |
 |
Benitec Biopharma
BNTC
|
$ 11.8
|
486 M
|
$ -34.3 M
|
-12.0
|
3698.2
|
$ -1.0
|
 |
 |
Ocugen
OCGN
|
$ 1.66
|
484 M
|
$ -74.6 M
|
-6.8
|
85.8
|
$ -0.2
|
 |
 |
Immunome
IMNM
|
$ 23.83
|
473 M
|
$ -154 M
|
-8.9
|
43.1
|
$ -2.5
|
 |
 |
SIGA Technologies
SIGA
|
$ 6.59
|
470 M
|
$ 50.6 M
|
15.7
|
4.7
|
$ 0.4
|
 |
 |
CytomX Therapeutics
CTMX
|
$ 5.45
|
460 M
|
$ -53.6 M
|
77.0
|
5.5
|
$ 0.1
|
 |
 |
Cerus Corporation
CERS
|
$ 2.49
|
460 M
|
$ -31.5 M
|
-21.7
|
9.4
|
$ -0.1
|
 |
 |
Kezar Life Sciences
KZR
|
$ 6.24
|
453 M
|
$ -64.9 M
|
-0.7
|
64.3
|
$ -8.4
|
 |
 |
XTL Biopharmaceuticals Ltd.
XTLB
|
$ 0.96
|
442 M
|
$ -520 K
|
∙ |
∙ |
∙ |
 |
 |
Vanda Pharmaceuticals
VNDA
|
$ 7.52
|
437 M
|
$ -95.2 M
|
-6.6
|
2.2
|
$ -1.1
|
 |
 |
Anavex Life Sciences Corp.
AVXL
|
$ 5.04
|
430 M
|
$ -51.1 M
|
-8.8
|
∙ |
$ -0.6
|
 |
 |
RedHill Biopharma Ltd.
RDHL
|
$ 1.38
|
428 M
|
$ -59.3 M
|
7.2
|
9.2
|
$ 0.2
|
 |
 |
Lexicon Pharmaceuticals
LXRX
|
$ 1.33
|
426 M
|
$ -124 M
|
-4.9
|
9.5
|
$ -0.3
|
 |
 |
MeiraGTx Holdings plc
MGTX
|
$ 7.41
|
419 M
|
$ -160 M
|
-3.4
|
27.4
|
$ -2.2
|
 |
 |
Gossamer Bio
GOSS
|
$ 2.59
|
395 M
|
$ -59.8 M
|
-3.7
|
8.7
|
$ -0.7
|
 |
 |
Eton Pharmaceuticals
ETON
|
$ 15.26
|
391 M
|
$ -2.42 M
|
-72.1
|
5.6
|
$ -0.2
|
 |
 |
Bicycle Therapeutics plc
BCYC
|
$ 6.65
|
387 M
|
$ -260 M
|
-1.8
|
15.2
|
$ -3.5
|
 |
 |
Autolus Therapeutics plc
AUTL
|
$ 1.45
|
370 M
|
$ -258 M
|
-1.3
|
5.8
|
$ -1.0
|
 |
 |
NextCure
NXTC
|
$ 13.1
|
366 M
|
$ -76.6 M
|
-0.6
|
5.2
|
$ -19.8
|
 |
 |
CEL-SCI Corporation
CVM
|
$ 5.7
|
364 M
|
$ -24.4 M
|
-4.1
|
1022.7
|
$ -1.3
|
 |
 |
Generation Bio Co.
GBIO
|
$ 5.6
|
361 M
|
$ -59.2 M
|
-0.9
|
19.4
|
$ -6.4
|
 |
 |
CorMedix
CRMD
|
$ 6.82
|
347 M
|
$ 47.5 M
|
3.4
|
1.8
|
$ 2.0
|
 |
 |
Rocket Pharmaceuticals
RCKT
|
$ 3.61
|
342 M
|
$ -251 M
|
-1.6
|
∙ |
$ -2.3
|
 |
 |
Aclaris Therapeutics
ACRS
|
$ 4.26
|
329 M
|
$ -63.6 M
|
-5.5
|
18.6
|
$ -0.5
|
 |
 |
Verrica Pharmaceuticals
VRCA
|
$ 7.21
|
327 M
|
$ -25.5 M
|
-1.4
|
11.5
|
$ -5.0
|
 |
 |
Puma Biotechnology
PBYI
|
$ 6.53
|
318 M
|
$ 45.4 M
|
8.3
|
1.3
|
$ 0.8
|
 |
 |
Foghorn Therapeutics
FHTX
|
$ 5.71
|
313 M
|
$ -83 M
|
-5.3
|
11.2
|
$ -1.1
|
 |
 |
Aquestive Therapeutics
AQST
|
$ 3.51
|
304 M
|
$ -30.5 M
|
-7.5
|
5.1
|
$ -0.4
|
 |
 |
Altimmune
ALT
|
$ 4.21
|
299 M
|
$ -95.3 M
|
-4.0
|
15052.7
|
$ -1.1
|
 |
 |
Tonix Pharmaceuticals Holding Corp.
TNXP
|
$ 17.22
|
293 M
|
$ -91.1 M
|
-0.5
|
27.7
|
$ -33.0
|
 |
 |
Atea Pharmaceuticals
AVIR
|
$ 3.44
|
290 M
|
$ -166 M
|
-2.0
|
1.8
|
$ -1.7
|
 |
 |
Lineage Cell Therapeutics
LCTX
|
$ 1.67
|
288 M
|
$ -33.3 M
|
-5.7
|
25.0
|
$ -0.3
|
 |
 |
Aldeyra Therapeutics
ALDX
|
$ 4.81
|
286 M
|
$ -51 M
|
-6.5
|
∙ |
$ -0.7
|
 |
 |
Greenwich LifeSciences
GLSI
|
$ 21.39
|
278 M
|
$ -14.2 M
|
-23.7
|
∙ |
$ -1.0
|
 |
 |
Monopar Therapeutics
MNPR
|
$ 69.46
|
263 M
|
$ -12.1 M
|
-44.3
|
∙ |
$ -1.6
|
 |
 |
Kamada Ltd.
KMDA
|
$ 7.82
|
260 M
|
$ 6.96 M
|
62.8
|
4.5
|
$ 0.1
|
 |
 |
Akebia Therapeutics
AKBA
|
$ 1.34
|
251 M
|
$ -3.97 M
|
-6.8
|
1.2
|
$ -0.2
|
 |
 |
Allogene Therapeutics
ALLO
|
$ 1.59
|
250 M
|
$ -295 M
|
-1.6
|
2664.6
|
$ -1.0
|
 |
 |
Sensei Biotherapeutics
SNSE
|
$ 9.93
|
249 M
|
$ -31.2 M
|
-0.8
|
∙ |
$ -13.6
|
 |
 |
DiaMedica Therapeutics
DMAC
|
$ 7.39
|
241 M
|
$ -22.5 M
|
-11.2
|
493.7
|
$ -0.7
|
 |
 |
Heron Therapeutics
HRTX
|
$ 1.47
|
224 M
|
$ -72.5 M
|
-11.5
|
1.5
|
$ -0.1
|
 |
 |
Rezolute
RZLT
|
$ 2.84
|
216 M
|
$ -67 M
|
-3.1
|
∙ |
$ -0.9
|
 |
 |
Armata Pharmaceuticals
ARMP
|
$ 5.93
|
214 M
|
$ -31.2 M
|
-4.2
|
7447.9
|
$ -1.5
|
 |
 |
Compugen Ltd.
CGEN
|
$ 2.24
|
201 M
|
∙ |
∙ |
26.4
|
∙ |
 |
 |
Forte Biosciences
FBRX
|
$ 31.1
|
199 M
|
$ -30.3 M
|
-4.2
|
11.8
|
$ -7.9
|
 |
 |
Fennec Pharmaceuticals
FENC
|
$ 7.42
|
197 M
|
$ -20.6 M
|
-20.0
|
5.3
|
$ -0.4
|
 |
 |
Arcturus Therapeutics Holdings
ARCT
|
$ 7.16
|
193 M
|
$ -56.6 M
|
-4.2
|
1.4
|
$ -1.7
|
 |
 |
Zentalis Pharmaceuticals
ZNTL
|
$ 2.91
|
190 M
|
$ -166 M
|
-1.5
|
5.0
|
$ -2.0
|
 |
 |
Galectin Therapeutics
GALT
|
$ 2.95
|
184 M
|
$ -36 M
|
-5.2
|
-485.7
|
$ -0.6
|
 |
 |
Shattuck Labs
STTK
|
$ 4.28
|
182 M
|
$ -76.3 M
|
-4.7
|
29.4
|
$ -1.0
|
 |
 |
Alector
ALEC
|
$ 1.84
|
178 M
|
$ -178 M
|
-1.2
|
5.9
|
$ -1.5
|
 |
 |
Editas Medicine
EDIT
|
$ 2.04
|
168 M
|
$ -242 M
|
-0.8
|
10.6
|
$ -2.6
|
 |
 |
Voyager Therapeutics
VYGR
|
$ 3.73
|
160 M
|
$ 95.1 M
|
-2.2
|
3.3
|
$ -1.7
|
 |
 |
C4 Therapeutics
CCCC
|
$ 2.16
|
150 M
|
$ -119 M
|
-1.5
|
3.9
|
$ -1.5
|
 |
 |
BiomX
PHGE
|
$ 2.91
|
149 M
|
$ -26.2 M
|
5.4
|
∙ |
$ 0.5
|
 |
 |
Verastem
VSTM
|
$ 6.72
|
148 M
|
$ -109 M
|
-2.0
|
5.7
|
$ -3.3
|
 |
 |
Coherus BioSciences
CHRS
|
$ 1.54
|
145 M
|
$ -181 M
|
1.0
|
4.2
|
$ 1.7
|
 |
 |
Larimar Therapeutics
LRMR
|
$ 3.2
|
140 M
|
$ -63.6 M
|
-1.8
|
∙ |
$ -1.7
|
 |
 |
Oramed Pharmaceuticals
ORMP
|
$ 3.48
|
140 M
|
$ -20.7 M
|
4.5
|
36.9
|
$ 0.8
|
 |
 |
Anika Therapeutics
ANIK
|
$ 9.46
|
139 M
|
$ -6.4 M
|
-3.3
|
1.2
|
$ -2.8
|
 |
 |
Protalix BioTherapeutics
PLX
|
$ 2.03
|
137 M
|
$ -12.8 M
|
-204.0
|
2.2
|
$ -0.0
|
 |
 |
Cardiff Oncology
CRDF
|
$ 2.84
|
135 M
|
$ -53.4 M
|
-3.5
|
266.5
|
$ -0.8
|
 |
 |
Black Diamond Therapeutics
BDTX
|
$ 2.4
|
132 M
|
$ -91.7 M
|
-2.6
|
∙ |
$ -1.0
|
 |
 |
vTv Therapeutics
VTVT
|
$ 33.5
|
132 M
|
$ -23.5 M
|
∙ |
27.9
|
∙ |
 |
 |
CASI Pharmaceuticals
CASI
|
$ 0.95
|
129 M
|
$ -27.1 M
|
-0.6
|
3.6
|
$ -1.7
|
 |
 |
Assembly Biosciences
ASMB
|
$ 28.22
|
129 M
|
$ -63.1 M
|
-6.2
|
3.7
|
$ -4.7
|
 |
 |
Fate Therapeutics
FATE
|
$ 1.13
|
128 M
|
$ -186 M
|
-0.9
|
16.2
|
$ -1.3
|
 |
 |
Spero Therapeutics
SPRO
|
$ 2.36
|
124 M
|
$ -80.8 M
|
-3.3
|
3.3
|
$ -0.7
|
 |
 |
Codexis
CDXS
|
$ 1.63
|
120 M
|
$ -63.9 M
|
-1.8
|
2.8
|
$ -0.9
|
 |
 |
Seer
SEER
|
$ 1.86
|
119 M
|
$ -96.5 M
|
-1.4
|
8.4
|
$ -1.4
|
 |
 |
Cellectis S.A.
CLLS
|
$ 4.14
|
116 M
|
$ -106 M
|
-1.7
|
7.6
|
$ -2.4
|
 |
 |
Prelude Therapeutics Incorporated
PRLD
|
$ 1.91
|
115 M
|
$ -126 M
|
-1.2
|
11.5
|
$ -1.5
|
 |
 |
SELLAS Life Sciences Group
SLS
|
$ 4.14
|
115 M
|
$ -39.5 M
|
-13.3
|
9.2
|
$ -0.3
|
 |
 |
Lyra Therapeutics
LYRA
|
$ 2.3
|
115 M
|
$ -72.2 M
|
-0.1
|
169.1
|
$ -18.1
|
 |
 |
Protara Therapeutics
TARA
|
$ 5.55
|
114 M
|
$ -43.3 M
|
-3.5
|
35.0
|
$ -1.4
|
 |
 |
Abeona Therapeutics
ABEO
|
$ 5.31
|
114 M
|
$ -79.6 M
|
4.8
|
18.0
|
$ 1.1
|
 |
 |
MacroGenics
MGNX
|
$ 1.79
|
111 M
|
$ -145 M
|
-34.4
|
0.5
|
$ -0.0
|
 |
 |
Achieve Life Sciences
ACHV
|
$ 5.58
|
111 M
|
$ 448 K
|
-4.2
|
∙ |
$ -1.4
|
 |
 |
Repare Therapeutics
RPTX
|
$ 2.58
|
109 M
|
$ 22 M
|
-1.4
|
∙ |
$ -1.8
|
 |
 |
Ovid Therapeutics
OVID
|
$ 1.54
|
109 M
|
$ -43 M
|
-3.8
|
16.5
|
$ -0.4
|
 |
 |
Adagene
ADAG
|
$ 1.9
|
107 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
ADC Therapeutics SA
ADCT
|
$ 3.54
|
105 M
|
$ -239 M
|
-1.3
|
6.2
|
$ -2.8
|
 |
 |
Nkarta
NKTX
|
$ 2.04
|
100 M
|
$ -116 M
|
-1.4
|
852.4
|
$ -1.4
|
 |
 |
Champions Oncology
CSBR
|
$ 7.25
|
99 M
|
$ 1.27 M
|
-240.3
|
1.8
|
$ -0.0
|
 |
 |
Cassava Sciences
SAVA
|
$ 2.0
|
92.7 M
|
$ -112 M
|
-0.9
|
2.3
|
$ -2.2
|
 |
 |
MediciNova
MNOV
|
$ 1.68
|
82.4 M
|
$ -13.2 M
|
-6.4
|
60.6
|
$ -0.2
|
 |
 |
XBiotech
XBIT
|
$ 2.58
|
78.5 M
|
$ -34.4 M
|
-3.3
|
9.5
|
$ -0.8
|
 |
 |
Pliant Therapeutics
PLRX
|
$ 1.26
|
76.3 M
|
$ -193 M
|
-0.4
|
9.7
|
$ -3.0
|
 |
 |
Entera Bio Ltd.
ENTX
|
$ 1.65
|
75.7 M
|
$ -8.21 M
|
3.2
|
316.1
|
$ 0.5
|
 |
 |
Atossa Therapeutics
ATOS
|
$ 0.6
|
75.6 M
|
$ -29.7 M
|
-2.5
|
685.6
|
$ -0.2
|
 |
 |
Fortress Biotech
FBIO
|
$ 3.46
|
71.9 M
|
$ -87.3 M
|
-6.1
|
1.2
|
$ -0.6
|
 |
 |
Tiziana Life Sciences PLC
TLSA
|
$ 1.63
|
71.5 M
|
∙ |
∙ |
∙ |
∙ |
 |
 |
ALX Oncology Holdings
ALXO
|
$ 1.31
|
68.3 M
|
$ -113 M
|
-0.6
|
16.9
|
$ -2.1
|
 |